“Unheard of in structural biology”: New enzyme models reveal disease insights
Structural models of PLD3 and PLD4, enzymes that degrade nucleic acids in the c ytoplasm. The enzymes’ active (or binding) sites are indicated with black arrows. Credit: Scripps Research Scripps Research scientists create atomic-level structural models of enzymes associated with autoimmune and inflammatory diseases, including lupus and Alzheimer’ s. LA JOLLA, CA — When nucleic acids like DNA or RNA build up in a cell’s cytoplasm, it sets off an alarm call for the immune system. Enzymes usually clear