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Mashup Score: 0
To prevent the development of endocrine-resistant breast cancer, additional targeted therapies are increasingly being trialled in combination with endocrine therapy. The molecular mechanisms facilitating cancer cell survival during endocrine treatment remain unknown but could help direct selection of additional targeted therapies. We present a novel proteomic timecourse dataset, profiling…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Overcoming biophysical barriers with innovative therapeutic delivery approaches - Cancer Gene Therapy - 2 year(s) ago
Cancer is often conceptualized as principally a cellular process, one initiated by genetic mutations in a progenitor cell that result in dysregulated cell proliferation. Accordingly, investigations into mechanisms of treatment resistance to cancer therapies often revolve around the biologic barriers to the therapies. However, there is a growing appreciation for the unique biomechanical properties…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Regulation of tumor metabolism by post translational modifications on metabolic enzymes - Cancer Gene Therapy - 2 year(s) ago
Metabolic reprogramming is a hallmark of cancer development, progression, and metastasis. Several metabolic pathways such as glycolysis, tricarboxylic acid (TCA) cycle, lipid metabolism, and glutamine catabolism are frequently altered to support cancer growth. Importantly, the activity of the rate-limiting metabolic enzymes in these pathways are specifically modulated in cancer cells. This is…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Silencing of the Apoptosis associated Tyrosine Kinase gene (AATK) has been described in cancer. In our study, we specifically investigated the epigenetic inactivation of AATK in pancreatic adenocarcinoma, lower grade glioma, lung, breast, head, and neck cancer. The resulting loss of AATK correlates with impaired patient survival. Inhibition of DNA methyltransferases (DNMTs) reactivated AATK in…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Cancer vaccine strategies using self-replicating RNA viral platforms - Cancer Gene Therapy - 2 year(s) ago
The development and success of RNA-based vaccines targeting SARS-CoV-2 has awakened new interest in utilizing RNA vaccines against cancer, particularly in the emerging use of self-replicating RNA (srRNA) viral vaccine platforms. These vaccines are based on different single-stranded RNA viruses, which encode RNA for target antigens in addition to replication genes that are capable of massively…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Breast cancer affects millions of women each year. Despite recent advances in targeted treatments breast cancer remains a significant threat to women’s health. In recent years the development of high-throughput sequencing technologies has advanced the field of transcriptomics shedding light on the role of non-coding RNAs (ncRNAs), including long ncRNAs (lncRNAs), in human cellular function and…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0The Cancer Community Awards 2022 Nomination Form - 2 year(s) ago
Nominate a deserving individual or organization making a difference for people living with or affected by cancer for a Cancer Community Award.
Source: YOUR CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Registration - 3 year(s) ago
Join us for the first webinar in a new series that will bring together international experts to discuss ongoing developments in cancer research. This first webinar will focus on emerging therapeutics, with speakers covering areas including immunotherapy, metabolic targets, and the treatment of lung and colorectal cancers. Our panellists will discuss these developments, their ongoing…
Source: register.gotowebinar.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Nature Research Awards for Inspiring Women in Science
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Cancer Gene Therapy - 3 year(s) ago
Cancer Gene Therapy is the essential gene and cellular therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest …
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
Another great quality research paper out now in CGT! https://t.co/2tnywUGTuU