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Mashup Score: 1X chromosome enhances NK cell responses - 11 month(s) ago
Incomplete X-chromosome inactivation (XCI) can cause differences between sexes. Cheng et al. identified that the histone demethylase UTX, encoded by a…
Source: www.sciencedirect.comCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 8Please wait whilst we redirect you - 1 year(s) ago
About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyWe use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies.Copyright © 2023 Elsevier B.V. or its licensors or contributors. ScienceDirect® is a registered trademark of Elsevier B.V.ScienceDirect® is a registered trademark…
Source: www.sciencedirect.comCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 1New tRNA-targeting transposons that hijack phage and vesicles - 1 year(s) ago
Genomic islands are hotspots for horizontal gene transfer (HGT) in bacteria, but, for Prochlorococcus, an abundant marine cyanobacterium, how these islands form has puzzled scientists. With the discovery of tycheposons, a new family of transposons, Hackl et al. provide evidence for elegant new mechanisms of gene rearrangement and transfer among Prochlorococcus and bacteria more broadly.
Source: Trends in GeneticsCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 3Prepping for climate change by introgressive hybridization - 1 year(s) ago
Species and populations may adapt to climate change by microevolutionary processes. However, standing genetic variation can be insufficient for this to occur. An interesting new study of a system of rainbowfish species shows that intraspecific hybridization enriches gene pools with adaptive variation that may allow persistence in a changing climate.
Source: Trends in GeneticsCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 3Why are whales big? Genes behind ocean giants - 1 year(s) ago
Gigantism is prevalent in animals, but it has never reached more extreme levels than in aquatic mammals such as whales, dolphins, and porpoises. A new study by Silva et al. has uncovered five genes underlying this gigantism, a phenotype with important connections to aging and cancer suppression in long-lived animals.
Source: Trends in GeneticsCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 2
The burden of human diseases is dominated by complex, polygenic disease rather than by monogenic disorders associated with single, highly penetrant, genetic mutations. Since the mid-2000s, GWAS have been the preferred tool for identifying associations between genetic variants and complex traits [1]. While the association between genomic variation and phenotype has long been understood, GWAS have…
Source: Trends in GeneticsCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 1
The genomes of cytoplasmic organelles (mitochondria and plastids) are maternally inherited in most eukaryotes, thus excluding organellar genomes from the benefits of sexual reproduction and recombination. The mechanisms underlying maternal inheritance are largely unknown. Here we demonstrate that two independently acting mechanisms ensure maternal inheritance of the plastid (chloroplast) genome….
Source: www.nature.comCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0Maternal plastid inheritance: two abating factors identified - 1 year(s) ago
Organelle DNAs (orgDNAs) in mitochondria and plastids are generally inherited from the maternal parent; however, it is unclear how their inheritance mode is controlled, particularly in the plastids of seed plants. Chung et al. identify two factors that affect maternal inheritance in tobacco plastids: cold temperature and DNA amount in pollen.
Source: Trends in GeneticsCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 1Repetitive elements in aging and neurodegeneration - 1 year(s) ago
REs comprise approximately half of the genome, with classes of REs including TEs (see Glossary), satellite DNA, rDNA, and segmental duplications [1]. Until recently, REs were mostly ignored due to: (i) their repetitive nature, which complicates sequencing; and (ii) the widespread perception that REs were ‘junk’ DNA [2]. Advances in sequencing technology and computational analysis of repetitive…
Source: Trends in GeneticsCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0Start of life controlled by poly(A) tail-mediated remodeling - 1 year(s) ago
Understanding a remarkable event at the start of life, the oocyte-to-embryo transition (OET), has remained elusive, especially in humans. Using newly developed techniques, Liu et al. showed that human maternal mRNAs undergo global poly(A) tail-mediated remodeling during OET, identified the enzymes involved, and demonstrated the essentiality of remodeling for embryo cleavage.
Source: Trends in GeneticsCategories: Genetics, Latest HeadlinesTweet
A gene on the X chromosome called UTX escapes inactivation, contributing to sex differences in natural killer cells between men and women. Thanks, Oscar Aguilar (@oaaguilar503), for spotlighting work by Tim O’Sullivan and Maureen Su (@Maureen_Su_Lab)! https://t.co/nEOMsf14SI