Background Atrial fibrillation (AF) is a major risk factor for ischemic stroke, and early AF diagnosis may reduce associated morbidity and mortality. A 10-variable predictive model (UNAFIED) was previously developed to estimate patients’ 2-year AF risk. This study evaluated a clinical workflow incorporating UNAFIED for screening, education, and follow-up evaluation of patients visiting a cardiology clinic who may be at an elevated risk of developing AF within 2 years. Methods Patients were included if they were aged ≥ 40 years with a scheduled in-person visit at the Eskenazi Health Cardiology Clinic between October 25, 2021, and August 10, 2022. Clinical decision support identified patients with an elevated AF risk. Initial screening with 1-lead electrocardiogram devices was offered, and routine clinical practice for diagnosis and management was followed. Physicians were surveyed on their use of the workflow, attitudes toward implementation, and perceived impact on patient care. Result