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Mashup Score: 1Molecular Therapy Family of Journals | Cell Press - 1 day(s) ago
Gene and cell therapies have seen a massive transformation over the past decade from promising experimental treatments to approved medicines for a wide range of patients with genetic or acquired diseases. The Molecular Therapy family of journals is seeking submissions of original research papers for a special issue on clinical gene and cell therapy, to be published early 2025. Deadline for submission to any of our journals is September 16, 2024. To pics of interest include clinical trial results, patient
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Mashup Score: 1Call for papers: Device - 1 day(s) ago
Device special issue on soft robotics systems for advanced actuation and locomotion
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Mashup Score: 13
Juvenile idiopathic arthritis is the most common rheumatic disease in pediatrics, with multiple genetic risk factors. In this study, we utilized shared genomic segments analysis on whole-genome sequencing of 40 cases from 12 multi-generational pedigrees significantly enriched for JIA. This approach revealed risk haplotypes within the MHC and beyond.
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Mashup Score: 6Best of Molecular Cell Tech 2023 - 1 day(s) ago
Best of Molecular Cell Tech 2023
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Mashup Score: 7
While once regarded as ATP factories, mitochondria have taken the spotlight as important regulators of cellular homeostasis. The past two decades have witnessed an intensifying interest in the study of mitochondria in cells of the immune system, with many new and unexpected roles for mitochondria emerging. Immune cells offer intriguing insights as mitochondria appear to play different roles at different stages of T cell development, matching the changing functions of the cells. Here we briefly review the multifaceted roles of mitochondria during T cell differentiation, focusing on CD8+ cytotoxic T lymphocytes (CTLs) and we consider how mitochondrial dysfunction can contribute to CTL exhaustion.
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Mashup Score: 10
Cell Symposia: Engineering development and disease in organoids
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Just 4 days until the abstract submission deadline for @CellSymposia #CSOrganoids2024. Join the program alongside Keynotes Magdalena Zernicka-Goetz @MZG_Lab @ZernickaGoetz @Caltech @Cambridge_Uni & James Wells @JimWellsLab @CincyChildrens. Deadline May 10. https://t.co/A1Eed7Try1 https://t.co/JD8t6sAEGT
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Mashup Score: 165
The electron transport chain (ETC) couples electron transfer with proton pumping to generate ATP and it also regulates particular innate and adaptive immune cell function. While NLRP3 inflammasome activation was initially linked to reactive oxygen species (ROS) produced from Complexes I and III, recent research suggests that an intact ETC fueling ATP is needed. Complex II may be responsible for Th1 cell proliferation and in some cases, effector cytokine production. Complex III is required for regulatory T (Treg) cell function, while oxidative phosphorylation (OXPHOS) and Complexes I, IV, and V sustain proliferation and antibody production in B lymphocytes, with OXPHOS also being required for B regulatory (Breg) cell function. Despite challenges, the ETC shows therapeutic targeting potential for immune-related diseases and in immuno-oncology.
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Mashup Score: 3
A nucleolus (see Glossary) is formed in the vicinity of the chromosomal locus whose tandemly repeated 35-48S rDNA is transcribed (Figure 1) [1,2]. 35-48S rRNA genes encode 18S, 5.8S, and 25-28S rRNA molecules, which constitute essential components of ribosomes and which are vital for the viability of the cell. In many allopolyploids and interspecific hybrids, nucleoli are formed through the transcription and processing of 35-48S rRNA genes from one of two or more evolutionary ancestors. This phenomenon of selective repression, called Nucleolar dominance (ND), is a manifestation of subgenome dominance in these organisms (Figure 1) [3–10] and was observed in the representatives of both plant and animal subkingdoms [1].
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Mashup Score: 21On developmental programming of the immune system - 2 day(s) ago
Early-life environmental exposures play a significant role in shaping long-lasting immune phenotypes and disease susceptibility. Nevertheless, comprehensive understanding of the developmental programming of immunity is limited. We propose that the vertebrate immune system contains durable programmable components established through early environmental interactions and maintained in a stable and homeostatic manner. Some immune components, such as immunological memory, are intrinsically programmable. Others are influenced by conditions during critical developmental windows in early life, including microbiota, hormones, metabolites, and environmental stress, which impact programming. Developmental immune programming can promote adaptation to an anticipated future environment. However, mismatches between predicted and actual environments can result in disease. This is relevant because understanding programming mechanisms can offer insights into the origin of inflammatory diseases, ideally
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Mashup Score: 11Genome-wide classification of epigenetic activity reveals regions of enriched heritability in immune-related traits - 2 day(s) ago
EpiNN is a method that uses epigenetic data to detect genomic regions that are relevant for immune-system function. Regions detected using EpiNN have a high concentration of variants associated with immune-related heritable traits, such as autoimmune diseases. The effects of the associations in these regions tend to vary across populations.
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The Molecular Therapy family of journals (@moltherapy) is seeking submissions for a special issue on clinical gene and cell therapy by September 16, 2024. Learn more and submit: https://t.co/IulZVLew6m @ASGCTherapy https://t.co/w7R50jrNti