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Mashup Score: 9
Main Findings: Engineering oncogene-containing extrachromosomal DNA generates preclinical immunocompetent mouse models of cancer.Concept: Cre-mediated recombination of a region flanked by loxP sites of the same orientation enable circularization and subsequent amplification under selection.Impact: This study advances preclinical modeling of human cancer that will inform the understanding of focal amplification–driven tumorigenesis.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 3
Major Finding: Fasting-mimicking diet plus chemotherapy exhibits high response rates in triple-negative breast cancer.Concept: Tumors of complete responders exhibit an early downregulation of glucose metabolism genes and pathways. Impact: Early downregulation of glycolysis may be a predictive biomarker of response to fasting-mimicking diets.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 8
Major Finding: Cancer cells transfer mitophagy-resistant mitochondria to tumor-infiltrating lymphocytes (TIL) that impair antitumor activity. Concept: Deubiquitinase USP30 protects cancer cell-derived mitochondria from ROS-induced mitophagy in TILs.Impact: Inhibiting mitochondrial transfer may improve responses to immune checkpoint inhibitors in certain cancers.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 5
Main Findings: Assessing selection for biallelic loss of tumor suppressor genes (TSG) reveals TSG zygosity as an important feature of cancer etiology.Approach: An allele-specific analysis of somatic TSG alterations was performed on tumors of 67 cancer types from over 48,000 patients.Impact: This study sheds light on mechanisms of TSG inactivation and proposes TSG zygosity as a predictive biomarker of response.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 18
Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes.Concept: Ongoing chromothripsis in osteosarcoma contributes to rapid subclonal evolution and heterogeneity.Impact: This study proposes a prominent mechanism of chromothripsis that furthers the understanding of osteosarcoma tumor evolution.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 3
Main Findings: Complete blood count indices are patient-specific and stable over decades in healthy adults.Concept: These hematologic setpoints are deep physiological phenotypes associated with variation in clinical risk.Impact: A deeper understanding of patient-specific setpoints may inform the management of many common conditions, including myeloproliferative neoplasms.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 24Combined KRAS Inhibition and Immune Therapy Generates Durable Complete Responses in an Autochthonous PDAC Model - 17 day(s) ago
KRAS inhibition synergizes with an immunotherapy comprising of a CXCR1/2 inhibitor, an antagonistic anti-LAG3, and an agonistic anti-41BB to elicit durable, complete regressions of autochthonous tumors in the iKPC PDAC model.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 5Trial for AI Diagnosis of Breast Cancer Will Enroll 700,000 - 17 day(s) ago
The UK’s National Health Service will enroll nearly 700,000 women in a trial to study how artificial intelligence (AI) tools can aid in the diagnosis of breast cancer. In the EDITH trial, supported by £11 million (about $13.8 million) from the UK’s National Institute for Health Care and Research, women ages 50 to 71 will be screened every 3 years at one of 30 sites across the UK. Five distinct AI platforms will be used to analyze and diagnose about two thirds of the mammograms, which will be compared to the remaining one third of scans to be analyzed by two specialists, the current standard for mammograms in the UK. A recent study involving more than 460,000 women found that radiologists identified nearly 18% more breast tumors on mammograms when using AI assistance (Cancer Discov 2025 Feb 4 [Epub]), but no studies have yet investigated how AI fares in diagnosing breast cancer on its own…
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 9
Main Findings: Visugromab, a GDF-15 blocking antibody, is tolerable and elicits clinical responses in combination with nivolumab.Concept: GDF-15 may represent a mechanism of anti-PD-1 resistance that can be targeted to enhance antitumor immunity.Impact: This phase I/IIa trial supports the safety and further clinical evaluation of this combination, particularly in NSCLC and urothelial cancer.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0RFK Jr. Nomination Advances to Senate Floor - 18 day(s) ago
The Senate Finance Committee voted today in favor of Robert F. Kennedy (RFK) Jr.’s nomination for Secretary of the Department of Health and Human Services, setting up a Senate floor vote. While the 13 Democrats on the committee voted no, all the committee’s 14 Republicans voted to advance the nomination, including Bill Cassidy, MD (R-La.), a physician who implored RFK Jr. during last week’s hearing––to no avail––to reject theories that vaccines cause autism and said he was “struggling” with the nomination. Cassidy today wrote on X that “with the serious commitments I’ve received from the administration and the opportunity to make progress on the issues we agree on like healthy foods and a pro-American agenda, I will vote yes.” The full Senate is expected to vote within the next week.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
ICYMI: "Engineered Focal Oncogene Amplifications Drive Transformation and Progression" https://t.co/TXNmtqp11t A #ResearchWatch summary of a study by @prade90, @minsizhang, @ruirui_gao, @melissyao, @aventura71, and colleagues @MSKCancerCenter @GSKGradSchool #ecDNA https://t.co/uSMrTIZBKJ