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Mashup Score: 0
Systemic antibiotic exposure in the first year of life is associated with higher atopic dermatitis (AD) risk in a dose-response fashion, according to a study published online April 24 in the Journal of …
Source: medicalxpress.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 0Sex and gender-based analysis and diversity metric reporting in acute care trials published in high-impact journals: a systematic review - 1 hour(s) ago
Objective To characterise sex and gender-based analysis (SGBA) and diversity metric reporting, representation of female/women participants in acute care trials and temporal changes in reporting before and after publication of the 2016 Sex and Gender Equity in Research guideline. Design Systematic review. Data sources We searched MEDLINE for trials published in five leading medical journals in 2014, 2018 and 2020. Study selection Trials that enrolled acutely ill adults, compared two or more interventions and reported at least one clinical outcome. Data abstraction and synthesis 4 reviewers screened citations and 22 reviewers abstracted data, in duplicate. We compared reporting differences between intensive care unit (ICU) and cardiology trials. Results We included 88 trials (75 (85.2%) ICU and 13 (14.8%) cardiology) (n=111 428; 38 140 (34.2%) females/women). Of 23 (26.1%) trials that reported an SGBA, most used a forest plot (22 (95.7%)), were prespecified (21 (91.3%)) and reported a se
Source: bmjopen.bmj.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Simpson’s paradox | Definition, Example, and Explanation - 1 hour(s) ago
Simpson’s paradox, in statistics, an effect that occurs when the marginal association between two categorical variables is qualitatively different from the partial association between the same two variables after controlling for one or more other variables. Simpson’s paradox is important for three
Source: www.britannica.comCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 5Discontinuation of psychotropic medication: a synthesis of evidence across medication classes - 1 hour(s) ago
Molecular Psychiatry – Discontinuation of psychotropic medication: a synthesis of evidence across medication classes
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0One machine learning question every day - bnomial - 1 hour(s) ago
Daily multi-choice machine learning, data science, and artificial intelligence questions.
Source: today.bnomial.comCategories: General Medicine News, Cardiologists1Tweet
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Mashup Score: 0
A leading NHS boss says firms are deliberately targeting areas where nurses are in short supply.
Source: www.bbc.co.ukCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Labeling Energy Drinks: Tackling a Monster of a Problem - 2 hour(s) ago
Energy drinks first rose to popularity in the 1980s. Red Bull energy drinks were the first of its kind, opening the door to a new consumer and regulatory landsc
Source: papers.ssrn.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 2Researchers identify what drives PARP inhibitor resistance in advanced breast cancer - 2 hour(s) ago
Researchers at The Institute of Cancer Research, London, have increased our understanding of how a cancer drug called a PARP inhibitor stops working in women with breast cancer that has spread. This research …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Novel autoantibodies help diagnose anti-SSA antibody negative Sjögren disease and predict abnormal labial salivary gland pathology - 2 hour(s) ago
Objectives Sjögren disease (SjD) diagnosis often requires either positive anti-SSA antibodies or a labial salivary gland biopsy with a positive focus score (FS). One-third of patients with SjD lack anti-SSA antibodies (SSA−), requiring a positive FS for diagnosis. Our objective was to identify novel autoantibodies to diagnose ‘seronegative’ SjD. Methods IgG binding to a high-density whole human peptidome array was quantified using sera from SSA− SjD cases and matched non-autoimmune controls. We identified the highest bound peptides using empirical Bayesian statistical filters, which we confirmed in an independent cohort comprising SSA− SjD (n=76), sicca-controls without autoimmunity (n=75) and autoimmune-feature controls (SjD features but not meeting SjD criteria; n=41). In this external validation, we used non-parametric methods for binding abundance and controlled false discovery rate in group comparisons. For predictive modelling, we used logistic regression, model selection methods
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 1
Getting evidence-based care may be like pulling teeth, researchers suggest.
Source: arstechnica.comCategories: General Medicine News, Hem/OncsTweet
Systemic #antibiotics in first year of life tied to higher #atopic #dermatitis risk https://t.co/8fQsDnMZvD