• Mashup Score: 2

    Background and objectives Kidney biopsy is the current gold standard to diagnose membranous nephropathy. Approximately 70%–80% of patients with primary membranous nephropathy have circulating anti-phospholipase A2 receptor antibodies. We previously demonstrated that in proteinuric patients with preserved eGFR and absence of associated conditions ( e.g., autoimmunity, malignancy, infection, drugs,…

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    • More evidence that kidney biopsy can be abandoned if there is overwhelming clinical suspicion for #MembranousNephropathy (preserved eGFR, no associated conditions or diabetes, (+)anti-PLA2R >20 RU/ml or positive IF) 👏👏 https://t.co/6h8Uxs7MUI https://t.co/MHlaZgfOmT

  • Mashup Score: 3

    Cognitive decline is common in chronic kidney disease (CKD). While the evidence of vascular cognitive impairment in this population is robust, the role of Alzheimer’s pathology is unknown. We evaluated serum cystatin C-estimated glomerular filtration rate (eGFR), brain amyloid-β positron emission tomography (PET) imaging, and cognitive function in 166 participants from The 90+ Study. Mean age was…

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    • Our new brief report from unique The 90+ Study cohort: Kidney function (measured by cystatin C) was not related to brain amyloid burden (assessed on amyloid PET brain imaging) https://t.co/afzFGInMGG #CKD #brainhealth #FOAMed @FrontMedicine @UCIkidney https://t.co/bSdcrT8WB2

  • Mashup Score: 0

    The endothelial cells which form the inner cellular lining of the vasculature can act as non-professional phagocytes to ingest and remove emboli and aged/injured red blood cells (RBCs) from circulation. We previously demonstrated an erythrophagocytic phenotype of the brain endothelium for oxidatively stressed RBCs with subsequent migration of iron-rich RBCs and RBC degradation products across the…

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    • Insights Into the Mechanisms of Brain Endothelial Erythrophagocytosis Fabulous work from collaborators at Chapman University @ChapmanU Leads to microhemorrhage-like lesions in vivo (mimicking microbleeds) https://t.co/sxtXvEp8Ln https://t.co/eBFOhAFLJ0