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Mashup Score: 59Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis - 2 month(s) ago
Nature Neuroscience – Hematopoietic cell transplantation (HCT) may be a promising therapy for treatment-refractory multiple sclerosis (MS). Mader et al. Describe beneficial effects of autologous…
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Mashup Score: 101The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions - 2 month(s) ago
Nature Neuroscience – Chen et al. show that transitions to innate behaviors, such as feeding and social interaction, rely on their encoding during beta oscillations by neuron populations in the…
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Mashup Score: 134
Nature Neuroscience – Cortical excitatory neurons are narrowly tuned to sensory inputs, but the tuning of interneurons is perceived as broad and irregular. Duszkiewicz et al. demonstrate that…
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Mashup Score: 118Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics - 2 month(s) ago
Nature Neuroscience – A real-time analysis system was developed for an up to 500-megabyte-per-second image stream. This system can extract activities from up to 100,000 neurons in larval zebrafish…
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Mashup Score: 21The kainate receptor GluK2 mediates cold sensing in mice - 2 month(s) ago
Nature Neuroscience – The identity of receptors sensing cold temperatures in peripheral somatosensory neurons remains obscure. Cai et al. report that GluK2, a kainate receptor mediating synaptic…
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Mashup Score: 114Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics - 2 month(s) ago
Nature Neuroscience – A real-time analysis system was developed for an up to 500-megabyte-per-second image stream. This system can extract activities from up to 100,000 neurons in larval zebrafish…
Source: www.nature.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 156
Nature Neuroscience – This study investigates self-paced actions in freely foraging macaques. Findings highlight continuously evolving neural components that capture beliefs about latent reward…
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Mashup Score: 28A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity - Nature Neuroscience - 2 month(s) ago
Astrocytes have important roles in disease. However, modulation of their reactive state is challenging. Here the authors present a phenotypic in vitro screening platform they can leverage to identify chemical compounds able to modulate astrocyte reactivity in vitro and in vivo.
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Mashup Score: 29Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19 - Nature Neuroscience - 3 month(s) ago
Radke et al. found an interferon response in the brainstem nuclei of acute COVID-19 that, in addition to the inflammatory reaction, spreads throughout the vascular unit altering glial cells and resolves in late disease states in the absence of brain infection.
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Mashup Score: 191
If barrier controlling substances entering and exiting brain is off balance, it can drive changes in neural function
Source: www.theguardian.comCategories: General Medicine News, NeurologyTweet
Hematopoietic cell transplantation in multiple sclerosis (#MS) model mice increases a neuroprotective myeloid state, improves neurological deficits, and reduces demyelinated lesions, effector T cells, and reactive astrogliosis @marius_mader @WernigLab https://t.co/ak4MgwUglN