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Mashup Score: 0Clinical and molecular correlates of somatic and germline DDX41 variants in patients and families with myeloid neoplasms - PubMed - 12 month(s) ago
The diagnosis of germline predisposition to myeloid neoplasms (MN) secondary to DDX41 variants is currently hindered by the long latency period, variable family histories and the frequent occurrence of DDX41 variants of uncertain significance (VUS). We reviewed 4,524 consecutive patients who underwe …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0The transcriptional and regulatory identity of erythropoietin producing cells - Nature Medicine - 1 year(s) ago
Single-cell analyses in a reporter mouse model and human tissues identify a rare cell subset that produces erythropoietin in vivo, opening potential new avenues for research in erythropoiesis and oxygen homeostasis.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
The transcriptional and regulatory identity of erythropoietin producing cells | Nature Medicine | #Norncells #sourceofEpo | Named after Norse goddesses of fate - named Urd, Verdandi, and Skuld #EPO #MDS @MPAlexanderMD https://t.co/9qW6VH97Y0
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Mashup Score: 1The elements, in haiku - 1 year(s) ago
An interactive review of the periodic table — composed of 119 haiku
Source: vis.sciencemag.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Elemental haiku @DavidSteensma . This is awesome! Check out lutetium @AlanBryce9 @Yael_Kusne https://t.co/2dwLD5GQ3g
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Mashup Score: 0Epic, Microsoft bring GPT-4 to EHRs - 1 year(s) ago
Health systems using Epic’s EHR system will be able to run generative AI solutions like GPT-4 through Microsoft’s OpenAI Azure Service.
Source: Modern HealthcareCategories: Hem/Oncs, Latest HeadlinesTweet-
Epic, Microsoft bring GPT-4 to EHRs https://t.co/P0WMJq2wku via @modrnhealthcr
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Mashup Score: 6Speed reading the epigenome and genome - Nature Biotechnology - 1 year(s) ago
Dual sequencing of the epigenome and genome could have broad implications in oncology.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @AlbertVilella: Dual sequencing of the epigenome and genome could have broad implications in oncology. https://t.co/0loBAFi8Vv
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Mashup Score: 5Spectrum of clonal hematopoiesis in VEXAS syndrome - PubMed - 1 year(s) ago
VEXAS is caused by somatic mutations in UBA1 (UBA1mut) and characterized by heterogenous systemic auto-inflammation and progressive hematologic manifestations, meeting criteria for myelodysplastic syndrome (MDS) and plasma cell dyscrasias. The landscape of myeloid-related gene mutations leading to t …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Spectrum of clonal hematopoiesis in VEXAS syndrome. https://t.co/Bd4DrIB4ul #UBA1 #CH #DNMT3A #TET2 @bhavishap29 @MayoCancerCare @NIH Fernanda Gutierrez @Yael_Kusne #singlecellproteogenome #VEXAS @VEXASfoundation @NealSYoung1 Grateful for this collaboration
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Mashup Score: 9Pulmonary manifestations in VEXAS syndrome - PubMed - 1 year(s) ago
The pulmonary manifestations in VEXAS are relatively nonspecific and nonsevere, occur in the context of systemic inflammation and are responsive to escalation in glucocorticoid dosing.
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Pulmonary manifestations in VEXAS syndrome. https://t.co/j0MkfkbbVz @MayoCancerCare @martacasalmoura @MdWarrington
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Mashup Score: 2Lung adenocarcinoma promotion by air pollutants - Nature - 1 year(s) ago
Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Lung adenocarcinoma promotion by air pollutants | Nature https://t.co/lvHKh0Souh
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Mashup Score: 0
In humans, we observe patients with CMD are more likely to have CHIP, and nearly one-third of major adverse cardiovascular events in CMD are mediated by CH.
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Clonal Hematopoiesis of Indeterminate Potential Is Associated With Coronary Microvascular Dysfunction In Early Nono… https:// https://t.co/3ckf6v6n44 @MayoCancerCare @MayoClinicCIM @LashoTerra @ZhuoerXie #CHIP #Coronarymicrodysfunction @NadiaAkhiyatMD @MayoClinicCV
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Mashup Score: 22
As of now, there is limited prospective data for CH testing; however, CH detection is becoming increasingly prevalent due to ubiquitous use of somatic and germline NGS testing. This in addition to data suggesting that therapy related myeloid neoplasm (tMN) in many cases is preceded by the detection …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance: 2023 update on … https://t.co/wCHqYYjNDn @a_mangaonkar @MayoCancerCare @MayoClinicCIM #CHIP #CCUS
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Clinical and molecular correlates of somatic and germline DDX41 variants in patients and families with myeloid neop… https://t.co/NzU11mvzz7 @TalhaBadarMD @DrAlexFerrer @tchlon #DDX41 #MDS @MayoCancerCare @MayoCancerCare