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Mashup Score: 1Impact of Neoadjuvant Concurrent Chemoradiation (NACCRT) on Operability and Survival in Locally Advanced Inoperable Breast Cancer - 6 month(s) ago
Inoperable locally advanced breast cancers (LABC) are treated with neoadjuvant chemotherapy (NACT). We studied the use of neoadjuvant concurrent chemoradiation (NACCRT) in patients with inoperable LABC.
Source: www.redjournal.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 4Adolescent and Young Adult Germ Cell Tumors: Epidemiology, Genomics, Treatment, and Survivorship - 6 month(s) ago
Innovations in the care of adolescent and young adult (AYA) germ cell tumors (GCTs) are needed for one of the most common AYA cancers for which treatment has not significantly changed for several decades. Testicular GCTs (TGCTs) are the most common cancers in 15- to 39-year-old men, and ovarian GCTs (OvGCTs) are the leading gynecologic malignancies in women younger than 25 years. Excellent outcomes, even in widely metastatic disease using cisplatin-based chemotherapy, can be achieved since Einhorn and Donohue’s landmark 1977 study in TGCT. However, as the severity of accompanying late effects (ototoxicity, neurotoxicity, cardiovascular disease, second malignant neoplasms, nephrotoxicity, and others) has emerged, efforts to deintensity treatment and find alternatives to cisplatin have taken on new urgency. Current innovations include the collaborative design of clinical trials that accrue GCTs across all ages and both sexes, including adolescents (previously on pediatric trials), and Ov
Source: ascopubs.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 2EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome – Update 2023 - 6 month(s) ago
On behalf of the EORTC Cutaneous Lymphoma Tumours Group (EORTC-CLTG) and following up on earlier versions published in 2006 and 2017 this document provides an updated standard for the treatment of mycosis fungoides and Sézary syndrome (MF/SS). It considers recent relevant publications and treatment options introduced into clinical practice after 2017.Consensus was established among the authors through a series of consecutive consultations in writing and a round of discussion. Treatment options are assigned to each disease stage and, whenever possible and clinically useful, separated into first- and second line options annotated with levels of evidence.
Source: www.ejcancer.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 2Soft Tissue Sarcomas in Adolescents and Young Adults - 6 month(s) ago
Soft tissue sarcomas (STS) represent a heterogeneous group of extraskeletal mesenchymal tumors that affect individuals throughout the entire age continuum. Despite this pervasive influence, key differences exist in the presentation of these sarcomas across varying age groups that have prevented a more uniform approach to management. Notably, rhabdomyosarcoma (RMS) is more common in children, while most nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) subtypes are more prevalent in adults. Older patients with NRSTS appear to have more molecularly complex biology and often present with more advanced disease compared with children. Poorer outcome disparities are observed in older patients with RMS despite receiving similar treatment as younger patients. In this review, we highlight differences in epidemiology, biology, and management paradigms for pediatric and adult patients with STS and explore opportunities for a unified approach to enhance the care and outcomes within the AYA populatio
Source: ascopubs.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 1Partial Breast Irradiation for Patients With Early-Stage Invasive Breast Cancer or Ductal Carcinoma In Situ: An ASTRO Clinical Practice Guideline - 6 month(s) ago
: This guideline provides evidence-based recommendations on appropriate indications and techniques for partial breast irradiation (PBI) for patients with early-stage invasive breast cancer and ductal carcinoma in situ.
Source: www.practicalradonc.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 6
PURPOSE CNS progression or relapse is an uncommon but devastating complication of aggressive B-cell lymphoma. There is no consensus regarding the optimal approach to CNS prophylaxis. This study was designed to determine whether high-dose methotrexate (HD-MTX) is effective at preventing CNS progression in patients at high risk of this complication. PATIENTS AND METHODS Patients age 18-80 years with aggressive B-cell lymphoma and high risk of CNS progression, treated with curative-intent anti–CD20-based chemoimmunotherapy, were included in this international, retrospective, observational study. Cause-specific hazard ratios (HRs) and cumulative risks of CNS progression were calculated according to use of HD-MTX, with time to CNS progression calculated from diagnosis for all patients (all-pts) and from completion of frontline systemic lymphoma induction therapy, for patients in complete response at completion of chemoimmunotherapy (CR-pts). RESULTS Two thousand four hundred eighteen all-pt
Source: ascopubs.orgCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 1
This cohort study evaluates whether adjuvant stereotactic radiosurgery delivered within a median of 14 days after resection of brain metastases is associated with improved local failure without a concomitant increase in posttreatment adverse radiation effects.
Source: jamanetwork.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 12Patient Information: Cervical Cancer Screening - 7 month(s) ago
This JAMA Patient Page discusses screening for cervical cancer, including who should be screened, recommendations for handling positive results, and the prevention of cervical cancer.
Source: jamanetwork.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 10Red Blood Cell Transfusion—AABB Guidelines - 7 month(s) ago
Red blood cell transfusion threshold guidelines from the AABB transfusion medicine association have been updated to incorporate an expanded evidence base and to introduce guidance specific to children.
Source: jamanetwork.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 2Sentinel Lymph Node Biopsy vs No Axillary Procedure in Small Node-Negative Breast Cancer - 7 month(s) ago
This randomized clinical trial assesses whether the omission of sentinel node biopsy is noninferior to sentinel lymph node biopsy in female patients with small breast cancer and negative results on preoperative ultrasonography of axillary lymph nodes.
Source: jamanetwork.comCategories: Hematologists1, Latest HeadlinesTweet
Neoadjuvant concurrent chemoradiation improves operability and survival in patients with inoperable LABC https://t.co/3qjQAN4At6