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Mashup Score: 9Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma - 4 day(s) ago
Objective Fat mass and obesity-associated protein (FTO), an eraser of N 6-methyadenosine (m6A), plays oncogenic roles in various cancers. However, its role in hepatocellular carcinoma (HCC) is unclear. Furthermore, small extracellular vesicles (sEVs, or exosomes) are critical mediators of tumourigenesis and metastasis, but the relationship between FTO-mediated m6A modification and sEVs in HCC is unknown. Design The functions and mechanisms of FTO and glycoprotein non-metastatic melanoma protein B (GPNMB) in HCC progression were investigated in vitro and in vivo. Neutralising antibody of syndecan-4 (SDC4) was used to assess the significance of sEV-GPNMB. FTO inhibitor CS2 was used to examine the effects on anti-PD-1 and sorafenib treatment. Results FTO expression was upregulated in patient HCC tumours. Functionally, FTO promoted HCC cell proliferation, migration and invasion in vitro, and tumour growth and metastasis in vivo. FTO knockdown enhanced the activation and recruitment of tumo
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 6
Background Colonic motility in constipation can be assessed non-invasively using MRI. Objective To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response. Design Part 1: 44 healthy volunteers (HVs), 43 patients with irritable bowel syndrome with constipation (IBS-C) and 37 with functional constipation (FC) completed stool diaries and questionnaires and underwent oral macrogol (500–1000 mL) challenge. Whole gut transit time (WGTT), segmental colonic volumes (CV), MRI-derived Motility Index and chyme movement by ‘tagging’ were assessed using MRI and time to defecation after macrogol recorded. Left colonic HRCM was recorded before and after a 700 kcal meal. Patients then proceeded to Part 2: a randomised cross-over study of 10-days bisacodyl 10 mg daily versus hyoscine 20 mg three times per day, assessing daily pain and constipation. Results Part 1: Total CVs median (range) were significantly greater in IBS-C (776 (595–1033)) and FC (802 (633–951)) vs
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImage from the paper by Wilkinson-Smith et al entitled "Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study" via https://t.co/r5WqfqFftC @lwiklendt… https://t.co/PfdRv1DrhC https://t.co/HAq5xtg2ay
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Mashup Score: 13
Gastric cancer (GC) is one of the most common malignancies and a prominent cause of cancer mortality worldwide. A distinctive characteristic of GC is its intimate association with commensal microbial community. Although Helicobacter pylori is widely recognised as an inciting factor of the onset of gastric carcinogenesis, increasing evidence has indicated the substantial involvement of microbes that reside in the gastric mucosa during disease progression. In particular, dysregulation in gastric microbiota could play pivotal roles throughout the whole carcinogenic processes, from the development of precancerous lesions to gastric malignancy. Here, current understanding of the gastric microbiota in GC development is summarised. Potential translational and clinical implications of using gastric microbes for GC diagnosis, prognosis and therapeutics are also evaluated, with further discussion on conceptual haziness and limitations at present. Finally, we highlight that modulating microbes is
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImage from the #RecentAdvancesInBasicScience paper by Zeng et al entitled "Stomach microbiota in gastric cancer development and clinical implications" via https://t.co/uloknU0Kfc #GastricCancer #Microbiota https://t.co/YjQQIc0MGj
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Mashup Score: 4
Background and aim Randomised trials show improved polyp detection with computer-aided detection (CADe), mostly of small lesions. However, operator and selection bias may affect CADe’s true benefit. Clinical outcomes of increased detection have not yet been fully elucidated. Methods In this multicentre trial, CADe combining convolutional and recurrent neural networks was used for polyp detection. Blinded endoscopists were monitored in real time by a second observer with CADe access. CADe detections prompted reinspection. Adenoma detection rates (ADR) and polyp detection rates were measured prestudy and poststudy. Histological assessments were done by independent histopathologists. The primary outcome compared polyp detection between endoscopists and CADe. Results In 946 patients (51.9% male, mean age 64), a total of 2141 polyps were identified, including 989 adenomas. CADe was not superior to human polyp detection (sensitivity 94.6% vs 96.0%) but outperformed them when restricted to ad
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImage from the paper by Sinonquel et al entitled "Clinical consequences of computer-aided colorectal polyp detection" via https://t.co/6NSu0qbn8J @dominiekdewulf @NastazjaPilonis #Endoscopy #Polyps https://t.co/lXXbUzItYr
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Mashup Score: 24
To cite: Singal AG, Narasimman M, Daher D, et al. Effectiveness of mailed outreach and patient navigation to promote HCC screening process completion: a mult…
Source: www.youtube.comCategories: General Medicine News, GastroenterologyTweet-
New #GUTVideo by @docamitgs @ruben_hernaez on the paper "Effectiveness of mailed outreach and patient navigation to promote HCC screening process completion: a multicentre pragmatic randomised clinical trial" via https://t.co/vkLy8cmGWJ Paper: https://t.co/eAzHwx2fWn… https://t.co/lqXqeWHB6H https://t.co/6cS60WBHFB
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Mashup Score: 1Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production - 5 day(s) ago
Objective Puerarin (PU) is a natural compound that exhibits limited oral bioavailability but has shown promise in the treatment of atherosclerosis (AS). However, the precise mechanisms underlying its therapeutic effects remain incompletely understood. This study aimed to investigate the effects of PU and its mechanisms in mitigating AS in both mice and humans. Design The impact of PU on AS was examined in ApoE −/− mice fed a high-fat diet (HFD) and in human patients with carotid artery plaque. To explore the causal link between PU-associated gut microbiota and AS, faecal microbiota transplantation (FMT) and mono-colonisation of mice with Prevotella copri ( P. copri ) were employed. Results PU alleviated AS by modulating the gut microbiota, as evidenced by alterations in gut microbiota composition and the amelioration of AS following FMT from PU-treated mice into ApoE−/− mice fed HFD. Specifically, PU reduced the abundance of P. copri , which exacerbated AS by producing trimethylamine (
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImage from the paper by Li et al entitled "Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production" via https://t.co/57gZt5etSd #Microbiome https://t.co/RkYBTc5FVP
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Mashup Score: 3Is mailed outreach and patient navigation a perfect solution to improve HCC screening? - 5 day(s) ago
Hepatocellular carcinoma (HCC) is a significant global health problem, and its incidence is expected to exceed 1 million new HCC annually by 2025.1 The reported 3-year survival rate for advanced-stage HCC is less than 17%, while 70% of patients diagnosed with early-stage HCC can achieve 5-year survival.2 Despite well-established guidelines and the clear benefits of early detection, the meta-analysis results (29 papers, 1 18 799 patients) showed that only 24% of individuals at risk for developing HCC were screened.3 Efforts to surmount barriers at patient, provider and healthcare levels have shown a minimal screening rate increase over time.3 4 One of the reasons for the disappointing results might be the fact that authors focused on individual barriers, rather than considering the screening failure the result of the interplay of different factors. Additionally, the published studies have the following limitations, detailed reasons for screening failure are missing, the majority of the
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImage from the #GUTCommentary by Dr Iuliana Pompilia Radu on "Is mailed outreach and patient navigation a perfect solution to improve HCC screening?" via https://t.co/vQ5bP0f8N7 #HCC https://t.co/JOJL0GoKRc
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Mashup Score: 5
We read with interest the letter from Han et al about our study1 and we thank those authors for underlining points to be discussed about the real place of single use and reusable endoscope strategies. Although the benefits for reducing cross-infections seem significant, assessing the positive indirect environmental impact is difficult, as the number of patients involved in high-infection risk2 care remains very low compared with the daily endoscopy practice evaluated in this study, with conventional gastroscopes, disinfected in the standard way, in a routine activity and not in intensive care units with high-level disinfection processes.3 Moreover, this study focused on gastroscopes, with low risk of cross-infections in opposition to duodenoscopes. Of course, the weight of the endoscope’s plastic is an important element in the analysis, explaining the difference between our results and those …
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTLetter by @MathieuPioche15 et al on "Single-use scopes may reduce various environmental impacts of gastroscopy in some situations but probably not in routine practice of endoscopy units" via https://t.co/sj2mvEDx5a #GreenEndoscopy https://t.co/3XN8glwDZG
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Mashup Score: 1Gut: 73 (12) - 5 day(s) ago
(17 August, 2024) Mohamed G Shiha, Annalisa Schiepatti, Stiliano Maimaris, NIcoletta Nandi, Hugo A Penny, David S Sanders (9 August, 2024) Jonathan P Jacobs, Elizabeth A Spencer, Drew S Helmus, Julianne C Yang, Venu Lagishetty, Gerold Bongers, Graham Britton, Kyle Gettler, Pamela Reyes-Mercedes, Jianzhong Hu, Amy Hart, Esi Lamousé-Smith, Jan Wehkamp, Carol Landers, Philip Debbas, Joana Torres, Jean-Frederic Colombel, Judy Cho, Inga Peter, Jeremiah Faith, Jonathan Braun, Marla Dubinsky (12 August, 2024)
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
Spectacular high angle night view of Tianjin Eye Ferris wheel in Tianjin, China. Read in this issue the elegant work of Zhou et al showing how Vilanterol plus the STING agonist boosted the efficacy of CLDN18.2 BiTEs against pancreatic cancer via https://t.co/dgtUd9Mp7K #GUTCover… https://t.co/HVaGofGZMB https://t.co/4SIGKYep9S
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Mashup Score: 3Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma - 5 day(s) ago
Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood. Objective We aimed to identify ICB resistance-associated druggable histone deacetylases (HDACs) and develop a readily translatable combination approach for patients with hepatocellular carcinoma (HCC). Design We correlated the prognostic outcomes of HCC patients from a pembrolizumab trial ([NCT03419481][1]) with tumourous cell expressions of all HDAC isoforms by single-cell RNA sequencing. We investigated the therapeutic efficacy and mechanism of action of selective HDAC inhibition in 4 ICB-resistant orthotopic and spontaneous models using immune profiling, single-cell multiomics and chromatin immunoprecipitation-sequencing and verified by genetic modulations and co-culture systems. Results HCC patients showing higher HDAC1 / 2 / 3 expressions
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
Read the #GUTOnline paper by Tu and Wu et al entitled "Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma" via https://t.co/5jXqtBvVgA @stephaniema912 @caroltong92 #HCC https://t.co/MtyQ78V7sj
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#GUTAbstract by Chen et al on the paper entitled "Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma" via https://t.co/9dP3SOotia @HKUniversity #HCC https://t.co/SLdjUKtVf9