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Mashup Score: 2Hypertriglyceridemia and its impact on mitotane monitoring in adrenocortical carcinoma - 4 month(s) ago
Summary Mitotane is used for treatment of advanced adrenocortical carcinoma. It is administered when the carcinoma is unresectable, metastasized, or at high-risk of recurrence after resection. In addition, mitotane is considered to have direct adrenolytic effects. Because of its narrow therapeutic–toxic range, therapeutic drug monitoring (TDM) is warranted. In 2020, a left-sided adrenal gland tumor was found (5.8 cm) in a 38-year-old man. Considering the size of this lesion and inability to exclude an adrenocortical carcinoma on imaging, a laparoscopic adrenalectomy was performed. Histopathologic examination determined presence of an adrenocortical carcinoma (pT2N0M0 ENSAT stadium II; ki67 10–15%). There was no evidence for residual or metastatic disease but given the high risk of recurrence, adjuvant therapy with mitotane was initiated. During TDM, a sudden and spuriously high level of mitotane was observed but without signs or symptoms of toxicity. After exploration, it was found tha
Source: edm.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0Diagnostic pitfalls in a young adult with new diabetes - 4 month(s) ago
Summary A 20-year-old South Asian male presented with polyuria, polydipsia, HbA1c 81 mmol/mol, BMI 28.8 and family history of both type 1 and type 2 diabetes mellitus. As autoantibody testing was negative and c-peptide level demonstrated significant endogenous insulin secretion, type 1 diabetes was excluded. Given his age and family history, the differential diagnosis included maturity-onset diabetes of the young (MODY), a rare form of diabetes caused by a single-gene variant. A high probability of MODY was calculated and he was subsequently referred for genetic testing. Although a useful tool, the pre-test probability calculator for MODY is only validated in White Europeans. A heterogenous variant of unknown clinical significance of the NEUROD1 gene was detected, leading to gliclazide use with poor response. The patient responded well to metformin. Type 2 diabetes was considered the most likely diagnosis. This case highlights the diagnostic challenges in young patients of Asian ethnic
Source: edm.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Read this insightful case report by Natalie Below et al. @GGH_Site @UofGlasgow, 'Diagnostic pitfalls in a young adult with new #diabetes' ➡️ https://t.co/nSyiuFfEVB https://t.co/kptjhwCW7y
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Mashup Score: 0
Summary A 60-year-old woman presented to our clinic with an acute onset 3 months history of right ankle pain. The patient had a history of poorly differentiated thyroid cancer, which was treated with total thyroidectomy, left lateral neck dissection levels II–V and central neck dissection levels VI–VII followed by postoperative I-131 radioactive iodine (131I) ablation therapy 3.7 GBq 6 months ago. The post-131I WBS showed residual iodine-avid thyroid tissue with no other iodine-avid disease or metastasis. SPECT/CT of the neck and chest showed nonavid bilateral pulmonary nodules, discrete nodal masses in mediastinum and nonavid bone lesions. FDG-PET CT scan showed FDG-avid mediastinal lymph nodes (LN), innumerable non-FDG-avid subcentimetric pulmonary nodules and few FDG-avid lytic lesions in the skeleton. X-ray and MRI of the right ankle showed a well-marginated lytic lesion in the posterior body of calcaneus and 5 × 6 cm soft tissue mass lesion, respectively. The histopathology of the
Source: edm.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Omayma Elshafie et al. present the first reported case of poorly differentiated #thyroid #carcinoma #metastasis to the #calcaneus. Read it here ➡️ https://t.co/2aHsMrFzgT https://t.co/t6KBXmgqIG
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Mashup Score: 0Now recruiting for the role of Senior Editor! - 5 month(s) ago
EDM Case Reports is currently recruiting for the role of Senior Editor to join its distinguished Editorial Board for a three-year term and help shape the future of the journal. Responsibilities and benefits As Senior Editor, you will be responsible for overseeing the peer review of 1–2 case reports submitted to the journal per month. Alongside scientific quality, you will assess manuscripts…
Source: edm.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
We are currently recruiting for the role of Senior Editor to join our distinguished Editorial Board for a three-year term, and help shape the future of the journal. Learn more 👉 https://t.co/NUy80x3ArL https://t.co/Xft7WHxTi4
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Mashup Score: 3Alerts - 5 month(s) ago
To create a content alert please click “Create Account” and follow the steps to create a free account. Add alerts by going to the current volume page and selecting your alert of choice. Citation alerts, which are generated when articles are cited online, can be set up on the individual article. You can then sign in to the ‘My stuff’ area, to modify your alerts, see your…
Source: edm.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
📩 Receive the latest clinical #endocrine case reports straight to your inbox! Sign up here ➡️ https://t.co/TWvX7q2Hce @Soc_Endo @EndoSocAus @ESEndocrinology @BritSPED @UKINETS @AUDiabetesSoc @CSEM_SCEM @isendo https://t.co/Bdxfqda5yz
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Mashup Score: 0Reasons to publish - 6 month(s) ago
Key reasons for authors to choose EDM Case Reports to publish their articles with
Source: edm.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Do you have a case report featuring unusual symptoms, novel treatment or key findings that shed a new light on the possible pathogenesis of a disease? Submit your case report to #Endocrinology, #Diabetes and #Metabolism Case Reports 👉 https://t.co/3L16ATbwLj https://t.co/TVDyQzU2tK
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Mashup Score: 1Clinical and molecular description of two cases of neonatal diabetes secondary to mutations in PDX1 - 6 month(s) ago
Summary Pancreatic dysgenesis (PD) is a rare congenital disease, with less than 100 cases reported in the literature. In most cases, patients are asymptomatic and the diagnosis is made incidentally. In this report, we present the case of two brothers with a history of intrauterine growth retardation, low birth weight, hyperglycemia, and poor weight gain. The diagnosis of PD and neonatal diabetes mellitus was made by an interdisciplinary team composed of an endocrinologist, a gastroenterologist, and a geneticist. Once the diagnosis was made, treatment with an insulin pump, pancreatic enzyme replacement therapy, and supplementation with fat-soluble vitamins was decided. The use of the insulin infusion pump facilitated the outpatient treatment of both patients. Learning points Pancreatic dysgenesis is a relatively rare congenital anomaly; most of the time, patients are asymptomatic and are diagnosed incidentally. The diagnosis of pancreatic dysgenesis and neonatal diabetes mellitus should
Source: edm.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Read this case report by Nicolas Forero-Castro et al. @HOMILCOL describing the first two cases in Colombia of #pancreatic #dysgenesis, a rare congenital disease, secondary to a compound heterozygous mutation in the PDX1 gene ➡️ https://t.co/C8Jpr2NX1e https://t.co/H0qxxDkart
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Mashup Score: 2Severe Cushing’s syndrome from an ectopic adrenocorticotropic hormone-secreting neuroendocrine tumour treated by osilodrostat - 7 month(s) ago
Summary Severe Cushing’s syndrome from an ectopic adrenocorticotropic hormone-producing tumour is rare but often demands rapid diagnostics and treatment of hypercortisolism with its comorbidities. Pharmacotherapy of hypercortisolism by ketoconazole, metyrapone and osilodrostat is currently available. If unsuccessful or insufficient a bilateral adrenalectomy is an option. We present a 28-year-old female with severe Cushing’s syndrome caused by a bronchial metastatic neuroendocrine tumour (NET). Hypercortisolism was efficiently treated by osilodrostat with block–replace and then titration regimen. A once-daily dose was finally used with normalised cortisol levels. Androgen levels measured by liquid chromatography–mass spectrometry were slightly elevated during the treatment but without any symptoms. A simple once-daily use of osilodrostat with titration regimen led to normalised cortisol levels in a severe Cushing’s syndrome patient with an uncurable bronchial NET. Transient hypocortisol
Source: edm.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Václav Hána Jr et al. @CharlesUniPRG present a case of a 28-year-old female with severe #Cushing’s syndrome caused by a bronchial metastatic #neuroendocrine #tumour. Learn their key learning points ➡️ https://t.co/jAs4LHVS05 https://t.co/6kJ9TIEgS3
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Mashup Score: 0Browse | EDM Case Reports - 9 month(s) ago
Browse | EDM Case Reports
Source: edm.bioscientifica.comCategories: Endocrinology, Latest HeadlinesTweet-
Explore clinical case reports on common and rare conditions in all areas of clinical #endocrinology, #diabetes and #metabolism - all fully open access and free to read. 🔍 Use the refine tool on our website to find reports related to your specialism: https://t.co/soxF7OlDsA https://t.co/rDB20RSm6v
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Mashup Score: 0Antithyroid arthritis syndrome caused by methimazole in a patient with Graves’ disease - 9 month(s) ago
Summary This is a report on antithyroid arthritis syndrome (AAS) which is a rare adverse effect of antithyroid agents. AAS presents with severe symptoms including myalgia, arthralgia, arthritis, fever, and skin eruption due to the use of antithyroid agents. We encountered a 55-year-old woman with severe pain in the hand and forearm and arthralgia in multiple joints, including the knee, ankle, hand, and wrist on day 23 after initiation of methimazole (MMI) for Graves’ disease. Blood tests revealed elevated inflammation markers such as C-reactive protein and interleukin-6, and magnetic resonance imaging of the hands confirmed inflammation findings. After withdrawing MMI on day 25, symptoms showed a tendency toward improvement. Afterwards, inflammation markers also dropped to an almost normal range. In addition to the above findings, the absence of anti-neutrophil cytoplasmic antibodies and most vasculitis symptoms such as nephritis, skin, or pulmonary lesions led to the diagnosis of AAS.
Source: edm.bioscientifica.comCategories: Endocrinology, Latest HeadlinesTweet-
Discover this recent Case Report by Muneo Kawasumi et al. demonstrating the importance of awareness regarding #antithyroid #arthritis #syndrome, which is a rare and under-recognized, but life-threatening adverse effect of antithyroid agents ➡️ https://t.co/vFznxzPYs0 https://t.co/txDR9ZB15h
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"I was very interested in this case report illustrating that #hypertriglyceridaemia can lead to spuriously high #mitotane levels. This is especially relevant as mitotane can also alter the lipid profile." Read Dr Marie Freel's Case Report of the month ➡️ https://t.co/DBEiNu6j1n https://t.co/JXLKczC5iv