Cutaneous Clear Cell Hidradenoma
An adult woman with a history of melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma presented for her yearly skin evaluation. Examination showed an approximately 1-cm, shiny, pink, nodular-lobulated lesion with nonarborizing telangiectasias involving the upper chest near the neck (Figure 1). Because the clinical morphology was concerning for a BCC, shave biopsy followed by electrodessication and curettage was performed. Histologic examination revealed a well-demarcated mid to deep dermal neoplasm composed of solid nodules and small nests of epithelial cells without cytologic atypia or mitoses but exhibiting biphasic features consisting of polygonal cells with vesicular nuclei and eosinophilic cytoplasm as well as cells with clear cytoplasm, on a background of rich intratumoral vasculature and hyalinized stroma, characteristic of clear cell hidradenoma (Figure 2).
