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Mashup Score: 12
BACKGROUND: Left ventricular diastolic dysfunction (DD) is associated with adverse cardiovascular outcomes including atrial fibrillation. Whether DD is independently associated with incident stroke and transient ischemic attack (TIA) and with bleeding events is not known. We performed this observational cohort analysis to examine the impact of DD on the risk of stroke/TIA and major bleeding. METHODS: Patients who underwent at least 1 cardiac echocardiogram and were followed for at least 3 months were included in this study. Patients with a prior history of stroke, TIA, or major bleeding, as determined by International Classifications of Diseases codes, were excluded. Smart key-phrase search was applied to echocardiographic reports to classify patients into 4 groups based on the most severe DD assessment. Patients in whom the presence of DD could not be determined were excluded. The final study cohort was followed to the end point of hospital admission for stroke/TIA and major bleeding,
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 4AHA24 - 7 day(s) ago
Download the mobile program today to easily access event session s, speakers, exhibitors, and organizer messages. Use the native app to personalize your schedule, take notes, share contacts, and more. Build your schedule directly on your computer. Then, install the native app and sync your schedule to your mobile
Source: eppro01.ativ.meCategories: General Medicine News, CardiologistsTweet-
Join #AHAJournals in celebrating the Dr. Nanette K. Wenger Research Goes Red® Award winner. #AHA24 Saturday, Nov 16 @ 9:45-11am CT Room: S100A https://t.co/9D7twutdPq
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Mashup Score: 4AHA24 - 7 day(s) ago
Download the mobile program today to easily access event session s, speakers, exhibitors, and organizer messages. Use the native app to personalize your schedule, take notes, share contacts, and more. Build your schedule directly on your computer. Then, install the native app and sync your schedule to your mobile
Source: eppro01.ativ.meCategories: General Medicine News, CardiologistsTweet-
Join #AHAJournals in celebrating the Dr. Nanette K. Wenger Research Goes Red® Award winner. #AHA24 Saturday, Nov 16 @ 9:45-11am CT Room: S100A https://t.co/9D7twutdPq
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Mashup Score: 68Anti-Inflammatory Thrombolytic JX10 (TMS-007) in Late Presentation of Acute Ischemic Stroke | Stroke - 8 day(s) ago
BACKGROUND: Contemporary thrombolytics in acute ischemic stroke are limited to administration within 4.5 hours of last known normal. JX10 (formerly TMS-007), a Stachybotrys microspora triprenyl phenol family member, may extend this therapeutic window. METHODS: In this multicenter, randomized, double-blind, placebo-controlled, dose-escalation phase 2a study, JX10 or placebo was administered as a single intravenous infusion to Japanese patients with acute ischemic stroke who were unable to receive tissue-plasminogen activator or thrombectomy within 12 hours of last known normal. Primary end point was incidence of symptomatic intracranial hemorrhage with a worsening National Institutes of Health Stroke Scale score of ≥4 points within 24 hours of drug administration (symptomatic intracranial hemorrhage incidence). RESULTS: Ninety patients received either placebo (n=38; female 26.3%) or JX10 at 1, 3, or 6 mg/kg (n=6, 18, 28; female 0%, 33.3%, and 42.9%, respectively). Median age (range) and
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE patients who were unable to receive tPA or EVT within 12 hours of last-known-well were randomized to JX10 (formerly TMS-007) or placebo. JX10 was well tolerated and showed higher likelihood of mRS 0-1 at 90d. #AHAJournals https://t.co/t2mmYYyyFQ https://t.co/ep8iDiEZPU
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Mashup Score: 29Article Commentary: “Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source” - 8 day(s) ago
Of all ischemic strokes, 17% are deemed embolic strokes of undetermined source (ESUS). 1 This is likely a heterogeneous group with several proposed etiologies, including non-stenotic or distant vessel atherosclerosis. Antiplatelet monotherapy is the de facto standard long-term antithrombotic for secondary prevention after ESUS given previous negative trials for anticoagulation in this setting. 2 The CHANCE-2 trial looked at patients with high-risk TIA (ABCD 2 ≥ 4) or minor stroke (NIHSS ≤ 3) and who were
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Article Commentary: “Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source” In this #BloggingStroke post, blog contributor George Xu discusses #Stroke article by Xie & Jing et al. #AHAJournals @ClayJohnstonMD https://t.co/MSM8qAcHOy https://t.co/kdJf6BOJ74
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Mashup Score: 16Menstruation: An Important Indicator for Assessing Stroke Risk and Its Outcomes | Stroke - 9 day(s) ago
In recent years, stroke incidence in older adults has declined strikingly, but stroke in younger women has become more common. Abnormalities of menstruation, the shedding of the uterine lining at the beginning of each menstrual cycle, may offer clues about stroke risk in young and midlife women. Endometrial and structural uterine abnormalities are associated with anemia and may be associated with hypercoagulability, possibly increasing stroke risk. Patient factors that influence both menstruation and stroke risk include coagulopathies, polycystic ovarian syndrome, endometriosis, migraine, and other systemic disorders, in addition to menopause. Environmental and iatrogenic factors that influence both menstruation and stroke risk include hormonal contraceptives, nicotine, xenoestrogens, phytoestrogens, oophorectomy, and hysterectomy. Importantly, secondary stroke prevention can affect menstruation. Our current review presents literature supporting the idea that abnormal menstruation may
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE Topical Review by Seitz & Raval critically appraises the literature examining the relationship between abnormal menstruation and stroke risk in premenopausal women. @UWNeurology @GoRedForWomen #GoRedforWomen #AHAJournals https://t.co/Du1u8DiFRK https://t.co/LMrMctrN55
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Mashup Score: 30Social Isolation Moderates the Relationship Between White Matter Hyperintensities and Dementia - 9 day(s) ago
Social isolation is an increasingly recognized risk factor for stroke and possibly for dementia, 1,2 but we lack data about how exactly social isolation might cause poor health outcomes. The current study by Eswaran et al. approaches social isolation and dementia using the Atherosclerosis Risk in Communities study. 3 All of the 1,617 included participants completed perceived social support and isolation scales at their second study visit, an MRI at their fifth study visit, and had neurocognitive evaluation
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Social Isolation Moderates the Relationship Between White Matter Hyperintensities and Dementia In this #BloggingStroke post, Alison Seitz discusses #Stroke article by Eswaran et al. #AHAJournals @chelsealiu96 @gottesman_lab https://t.co/gJtKZR6w8G https://t.co/OI5egvpQmM
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Mashup Score: 9Sex Differences in the Pre- and In-Hospital Setting of Patients With Stroke Are Driven by Higher Age and Stroke Severity | Stroke - 10 day(s) ago
BACKGROUND: Sex critically determines stroke pathophysiology and recovery. To reveal potential gaps in stroke care, we analyzed sex-specific differences in the stroke patient hospital admission and treatment process. METHODS: In this single-center retrospective analysis, we screened all patients referred to our stroke center between 2014 and 2020 with suspicion of stroke (n=7112). Patients with different cerebrovascular events and stroke mimics were included. We collected demographic hospitalization and 90-day follow-up data and stratified results according to sex. In a logistic regression analysis for 90-day functional outcome, we estimated the effect of sex corrected for the clinically most relevant confounders. RESULTS: Of 7102 patients, 56.7% were male and 43.3% female. Women were older (median, 76.3 years; interquartile range (IQR), 64–84, versus 70.7; IQR, 59–79; P<0.001), and lived more often in nursing homes before the event (10.5% versus 3.8%; P<0.001). Among patients with acu
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE: In a retrospective, observational cohort study of 7,102 patients, biological sex was not independently associated with functional outcomes at 90 days poststroke. #GoRedforWomen #AHAJournals @SuseWegener @GoRedForWomen https://t.co/1wmNZRGzFI https://t.co/6xM4BON4Pi
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Mashup Score: 13
BACKGROUND: In acute stroke, diffusion-weighted imaging (DWI) is used to assess the ischemic core. Dynamic-susceptibility contrast perfusion magnetic resonance imaging allows an estimation of the oxygen extraction fraction (OEF), but the outcome of DWI lesions with increased OEF postrecanalization is unclear. This study investigated the impact of OEF on the fate of DWI lesions in patients achieving recanalization after thrombectomy. METHODS: This was a retrospective analysis of the HIBISCUS-STROKE cohort (Cohort of Patients to Identify Biological and Imaging Markers of Cardiovascular Outcomes in Stroke; NCT: 03149705), a single-center observational study that prospectively enrolled patients who underwent magnetic resonance imaging triage for thrombectomy and a day-6 T2-fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging. Automated postprocessing of admission dynamic-susceptibility contrast perfusion magnetic resonance imaging generated OEF maps. At visual analysis, t
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE Increased oxygen extraction fraction (OEF) in stroke patients post-MT is linked to better recovery of ischemic lesions, with reduced lesion volumes post-treatment. #AHAJournals @CHUdeLyon @HCL_research @Inserm @LaboratoryIris https://t.co/Bh5t7bjonT https://t.co/sBoaJNzwyB
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Mashup Score: 10
BACKGROUND: Left ventricular diastolic dysfunction (DD) is associated with adverse cardiovascular outcomes including atrial fibrillation. Whether DD is independently associated with incident stroke and transient ischemic attack (TIA) and with bleeding events is not known. We performed this observational cohort analysis to examine the impact of DD on the risk of stroke/TIA and major bleeding. METHODS: Patients who underwent at least 1 cardiac echocardiogram and were followed for at least 3 months were included in this study. Patients with a prior history of stroke, TIA, or major bleeding, as determined by International Classifications of Diseases codes, were excluded. Smart key-phrase search was applied to echocardiographic reports to classify patients into 4 groups based on the most severe DD assessment. Patients in whom the presence of DD could not be determined were excluded. The final study cohort was followed to the end point of hospital admission for stroke/TIA and major bleeding,
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE: The risks of stroke and major bleeding increase with worsening grades of diastolic dysfunction, independent of history of atrial fibrillation. #AHA24 #AHAJournals @KrishKancharla @Aditi_Nani @Saba_sfs3 @PittCardiology https://t.co/GmGXmBYl0J https://t.co/uTs1Et84ep
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#STROKE: The risks of stroke and major bleeding increase with worsening grades of diastolic dysfunction, independent of history of atrial fibrillation. #AHA24 #AHAJournals @KrishKancharla @Aditi_Nani @Saba_sfs3 @PittCardiology https://t.co/GmGXmBYl0J https://t.co/uTs1Et84ep