Cutaneous T-cell lymphomas are characterized by heterogeneity of clinical variants, further complicated by genomic and microenvironmental variables. Furthermore, in vitro experiments are hampered by the low culture efficiency of these malignant cells. Animal models are essential for understanding the pathogenetic mechanisms underlying malignancy and for discovering new anticancer treatments. They…

It has been over a decade and a half since the first large-scale study of the accelerated risk of myocardial infarction in psoriasis (Gelfand et al., 2006). Since then, a broad range of scientific approaches has determined that psoriasis itself is associated with a higher-risk subclinical vascular disease (Naik et al., 2015), high-risk coronary plaque (Lerman et al., 2017), and major adverse…

Basal keratinocytes (KCs) attach to the extracellular matrix (ECM) through complexes that include hemidesmosomes (HDs) (Tsuruta et al., 2011). In the skin, HDs consist of transmembrane proteins (α6β4 integrin, collagen XVII [COL17], CD151), matrix proteins (laminin 332), and cytoplasmic proteins (plectin, BP230) and connect keratin filaments and ECM (Figure 1). In homeostatic conditions, HDs…

Traditional immunohistochemistry (IHC) is inherently limited by its ability to analyze only several markers within a histological tissue section at a given time, which hinders in-depth characterization and phenotyping of tissues. Imaging mass cytometry (IMC), which combines IHC using metal-labeled antibodies with laser ablation and detection using mass cytometry by time-of-flight, overcomes this…

In their report, Chen et al. provide new insights into psoriasis pathogenesis, showing that neutrophil infiltration of skin lesions increases vascular endothelial cell (VEC) activation, leading to cutaneous vasodilation and enhanced vascular permeability. In patients with psoriasis, neutrophil-derived matrix metalloproteinase 9 (MMP-9) plays a pivotal role in VEC barrier dysfunction, via…

Integrin α3β1 plays a crucial role in tumor formation in the two-stage chemical carcinogenesis model (DMBA and TPA treatment). However, the mechanisms whereby the expression of α3β1 influences key oncogenic drivers of this established model are not known yet. Using an in vivo mouse model with epidermal deletion of α3β1 and in vitro Matrigel cultures of transformed keratinocytes, we demonstrate…

Skin squamous cell carcinomas (SCCs) are a major cause of death in patients who have undergone or will undergo organ transplantation. Moreover, these neoplasms cause significant disease and economic burden and diminish patients’ life quality. However, no effective treatment or intervention strategies are available. In this study, we investigated the pathologic role of 5′-cap translation, which is…