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Mashup Score: 14Comprehensive characterisation of acinar cystic transformation of the pancreas: a systematic review - 15 day(s) ago
Aims Acinar cystic transformation (ACT) of the pancreas is a rare pancreatic cystic lesion. Owing to its rarity, comprehensive histomolecular characterisation of this entity is still lacking. We aim to perform a systematic review on this controversial entity. Methods We searched PubMed, SCOPUS and Embase through May 2023 to identify all studies on ACTs. Clinicopathological, immunohistochemical (IHC) and molecular data have been extracted and analysed. Results Overall, there were 121 cases of ACTs in the literature. ACT had a female predominance (65.3% of patients), and a mean size of 4.8 cm. ACT was more often unifocal (71.9%) and multiloculate (61.2%). Histologically, the cysts were lined by an acinar epithelium, sometimes harbouring ductal-like areas (18.2%). In five cases (4.1%), an intralesional pancreatic intraepithelial neoplasia (PanIN) was reported. Preoperative diagnosis is challenging. After surgical resection, all patients were alive and disease free during follow-up except
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 26Journal of Clinical Pathology: 77 (3) - 20 day(s) ago
(12 December, 2023) Jeremy Adler, Khaled Algashaamy, Monica T Garcia de Buitrago, Andre Pinto, Elizabeth Anne Montgomery (24 November, 2023) Alexander T Kikuchi, Naoki Akanuma, Won-Tak Choi, Ryan M Gill, Sanjay Kakar (20 December, 2023) Neil A Shepherd (22 November, 2023) Free Murali Varma, Laura C Collins, Runjan Chetty, Dipti M Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D Guzmán-Arocho, Adam V Jones, Miranda Pring, W Glenn McCluggage (19 February, 2024) Monika Vyas,
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
⭐ MACROSCOPIC PATHOLOGY⭐ If you haven't read our March 2024 issue on Macroscopic Pathology https://t.co/gMEt7GAOde, here's another opportunity. Two-day seminar organized by Dr. Murali Varma. And it's free! Register now! @MuraliV72899596 https://t.co/9owEjglUGE
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Mashup Score: 26Journal of Clinical Pathology: 77 (3) - 20 day(s) ago
(12 December, 2023) Jeremy Adler, Khaled Algashaamy, Monica T Garcia de Buitrago, Andre Pinto, Elizabeth Anne Montgomery (24 November, 2023) Alexander T Kikuchi, Naoki Akanuma, Won-Tak Choi, Ryan M Gill, Sanjay Kakar (20 December, 2023) Neil A Shepherd (22 November, 2023) Free Murali Varma, Laura C Collins, Runjan Chetty, Dipti M Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D Guzmán-Arocho, Adam V Jones, Miranda Pring, W Glenn McCluggage (19 February, 2024) Monika Vyas,
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
⭐ MACROSCOPIC PATHOLOGY⭐ If you haven't read our March 2024 issue on Macroscopic Pathology https://t.co/gMEt7GAOde, here's another opportunity. Two-day seminar organized by Dr. Murali Varma. And it's free! Register now! @MuraliV72899596 https://t.co/9owEjglUGE
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Mashup Score: 26Journal of Clinical Pathology: 77 (3) - 21 day(s) ago
(12 December, 2023) Jeremy Adler, Khaled Algashaamy, Monica T Garcia de Buitrago, Andre Pinto, Elizabeth Anne Montgomery (24 November, 2023) Alexander T Kikuchi, Naoki Akanuma, Won-Tak Choi, Ryan M Gill, Sanjay Kakar (20 December, 2023) Neil A Shepherd (22 November, 2023) Free Murali Varma, Laura C Collins, Runjan Chetty, Dipti M Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D Guzmán-Arocho, Adam V Jones, Miranda Pring, W Glenn McCluggage (19 February, 2024) Monika Vyas,
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
⭐ MACROSCOPIC PATHOLOGY⭐ If you haven't read our March 2024 issue on Macroscopic Pathology https://t.co/gMEt7GAOde, here's another opportunity. Two-day seminar organized by Dr. Murali Varma. And it's free! Register now! @MuraliV72899596 https://t.co/9owEjglUGE
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Mashup Score: 26Journal of Clinical Pathology: 77 (3) - 21 day(s) ago
(12 December, 2023) Jeremy Adler, Khaled Algashaamy, Monica T Garcia de Buitrago, Andre Pinto, Elizabeth Anne Montgomery (24 November, 2023) Alexander T Kikuchi, Naoki Akanuma, Won-Tak Choi, Ryan M Gill, Sanjay Kakar (20 December, 2023) Neil A Shepherd (22 November, 2023) Free Murali Varma, Laura C Collins, Runjan Chetty, Dipti M Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D Guzmán-Arocho, Adam V Jones, Miranda Pring, W Glenn McCluggage (19 February, 2024) Monika Vyas,
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
⭐ MACROSCOPIC PATHOLOGY⭐ If you haven't read our March 2024 issue on Macroscopic Pathology https://t.co/gMEt7GAOde, here's another opportunity. Two-day seminar organized by Dr. Murali Varma. And it's free! Register now! @MuraliV72899596 https://t.co/9owEjglUGE
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Mashup Score: 8Sinonasal alveolar rhabdomyosarcoma with PAX3::NCOA1 fusion expressing SOX10 and with nodal metastases: a double diagnostic pitfall - 22 day(s) ago
A 57-year-old man presented with prominent lymph nodes in the neck. Cross-sectional imaging demonstrated enlarged cervical lymph nodes, a unilateral nasal cavity tumour with extension into the ethmoid and maxillary sinuses, and widespread bone metastases. A biopsy of the nasal cavity tumour showed a poorly differentiated basaloid malignancy arranged in islands and strands (figure 1). A broad immunohistochemistry (IHC) panel was performed which demonstrated variable expression of SOX10 (figure 2) together with the expression of p16, CD56 and focally synaptophysin. The Ki67 labelling index approached 100%. No expression of AE1/AE3, CK5/6, CK7, CK20, 34βE12, p63, TTF-1, CD99, S100 or chromogranin was identified. INI-1 expression was retained. The poorly differentiated morphology and SOX10 expression led to an initial diagnosis of metastatic malignant melanoma by the head and neck pathology team. Additional IHC done after the sample was seen by the soft tissue pathologist confirmed express
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
https://t.co/X3JWWDwHDT Sinonasal alveolar rhabdomyosarcoma with its unique PAX3::NCOA1 fusion and SOX10 expression. https://t.co/6UgZBceq3o
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Mashup Score: 26Journal of Clinical Pathology: 77 (3) - 22 day(s) ago
(12 December, 2023) Jeremy Adler, Khaled Algashaamy, Monica T Garcia de Buitrago, Andre Pinto, Elizabeth Anne Montgomery (24 November, 2023) Alexander T Kikuchi, Naoki Akanuma, Won-Tak Choi, Ryan M Gill, Sanjay Kakar (20 December, 2023) Neil A Shepherd (22 November, 2023) Free Murali Varma, Laura C Collins, Runjan Chetty, Dipti M Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D Guzmán-Arocho, Adam V Jones, Miranda Pring, W Glenn McCluggage (19 February, 2024) Monika Vyas,
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
⭐ MACROSCOPIC PATHOLOGY⭐ If you haven't read our March 2024 issue on Macroscopic Pathology https://t.co/gMEt7GAOde, here's another opportunity. Two-day seminar organized by Dr. Murali Varma. And it's free! Register now! @MuraliV72899596 https://t.co/9owEjglUGE
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Mashup Score: 26Journal of Clinical Pathology: 77 (3) - 22 day(s) ago
(12 December, 2023) Jeremy Adler, Khaled Algashaamy, Monica T Garcia de Buitrago, Andre Pinto, Elizabeth Anne Montgomery (24 November, 2023) Alexander T Kikuchi, Naoki Akanuma, Won-Tak Choi, Ryan M Gill, Sanjay Kakar (20 December, 2023) Neil A Shepherd (22 November, 2023) Free Murali Varma, Laura C Collins, Runjan Chetty, Dipti M Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D Guzmán-Arocho, Adam V Jones, Miranda Pring, W Glenn McCluggage (19 February, 2024) Monika Vyas,
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
⭐ MACROSCOPIC PATHOLOGY⭐ If you haven't read our March 2024 issue on Macroscopic Pathology https://t.co/gMEt7GAOde, here's another opportunity. Two-day seminar organized by Dr. Murali Varma. And it's free! Register now! @MuraliV72899596 https://t.co/9owEjglUGE
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Mashup Score: 0Macroscopy under the microscope - 24 day(s) ago
Macroscopy is a critical aspect of histopathology reporting that has generally received less attention than microscopy and is not uncommonly delegated to less experienced practitioners with limited…
Source: baup.org.ukCategories: General Medicine News, General Journals & SocietTweet-
Dont miss out on this free 2 day webinar on issues around #macroscopic specimen examination. The webinar is based on a special issue published in March this year (2024;77:169-203). Sign up before 16 October! Full details can be found here: https://t.co/Si6w2bwsyO https://t.co/05Afr3J4MP
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Mashup Score: 36EWSR1: the promiscuous king of mesenchymal neoplasia - 27 day(s) ago
EWSR1 is the most commonly rearranged gene in mesenchymal neoplasia, and its myriad chimeric oncoproteins drive widely disparate neoplasms. Here, we survey selected EWSR1 rearrangements, including well-described EWSR1 fusions with CREB family members, ATF1 and CREB1 , as well as fusions in emerging entities such as mesenchymal neoplasms with EWSR1::PATZ1 and EWSR1::NFATC2 fusions. We also discuss recent data demonstrating the imperfect specificity of EWSR1::WT1 and, possibly, EWSR1::FLI1 fusions.
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
Here’s a brilliant review about EWSR1 from the experts Emily Towery and David Papke. All you wanted to know about this promiscuous gene and were afraid to ask.https://t.co/8dKl2Wv3y4 https://t.co/OJbRd44bF5
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➡️ Comprehensive characterization of acinar cystic transformation of the pancreas ➡️ Female (65%), mean size 4.8 cm, unifocal (71%) and multiloculate (61%) ➡️ Acinar epithelium, sometimes with duct areas ➡️ IHC acinar markers POS, mutations KRAS, SMO https://t.co/QnLNGGQEz3 https://t.co/qJcJSnW7Ck