Aging-dependent differential gene expression (by Yan et al via Cancer Cell)The likelihood of developing breast cancer increases considerably for older individuals, but the biological basis for this heightened risk remains unclear. Yan and colleagues conducted an extensive single-cell multi-omic analysis to identify molecular factors associated with age-related changes in rat breast tissue. They observed notable upregulation of a growth factor called midkine in older animals, showing that midkine induced aging-associated changes in gene expression and increased proliferation in mammary epithelial cells. Treatment with midkine also promoted tumor formation in a rat breast cancer model. Similar patterns of age-related midkine expression were observed in human blood and breast tissue, and elevated levels of this protein were predictive of both higher cancer risk and poorer prognosis in younger women, highlighting midkine’s potential utility as a clinical biomarker or even a target for prev

Abstract. In October 2023, Nigeria integrated the single-dose human papillomavirus (HPV) vaccine into its routine immunization program, aiming to protect 7.7 million girls aged 9 to 14 years. This milestone in the fight against HPV-related cancers, especially cervical cancer, faces significant challenges due to high vaccine rejection rates driven by misinformation and cultural barriers. Despite the vaccine’s proven safety and efficacy, uptake remains low. This communication highlights the urgent need for a comprehensive public health education campaign to address these barriers. Proposed strategies include leveraging digital health technologies, integrating HPV education into school curricula, training community health workers, engaging religious and cultural leaders, and launching media campaigns featuring personal narratives. Implementing these evidence-based interventions is crucial for dispelling myths, misconceptions, and skepticism surrounding HPV vaccines. This will enhance acce

Abstract. Currently, eight million people in the United States suffer from cancer and it is a major global health concern. Early detection and interventions are urgently needed for all cancers, including colorectal cancer. Colorectal cancer is the third most common type of cancer worldwide. Based on the diagnostic efforts to general awareness and lifestyle choices, it is understandable why colorectal cancer is so prevalent today. There is a notable lack of awareness concerning the impact of this cancer and its connection to lifestyle elements, as well as people sometimes mistaking symptoms for a different gastrointestinal condition. Artificial intelligence (AI) may assist in the early detection of all cancers, including colorectal cancer. The usage of AI has exponentially grown in healthcare through extensive research, and since clinical implementation, it has succeeded in improving patient lifestyles, modernizing diagnostic processes, and innovating current treatment strategies. Numer

Circulating concentrations of multiple oxysterols measured at the time of an initial colorectal adenoma diagnosis may be risk factors for subsequent incidence of these lesions. Novel colorectal cancer prevention strategies may target oxysterol formation.

Developed to facilitate a better understanding across the prevention field of needed near-term next steps and long-term future directions to fully realize