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Mashup Score: 28Head‐to‐head: Should Ki67 proliferation index be included in the formal classification of pulmonary neuroendocrine neoplasms? - 4 day(s) ago
The pros and cons on the use of Ki-67 in the classification and clinical practice of lung neuroendocrine neoplasms are reviewed herein. As mitotic count is a cornerstone in the classification and Ki-…
Source: onlinelibrary.wiley.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9
Aim We aimed to evaluate the prevalence of incidental 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT (SSTR PET/CT) findings, their clinical significance in the need for follow-up, and their risk of malignancy. Materials and methods Studies reporting incidental SSTR PET/CT findings were systematically searched in PubMed, Cochrane, Embase and Web of Science literature published prior to 1st of May 2020. Studies were filtered by two independent readers for eligibility based on title and abstract, and subsequently on full text. The main exclusion criteria were: 1) pathological findings that matched scan indication, 2) known organ specific disease and/or incidental findings confirmed on other scan modality prior to SSTR PET/CT, 3) lack of diagnosis and/or follow up, and 4) results published in proceedings or conference abstracts. Results Twenty-one studies, comprising a total of 2906 subjects, were eligible for the analysis. Studies included were retrospective cohort s
Categories: General Medicine News, Hem/OncsTweet
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Mashup Score: 81Neuroendocrine Tumors of Unknown Primary in the Setting of Cytoreductive Hepatectomy - 11 day(s) ago
Annals of Surgical Oncology – Surgical cytoreduction for neuroendocrine tumor liver metastasis (NETLM) consistently shows positive long-term outcomes. Despite reservations in guidelines for surgery…
Source: link.springer.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 34Relationship Between Absorbed Dose and Response in Neuroendocrine Tumors Treated with [177Lu]Lu-DOTATATE - 12 day(s) ago
Peptide receptor radionuclide therapy presents the possibility of tracing and quantifying the uptake of the drug in the body and performing dosimetry, potentially allowing individualization of treatment schemes. However, the details of how neuroendocrine tumors (NETs) respond to different absorbed doses are insufficiently known. Here, we investigated the relationship between tumor-absorbed dose and tumor response in a cohort of patients with NETs treated with [177Lu]Lu-DOTATATE. Methods: This was a retrospective study based on 69 tumors in 32 patients treated within a clinical trial. Dosimetry was performed at each cycle of [177Lu]Lu-DOTATATE, rendering 366 individual absorbed dose assessments. Hybrid planar–SPECT/CT imaging using [177Lu]Lu-DOTATATE was used, including quantitative SPECT reconstruction, voxel-based absorbed dose rate calculation, semiautomatic image segmentation, and partial-volume correction. Changes in tumor volume were used to determine tumor response. The volume fo
Source: jnm.snmjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
The composer Ludwig van Beethoven’s health issues throughout his life are well documented, with many conjectures on the cause of his death from liver and k
Source: academic.oup.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 51Value of Surgical Cytoreduction in Patients with Small Intestinal Neuroendocrine Tumors Metastatic to the Liver and Peritoneum - 16 day(s) ago
Annals of Surgical Oncology – Cytoreductive hepatectomy can improve survival and symptoms of hormonal excess in patients with small intestinal neuroendocrine tumor (siNET) liver metastases, but…
Source: link.springer.comCategories: General Medicine News, Oncologists2Tweet-
Surgery for liver AND peritoneal NET mets...? Another excellent study led by @HallberaG. Long-term OS and symptom control outcomes favorable. Better OS was associated with more cytoreduction. Peritoneal mets per se should not preclude surg cytoreduction https://t.co/VgZnKglzyu https://t.co/NlSPbRj1iA
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Mashup Score: 49
CA: A Cancer Journal for Clinicians is ACS’ flagship clinical oncology journal publishing information about the prevention, early detection, and treatment of cancer.
Categories: General Medicine News, Hem/OncsTweet
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Mashup Score: 48
CA: A Cancer Journal for Clinicians is ACS’ flagship clinical oncology journal publishing information about the prevention, early detection, and treatment of cancer.
Categories: General Medicine News, Hem/OncsTweet
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Mashup Score: 54 Zebras Broke Free on a Highway. A Rodeo Clown Stepped In. - 21 day(s) ago
One zebra was still on the loose, after it and three others escaped a trailer in North Bend, Wash. Dozens of people scrambled to help and corralled some of the animals.
Source: www.nytimes.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 46
CA: A Cancer Journal for Clinicians is ACS’ flagship clinical oncology journal publishing information about the prevention, early detection, and treatment of cancer.
Categories: General Medicine News, Hem/OncsTweet
A very good pro and con discussion of the use of Ki-67 in lung NETs. While not a perfect marker, I think the WHO classification of lung NENs would be improved by incorporating Ki67 but both authors (pro and con) make great points as expected. https://t.co/HyRj1PuaaY