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Mashup Score: 8
*Nature Reviews Nephrology* welcomes you to this webinar, in which our two speakers — Leo Celi and Kianoush Kashani — will present on the…
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Mashup Score: 178Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury - Nature Reviews Nephrology - 2 month(s) ago
Immune checkpoint inhibitors are increasingly used as anti-cancer treatments; however, their use can be associated with the development of immune-related adverse events, including acute kidney injury. This Review describes the symptoms, biochemical signs and possible underlying mechanisms of immune checkpoint inhibitor-associated acute kidney injury, and proposes an approach to its diagnosis and…
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Mashup Score: 97Long-term health outcomes associated with hydration status - 2 month(s) ago
Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the composition of extracellular and intracellular fluids. Water balance is maintained by multiple mechanisms that continuously match water losses through urine, the skin, the gastrointestinal tract and respiration with water gains achieved through drinking, eating and metabolic…
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Mashup Score: 124
Kidney disease affects more than 10% of the global population and is associated with considerable morbidity and mortality, highlighting a need for new therapeutic options. Engineered nanoparticles for the treatment of kidney diseases (renal nanomedicines) represent one such option, enabling the delivery of targeted therapeutics to specific regions of the kidney. Although they are underdeveloped…
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Mashup Score: 18Nature Reviews Nephrology - Volume 20 Issue 3, March 2024 - 2 month(s) ago
Advancing equitable access to care, inspired by the Comment articles for World Kidney Day starting on p147.
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In our March issue, we celebrate #WorldKidneyDay with Comment articles on strategies to advance equitable access to kidney care, a Viewpoint on emerging therapies for DKD, plus Reviews on clonal haematopoiesis, TRPM channels & #AKI in patients with burns https://t.co/dt1wgwWL35 https://t.co/HwyXk52b1y
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Mashup Score: 17The genetics and pathogenesis of CAKUT - Nature Reviews Nephrology - 3 month(s) ago
Here, the authors provide an overview of genetic causes of CAKUT and their impact on signalling pathways during nephrogenesis. They also discuss the impact of a molecular genetic diagnosis on the clinical care and potentially the personalized treatment of patients with CAKUT.
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Mashup Score: 80Activation and regulation of alloreactive T cell immunity in solid organ transplantation - Nature Reviews Nephrology - 3 month(s) ago
Alloimmune T cell responses have a crucial role in graft rejection. Here, the authors examine the factors that regulate T cell activation, differentiation and function in secondary lymphoid organs and in the graft, including the different pathways of allorecognition, innate–adaptive immunity crosstalk and the role of survival cytokines.
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Mashup Score: 79Immunometabolic rewiring of tubular epithelial cells in kidney disease - Nature Reviews Nephrology - 3 month(s) ago
The interplay between immunological and metabolic processes is important in a variety of processes. This Review describes how changes in lipid and energy metabolism, driven by receptors of the innate immune system, contribute to the response of tubule epithelial cells to injury and the functional consequences of these intersecting pathways in kidney health and disease.
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Mashup Score: 66
Complement proteins and receptors with intracellular activity — the complosome — have emerged as important regulators of physiological processes. In this Review, the authors examine evidence of complosome activity across a variety of cells and tissues, as well as their contributions to human disease and therapeutic potential.
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Mashup Score: 27Network medicine: an approach to complex kidney disease phenotypes - Nature Reviews Nephrology - 3 month(s) ago
In this Review, the authors describe biological networks, discuss the properties that make these networks ideal for understanding how diseases arise from complex interactions of molecular and cellular systems, and explore how network medicine can be used to improve understanding of kidney and renovascular diseases.
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On World Kidney Day 2024 join us for a webinar on "Digital Determinants of Health: AI and the need for equity-focused innovation in digital health" with talks by Leo Celi and Kianoush Kashani 🗓️ Thur 14th Mar 2024 ⏲️ 11 AM (EDT)/ 3 PM (GMT)/ 5PM (CAT) https://t.co/cXQieUxrzk