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Mashup Score: 33
PURPOSE Chemotherapy is established as primary treatment in patients with stage IV colorectal cancer and unresectable metastases. Data from nonrandomized clinical trials have fueled persistent uncertainty if primary tumor resection (PTR) before chemotherapy prolongs survival. We investigated the prognostic value of PTR in patients with newly diagnosed stage IV colon cancer who were not amenable to curative treatment. PATIENTS AND METHODS Patients enrolled in the multicenter, randomized SYNCHRONOUS and CCRe-IV trials were included in the analysis. Patients with colon cancer with synchronous unresectable metastases were randomly assigned at 100 sites in Austria, Germany, and Spain to undergo PTR or up-front chemotherapy (No PTR group). The chemotherapy regimen was left at discretion of the local team. Patients with tumor-related symptoms, inability to tolerate surgery and/or systemic chemotherapy, and history of another cancer were excluded. The primary end point was overall survival (OS
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 42024 Advanced Prostate Cancer Consensus Conference (APCCC) - 7 day(s) ago
Were you unable to attend APCCC 2024? Get all of the groundbreaking research, new guidelines, and the latest advances in urologic medicine you missed.
Source: www.urotoday.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
Nature Metabolism – Veniant et al. report here on a GIPR antagonist conjugated to GLP-1 analogues that reduces body weight and improves metabolic markers in preclinical and phase 1 clinical settings.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 33
PURPOSE Chemotherapy is established as primary treatment in patients with stage IV colorectal cancer and unresectable metastases. Data from nonrandomized clinical trials have fueled persistent uncertainty if primary tumor resection (PTR) before chemotherapy prolongs survival. We investigated the prognostic value of PTR in patients with newly diagnosed stage IV colon cancer who were not amenable to curative treatment. PATIENTS AND METHODS Patients enrolled in the multicenter, randomized SYNCHRONOUS and CCRe-IV trials were included in the analysis. Patients with colon cancer with synchronous unresectable metastases were randomly assigned at 100 sites in Austria, Germany, and Spain to undergo PTR or up-front chemotherapy (No PTR group). The chemotherapy regimen was left at discretion of the local team. Patients with tumor-related symptoms, inability to tolerate surgery and/or systemic chemotherapy, and history of another cancer were excluded. The primary end point was overall survival (OS
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 10Stark law: 10 critical changes in 3 years - 8 day(s) ago
“Stay updated on the latest changes to Stark law with these 10 updates reported by Becker’s, including a record $12.56 million in settlements and new exceptions
Categories: General Medicine News, Hem/OncsTweet
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Mashup Score: 12AJCC Cancer Staging System Version 9: Appendiceal Adenocarcinoma - 10 day(s) ago
Annals of Surgical Oncology –
Source: link.springer.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 72A Doctor at Cigna Said Her Bosses Pressured Her to Review Patients’ Cases Too Quickly. Cigna Threatened to Fire Her. - 11 day(s) ago
Cigna tracks every minute that its staff doctors spend deciding whether to pay for health care. Dr. Debby Day said her bosses cared more about being fast than being right: “Deny, deny, deny. That’s how you hit your numbers,” Day said.
Source: www.propublica.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 72A Doctor at Cigna Said Her Bosses Pressured Her to Review Patients’ Cases Too Quickly. Cigna Threatened to Fire Her. - 12 day(s) ago
Cigna tracks every minute that its staff doctors spend deciding whether to pay for health care. Dr. Debby Day said her bosses cared more about being fast than being right: “Deny, deny, deny. That’s how you hit your numbers,” Day said.
Source: www.propublica.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 72A Doctor at Cigna Said Her Bosses Pressured Her to Review Patients’ Cases Too Quickly. Cigna Threatened to Fire Her. - 12 day(s) ago
Cigna tracks every minute that its staff doctors spend deciding whether to pay for health care. Dr. Debby Day said her bosses cared more about being fast than being right: “Deny, deny, deny. That’s how you hit your numbers,” Day said.
Source: www.propublica.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 5The risk of thrombosis in essential thrombocythemia is associated with the type of CALR mutation: A multicentre collaborative study - PubMed - 12 day(s) ago
Our results suggest that CALR mutation type has prognostic value for the stratification of thrombotic risk in ET patients.
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
RT @ArndtVogel: Primary Tumor Resection Before Systemic Therapy in CRC & Unresectable Metastases @JCO_ASCO https://t.co/FCqc7D7cjZ 🔎SYNCHR…