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Mashup Score: 4The trajectory of prognostication and risk stratification for patients with myelodysplastic syndromes - 9 month(s) ago
Risk stratification and prognostication are crucial for the appropriate management of patients with myelodysplastic syndromes or myelodysplastic neoplasms (MDS)
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Moving away from chemotherapy in newly diagnosed Philadelphia chromosome‐positive B‐cell acute lymphoblastic leukaemia - 10 month(s) ago
An official journal of the British Society for Haematology, the British Journal of Haematology offers high visibility for clinical, basic and translational research.
Source: onlinelibrary.wiley.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @FadiHaddad_MD: 📢 Moving away from chemotherapy in Ph-positive #ALL out in BJH @kouriehr @MDAndersonNews ➡️ https://t.co/vtVKXTSMKV
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Mashup Score: 3
ClinVar archives and aggregates information about relationships among variation and human health.
Source: www.ncbi.nlm.nih.govCategories: Hem/Oncs, Latest HeadlinesTweet-
@nihardesai7 @Prasshmehta @NicoGagelmann @Satyayadav__ @Dr_AmerZeidan @tomam04 @AbbasiMuqtadir @BijoyTelivala @BipinSavani @hidrhere @vishvdeepkhush @ReetuJain19 Likely germline given heterozygous VAF and clinvar characterization, but ideally verify with germline sampling (nails/skin) + at least sequencing for it in the related donor: https://t.co/DbxbpWmG19
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Mashup Score: 2Venetoclax Combined With FLAG-IDA Induction and Consolidation in Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia - PubMed - 2 year(s) ago
Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin + venetoclax represents an effective intensive treatment regimen in ND-AML and R/R-AML patients, associated with deep remissions and a high rate of transition to successful transplantation.
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
@nihardesai7 @Prasshmehta @NicoGagelmann @Satyayadav__ @Dr_AmerZeidan @tomam04 @AbbasiMuqtadir @BijoyTelivala @BipinSavani @hidrhere @vishvdeepkhush @ReetuJain19 Might want to consider a salvage regimen of FLAG-IDA + VEN or CLIA + VEN (fludarabine shortage): https://t.co/yZxT1N8XAn
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Mashup Score: 8
The adult-onset inflammatory disease termed VEXAS (vacuoles, E1 ubiquitin activating enzyme, X-linked, autoinflammatory, and somatic) syndrome is caused by muta
Source: American Society of HematologyCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @BloodJournal: Translation of cytoplasmic UBA1 contributes to #VEXAS syndrome pathogenesis https://t.co/r6QUqv18uE https://t.co/8NvHtzxC…
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Mashup Score: 1Treatment-free remission after ceasing venetoclax-based therapy in patients with acute myeloid leukemia - 2 year(s) ago
Key Points. A subset of patients receiving ≥12 months of VEN-based therapy can experience durable treatment-free remission (TFR) after ceasing therapyThe risk o
Source: American Society of HematologyCategories: Hem/Oncs, Latest HeadlinesTweet-
8/8 Bottom line - there is a HIGHLY selective subset of patients with AML on longterm VEN-based therapy that can experience durable TFR @MDAndersonNews @DanPollyea https://t.co/vkUhc53St5 https://t.co/KZc9tBZvZh
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Mashup Score: 5Access the recording - 2 year(s) ago
References Abelson, S., Collord, G., Ng, S. W., Weissbrod, O., Mendelson Cohen, N., Niemeyer, E., … & Shlush, L. I. (2018). Prediction of acute myeloid…
Source: Blood AcademyCategories: Hem/Oncs, Latest HeadlinesTweet-
Had fun presenting this Webinar for @blood_academy "Clonal h(a)ematopoiesis in clinical practice: the good, the bad and the ugly." You may need to become a Blood Academy member to view (it's free!). @MDAndersonNews @sanamloghavi @doctorpemm https://t.co/ncygmkJ84j https://t.co/SzCnahoEMm
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Mashup Score: 1What Clonal Hematopoiesis Can Teach Us About MDS - PubMed - 2 year(s) ago
Clonal hematopoiesis (CH), defined as the clonal expansion of mutated hematopoietic stem and progenitor cells (HSPCs), is a common aging process. CH is a risk factor for the development of hematologic malignancies, most commonly myeloid neoplasms (MNs) including acute myeloid leukemia (AML), myelody …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @HSC_papers: What Clonal Hematopoiesis Can Teach Us About MDS https://t.co/pbn1DXCU0Y https://t.co/t9pVw7E9nj
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Mashup Score: 2Activity of decitabine as maintenance therapy in core binding factor acute myeloid leukemia - PubMed - 2 year(s) ago
DAC is an effective maintenance therapy for CBF-AML patients with persistent fusion transcript at a low level after FLAG-based regimen. Attainment of CMR with DAC maintenance can lead to long-term remission in patients who have persistent MRD positive after FLAG-based regimen or are unable to receiv …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
@AaronGoodman33 Would treat akin to de novo CBF AML upfront but be ready to switch to less intense consolidation strategy if induction/early consolidation has complications: https://t.co/3rhYkNl2lq
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Mashup Score: 2
Key Points. Among patients with MDS and AML, the presence of TP53 mutation in the context of CK identifies a homogeneously aggressive diseaseTP53 mutation (in p
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Implications for clinical trial eligibility irrespective of blast count? TP53 mutation defines a unique subgroup within complex karyotype de novo and therapy-related MDS/AML | Blood Advances | American Society of Hematology https://t.co/Avi2WzkF3V
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New favourite word, abeyance, learned from reading this gem of a review article by MDS giants @AmyDeZern and Peter Greenberg: https://t.co/FVW43SpuxJ