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Mashup Score: 9
Nature – Extrachromosomal DNA makes cancerous tumours resistant to treatment, but this research demonstrates that increasing transcription–replication conflict allows for targeted elimination…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 20Mapping spatial organization and genetic cell-state regulators to target immune evasion in ovarian cancer - 3 month(s) ago
Nature Immunology – Here the authors provide a resource for ovarian cancer combining spatial transcriptomics, genomics, CRISPR Perturb-seq screens and in silico methods to focus on T cells and…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
SCI members @LivnatJerby, @BrookeHowittMD, and others utilized SspatialTranscriptomics, and #CRISPR screens to uncover mechanisms of immune evasion in #OvarianCancer. https://t.co/qgw1dimJIq https://t.co/GZxZWAGPEH
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Mashup Score: 11Coordinated inheritance of extrachromosomal DNAs in cancer cells - 3 month(s) ago
Nature – Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
SCI members @HowardYChang, @mischellab & collaborators discovered that #ecDNA transcription persists during cell division, allowing ecDNAs to stay interconnected, & segregating together as multi-circle units into daughter cells. https://t.co/zW5FCHupZW https://t.co/AuxirWMnhI
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Mashup Score: 16Origins and impact of extrachromosomal DNA - 3 month(s) ago
Nature – A study examines the diversity of extrachromosomal DNA elements in cancer, and provides details on the frequency and origin of extrachromosomal DNA and its role in the development of…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
SCI members @HowardYChang & @mischellab found that 17.1% of tumors contained #ecDNA. ecDNA was > after targeted therapy or cytotoxic treatments. The presence of ecDNA was associated with metastasis & poorer overall survival. https://t.co/JywRHiFKQ2 https://t.co/soDnIzM17g
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Mashup Score: 2Automated patient selection and care coaches to increase advance care planning for cancer patients - 3 month(s) ago
AbstractBackground. Advance care planning/serious illness conversations can help clinicians understand patients’ values and preferences. There are limited
Source: academic.oup.comCategories: General Medicine News, Oncologists1Tweet-
SCI members Michael Gensheimer, Kavitha Ramchandran, & others found that combining machine learning-based nudges, provider education, and care coach support increased #AdvanceCarePlanning conversations. https://t.co/GIo7NFrMTI @MFGensheimer https://t.co/0Q0K9fiYzI
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Mashup Score: 2Automated patient selection and care coaches to increase advance care planning for cancer patients - 3 month(s) ago
AbstractBackground. Advance care planning/serious illness conversations can help clinicians understand patients’ values and preferences. There are limited
Source: academic.oup.comCategories: General Medicine News, Oncologists1Tweet-
SCI members Michael Gensheimer, Kavitha Ramchandran, & others found that combining machine learning-based nudges, provider education, and care coach support increased #AdvanceCarePlanning conversations. https://t.co/GIo7NFrMTI @MFGensheimer https://t.co/0Q0K9fiYzI
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Mashup Score: 15
Abstract. Oncogene amplification on extrachromosomal DNA (ecDNA) is a pervasive driver event in cancer, yet our understanding of how ecDNA forms is limited. Here, we couple a CRISPR-based method for ecDNA induction with extensive characterization of newly formed ecDNA to examine their biogenesis. We find that DNA circularization is efficient, irrespective of 3D genome context, with formation of 800kb, 1 Mb, and 1.8 Mb ecDNAs reaching or exceeding 15%. We show non-homologous end joining and microhomology-mediated end joining both contribute to ecDNA formation, while inhibition of DNA-PKcs and ATM have opposing impacts on ecDNA formation. EcDNA and the corresponding chromosomal excision scar can form at significantly different rates and respond differently to DNA-PKcs and ATM inhibition. Taken together, our results support a model of ecDNA formation in which double strand break ends dissociate from their legitimate ligation partners prior to joining of illegitimate ends to form the ecDNA
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet-
SCI members @HowardYChang, Paul Mischel, and others found support a model of #ecDNA formation in which double strand break ends dissociate from their legitimate ligation partners prior to joining of illegitimate ends to form the ecDNA and excision scar. https://t.co/NeTy66QHYT https://t.co/s6vHgp0eF3
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Mashup Score: 4
This cohort study examines the association of insurance status with hospital quality and receipt of guideline-compliant care among patients with head and neck cancer.
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet-
SCI member Uchechukwu Megwalu found that insurance status contributes to considerable disparities in care quality for patients with #HeadandNeckCancer. https://t.co/lANrtqWXxd #HealthEquity
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Mashup Score: 12Small Cell Lung Cancer Neuronal Features and Their Implications for Tumor Progression, Metastasis, and Therapy - 4 month(s) ago
Abstract. Small cell lung cancer (SCLC) is an epithelial neuroendocrine form of lung cancer for which survival rates remain dismal and new therapeutic approaches are greatly needed. Key biological features of SCLC tumors include fast growth and widespread metastasis, as well as rapid resistance to treatment. Similar to pulmonary neuroendocrine cells, SCLC cells have traits of both hormone-producing cells and neurons. In this study, we specifically discuss the neuronal features of SCLC. We consider how neuronal G protein–coupled receptors and other neuronal molecules on the surface of SCLC cells can contribute to the growth of SCLC tumors and serve as therapeutic targets in SCLC. We also review recent evidence for the role of neuronal programs expressed by SCLC cells in the fast proliferation, migration, and metastasis of these cells. We further highlight how these neuronal programs may be particularly relevant for the development of brain metastases and how they can assist SCLC cells t
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
SCI member @SageJulien and @stanfordcbio's @griffinhartmann examine neuronal features of #SCLC and their impact on tumor progression, metastasis, and treatment strategies. https://t.co/j2TXDwMFUG https://t.co/eLLHLpsrwE
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Mashup Score: 5Stanford Medicine Radiology Awarded Up to $35 million from ARPA-H to Advance Precision Cancer Imaging and Therapy - 4 month(s) ago
September 19, 2024
Source: med.stanford.eduCategories: General Medicine News, Oncologists1Tweet-
SCI member Katherine Ferrara and her team have been awarded a $35M federal contract from @ARPA_H to innovate precision #radiopharmaceutical imaging and therapy. https://t.co/fACsUVA676 @StanfordRad
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SCI members @HowardYChang, @mischellab, and others found that blocking #CHK1 activity leads to death of #ecDNA containing tumor cells and tumor regression in mice with a gastric tumor driven by DNA circles. https://t.co/5LPSWh4um6 https://t.co/XAI0MfbWTm