-
Mashup Score: 9Sex Differences in the Pre- and In-Hospital Setting of Patients With Stroke Are Driven by Higher Age and Stroke Severity | Stroke - 10 day(s) ago
BACKGROUND: Sex critically determines stroke pathophysiology and recovery. To reveal potential gaps in stroke care, we analyzed sex-specific differences in the stroke patient hospital admission and treatment process. METHODS: In this single-center retrospective analysis, we screened all patients referred to our stroke center between 2014 and 2020 with suspicion of stroke (n=7112). Patients with different cerebrovascular events and stroke mimics were included. We collected demographic hospitalization and 90-day follow-up data and stratified results according to sex. In a logistic regression analysis for 90-day functional outcome, we estimated the effect of sex corrected for the clinically most relevant confounders. RESULTS: Of 7102 patients, 56.7% were male and 43.3% female. Women were older (median, 76.3 years; interquartile range (IQR), 64–84, versus 70.7; IQR, 59–79; P<0.001), and lived more often in nursing homes before the event (10.5% versus 3.8%; P<0.001). Among patients with acu
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet
-
Mashup Score: 13
BACKGROUND: In acute stroke, diffusion-weighted imaging (DWI) is used to assess the ischemic core. Dynamic-susceptibility contrast perfusion magnetic resonance imaging allows an estimation of the oxygen extraction fraction (OEF), but the outcome of DWI lesions with increased OEF postrecanalization is unclear. This study investigated the impact of OEF on the fate of DWI lesions in patients achieving recanalization after thrombectomy. METHODS: This was a retrospective analysis of the HIBISCUS-STROKE cohort (Cohort of Patients to Identify Biological and Imaging Markers of Cardiovascular Outcomes in Stroke; NCT: 03149705), a single-center observational study that prospectively enrolled patients who underwent magnetic resonance imaging triage for thrombectomy and a day-6 T2-fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging. Automated postprocessing of admission dynamic-susceptibility contrast perfusion magnetic resonance imaging generated OEF maps. At visual analysis, t
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE Increased oxygen extraction fraction (OEF) in stroke patients post-MT is linked to better recovery of ischemic lesions, with reduced lesion volumes post-treatment. #AHAJournals @CHUdeLyon @HCL_research @Inserm @LaboratoryIris https://t.co/Bh5t7bjonT https://t.co/sBoaJNzwyB
-
-
Mashup Score: 10
BACKGROUND: Left ventricular diastolic dysfunction (DD) is associated with adverse cardiovascular outcomes including atrial fibrillation. Whether DD is independently associated with incident stroke and transient ischemic attack (TIA) and with bleeding events is not known. We performed this observational cohort analysis to examine the impact of DD on the risk of stroke/TIA and major bleeding. METHODS: Patients who underwent at least 1 cardiac echocardiogram and were followed for at least 3 months were included in this study. Patients with a prior history of stroke, TIA, or major bleeding, as determined by International Classifications of Diseases codes, were excluded. Smart key-phrase search was applied to echocardiographic reports to classify patients into 4 groups based on the most severe DD assessment. Patients in whom the presence of DD could not be determined were excluded. The final study cohort was followed to the end point of hospital admission for stroke/TIA and major bleeding,
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE: The risks of stroke and major bleeding increase with worsening grades of diastolic dysfunction, independent of history of atrial fibrillation. #AHA24 #AHAJournals @KrishKancharla @Aditi_Nani @Saba_sfs3 @PittCardiology https://t.co/GmGXmBYl0J https://t.co/uTs1Et84ep
-
-
Mashup Score: 55Article Commentary: “Anticoagulants versus Antiplatelet Treatment in the Medical Management of Carotid Floating Thrombus” - 11 day(s) ago
Carotid floating thrombus (CFT) is a rare but serious variant of intraluminal thrombus that is attached to the luminal side of the vessel at one end and free at the other end. This can present as an emergency due to the inherent risk of dislodgement and embolization causing recurrent stroke. Unfortunately, there is no consensus regarding the management of the same owing to the very small incidence in about 1.6% of all strokes. Many neurologists treat it with varying combinations of antiplatelets and
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Article Commentary: “Anticoagulants versus Antiplatelet Treatment in the Medical Management of Carotid Floating Thrombus” #BloggingStroke contributor Sucharita Ray discusses this @JSCVD2 article by Aboul-Nour et al. https://t.co/PkaU9zcNK5 https://t.co/A8Dx5ZNCa0
-
-
Mashup Score: 104Article Commentary: “Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site” - 14 day(s) ago
The role of endovascular thrombectomy (EVT) in acute ischemic stroke has been widely expanded over the last decade, with the extension of the time window up to 24 hours 1 and inclusion of patients with large ischemic cores. 2 However, recent evidence has largely focused on patients with anterior circulation large vessel occlusion. The optimal management of posterior cerebral artery (PCA) occlusions is not known, with variable effects on functional outcomes shown in previous studies. 3 The optimal managemen
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Article Commentary: “Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site” In this #BloggingStroke post, Chloe Mutimer discusses #Stroke article by Strambo et al. #AHAJournals https://t.co/4Vh4YHHOOK https://t.co/WA6tokjt3S
-
-
Mashup Score: 15World Stroke Congress 2024 Session Report: Plenary 02 - 18 day(s) ago
World Stroke Congress October 23 – 26, 2024 Session: Plenary 02: Plenary, Awards, & Late Breaking The session was chaired by Craig Anderson (Australia) and Shelia Martins (Brazil). Paul Whelton (New Orleans, USA) discussed the results from a systematic review and meta-analysis on the optimal antihypertensive systolic blood pressure. The primary analysis focused on studies with a systolic blood pressure goal lower than 130 mmHg, achieving a high quality of evidence and showing b enefit of a more (< 130
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
World Stroke Congress 2024 Session Report: Plenary 02 In our latest #BloggingStroke post, blog contributor @Theodorou_Aik recaps #WSC2024 plenary session chaired by Craig Anderson & @sheilambrasil. @SposatoL @WorldStrokeOrg https://t.co/6YboV6wz5x https://t.co/prhLHJmqfS
-
-
Mashup Score: 32Article Commentary: “LDL-c Lowering, Ischemic Stroke, and Small Vessel Disease Brain Imaging Biomarkers” - 18 day(s) ago
A Mendelian randomization (MR) study is a design that aims to provide evidence about putative causal relations between modifiable risk factors and disease, using genetic variants as natural experiments. This method is l ess susceptible to confounders compared to other observational studies. This study investigates the association between genetically predicted LDL-c, subtypes of ischemic stroke and imaging biomarkers — perivascular spaces (PVS) and white matter hyperintensity (WMH) volumes — in a two-sample
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Article Commentary: “LDL-c Lowering, Ischemic Stroke, and Small Vessel Disease Brain Imaging Biomarkers” In this #BloggingStroke post, Sucharita Ray discusses #Stroke article by @mariejoedib et al. #AHAJournals @dpsg108 @JulioChirinosMd https://t.co/PE3opOqFyr https://t.co/0rOGSBdVp1
-
-
Mashup Score: 16World Stroke Congress 2024 Session Report: Migraine and Stroke - 21 day(s) ago
World Stroke Congress October 23 – 26, 2024 The session was chaired by Eva Rocha (Brazil) and Simona Sacco (Italy). Luciano Sposato (Canada) opened by presenting retrospective literature showing clear association of stroke and migraine, particularly of migraine with aura, which has a 2-3-fold increased risk of stroke. However, he motivated the audience to scrutinize non-prospectively collected data as it may not necessarily be reliable. He illustrated his concern with a case study of a middle-aged female
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
World Stroke Congress 2024 Session Report: Migraine and Stroke In our latest #BloggingStroke post, Salome Bosshart recaps this #WSC2024 session chaired by @EvaRochaMD & @Simona_Sacco_. #stroke @WorldStrokeOrg @SposatoL https://t.co/faVhhL3qWc https://t.co/P0Ao7rReHn
-
-
Mashup Score: 10Building Academic Comprehensive Stroke Program in Ethiopia: A Model for Lower-Middle-Income Countries | Stroke - 22 day(s) ago
View all available purchase options and get full access to this article. Request permissions for this article. A list of all Axon Stroke and Spine Center Collaborators is given in the Appendix. For Sources of Funding and Disclosures, see page XXX. The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association. Correspondence to: Wondwossen G. Tekle, MD, Axon Stroke and Spine Center, Sunshine Real-Estate, W13, Meri-Lukie, Addis Ababa, Ethiopia. Email
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#InterSECT article by @wondeasa et al. appraises the challenges and opportunities in developing an academic #stroke program outside of high-income countries. #AHAJournals @AmeerEHassan https://t.co/AVArH9Be7i https://t.co/xIwOwgJFfk
-
-
Mashup Score: 2
Randomized trials in stroke often focus on outcomes beyond a single clinical event. Trials of stroke prevention commonly use composite outcomes that include multiple components (eg, death, stroke, or myocardial infarction). A major limitation is that all events count equally but may differ markedly in terms of clinical severity. Trials in acute stroke often use ordinal outcomes or scale scores. Limitations include the requirement for statistical assumptions and the difficulty of handling the competing risk of death. We introduce the win ratio as an alternative method. It works by placing components of a composite into a hierarchy, whereby clinically more important outcomes take priority over less important ones. We illustrate how it works using data from 2 major stroke trials: the ICSS (International Carotid Stenting Study, a trial in stroke prevention) and the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). Poten
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Topical Review by Gregson et al: Use of win ratio is flexible approach to clinical trial analysis because it permits emphasis of most important outcome(s) within composite and allows simultaneous treatment of competing risk of death. @dippel_diederik https://t.co/4JphuG0wHd https://t.co/xIHfTnDFL2
-
#STROKE: In a retrospective, observational cohort study of 7,102 patients, biological sex was not independently associated with functional outcomes at 90 days poststroke. #GoRedforWomen #AHAJournals @SuseWegener @GoRedForWomen https://t.co/1wmNZRGzFI https://t.co/6xM4BON4Pi