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Mashup Score: 0Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade - British Journal of Cancer - 2 year(s) ago
Metastasis formation is the main cause of cancer-related death in patients with solid tumours. At the beginning of this process, cancer cells escape from the primary tumour to the blood circulation where they become circulating tumour cells (CTCs). Only a small subgroup of CTCs will survive during the harsh journey in the blood and colonise distant sites. The in-depth analysis of these…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Patients with metastatic bladder cancer have very poor prognosis and predictive biomarkers are urgently needed for early clinical detection and intervention. In this study, we evaluate the effect and mechanism of Suprabasin (SBSN) on bladder cancer metastasis. A tissue array was used to detect SBSN expression by immunohistochemistry. A tumour-bearing mouse model was used for metastasis evaluation…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling Read for free using #SharedIt: https://t.co/XPXGjrxLUo #Bladdercancer #Oncogenes https://t.co/ct0v4HHVy6
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Mashup Score: 3
Whole-genome sequencing (WGS) of cancers is becoming an accepted component of oncological care, and NHS England is currently rolling out WGS for all children with cancer. This approach was piloted during the 100,000 genomes (100 K) project. Here we share the experience of the East of England Genomic Medicine Centre (East-GMC), reporting the feasibility and clinical utility of centralised WGS for…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer Read for free: https://t.co/Re0eCHNCfN #Cancergenomics https://t.co/epbrBSthqo
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Mashup Score: 2Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer - British Journal of Cancer - 2 year(s) ago
Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell co-localisation and T cell densities. We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer Read for free: https://t.co/EeJbfKt9N7 #Cancermicroenvironment #Colorectalcancer #Tumourimmunology https://t.co/WgR7CId4OI
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Mashup Score: 1Non-muscle-invasive micropapillary bladder cancer has a distinct lncRNA profile associated with unfavorable prognosis - 2 year(s) ago
Molecular subtyping of bladder cancer has revealed luminal tumors generally have a more favourable prognosis. However, some aggressive forms of variant histology, including micropapillary, are often classified luminal. In previous work, we found long non-coding RNA (lncRNA) expression profiles could identify a subgroup of luminal bladder tumors with less aggressive biology and better outcomes. In…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Non-muscle-invasive micropapillary bladder cancer has a distinct lncRNA profile associated with unfavorable prognosis Read for free using #SharedIt: https://t.co/9RsWmHr5kj #Bladdercancer #Diagnosticmarkers https://t.co/t5pMzWK2MO
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Mashup Score: 0Sodium accumulation in breast cancer predicts malignancy and treatment response - British Journal of Cancer - 2 year(s) ago
Breast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (23Na) MRI in preclinical models of breast cancer. Female Rag2−/− Il2rg−/− and Balb/c mice bearing orthotopic breast tumours (MDA-MB-231, EMT6 and 4T1) underwent MRI as part of a randomised,…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Sodium accumulation in breast cancer predicts malignancy and treatment response Read for free: https://t.co/Hbfd1clm5b #Breastcancer #Cancerimaging https://t.co/9zuU5uLAsg
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Mashup Score: 1
The naturally occurring amino acid 5-aminolevulinic acid (5-ALA) is a precursor of protoporphyrin IX (PpIX) biosynthesised in the mitochondria. When accumulated PpIX is excited by light (wavelength of 625–635 nm), reactive oxygen species (ROS) are generated. Here, we investigated whether 5-ALA may increase the sensitisation of prostate cancer (PCA) cells to radiotherapy through the generation of…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
5-Aminolevulinic acid overcomes hypoxia-induced radiation resistance by enhancing mitochondrial reactive oxygen species production in prostate cancer cells Read for free: https://t.co/9qfDt34WhK #Prostatecancer #Radiotherapy https://t.co/3Zw3TJXC54
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Mashup Score: 1Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer - 2 year(s) ago
Small cell lung cancer (SCLC) is an aggressive malignancy with no established biomarkers. Schlafen 11(SLFN11), a DNA/RNA helicase that sensitises cancer cells to DNA-damaging agents, has emerged as a promising predictive biomarker for several drug classes including platinum and PARP inhibitors. Detection of SLFN11 in circulating tumour cells (CTCs) may provide a valuable alternative to tissue…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer Read for free using #SharedIt: https://t.co/0Gbz8SxgIW #Predictivemarkers #Smallcelllungcancer https://t.co/OxnH9q6dCe
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Mashup Score: 0Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth - 2 year(s) ago
Ferroptosis has attracted increasing interest in cancer therapy. Emerging evidences suggest that naturally occurring naphthoquinones exhibit potent anti-glioma effects via various mechanisms. The anti-glioma effects of plumbagin were evaluated by in vitro and in vivo experiments. Anti-glioma mechanism of plumbagin was studied by proteomics, flow cytometry, MDA assay, western blot, and RT-PCR….
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth Read for free using #SharedIt: https://t.co/HIkJDQWdpY #Cancertherapy #Drugscreening https://t.co/b157dNgKVK
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Mashup Score: 1RANKL regulates testicular cancer growth and Denosumab treatment has suppressive effects on GCNIS and advanced seminoma - 2 year(s) ago
Testicular germ cell tumours (TGCTs) have a high sensitivity to chemotherapy and a high cure rate, although with serious adverse effects. In the search for tumour suppressive drugs, the RANKL inhibitor Denosumab, used to treat osteoporosis, came up as a candidate since RANKL signalling was recently identified in the testis. Expression of RANKL, RANK and OPG, and the effects of RANKL inhibition…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
RANKL regulates testicular cancer growth and Denosumab treatment has suppressive effects on GCNIS and advanced seminoma Read for free using #SharedIt: https://t.co/9sxYWW9LO5 #Celldeath #Molecularmedicine #Preclinicalresearch #Testicularcancer https://t.co/chJwmHKbjT
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Functional analysis of circulating tumour cells: the KEY to understand the biology of the metastatic cascade Read for free: https://t.co/bN9JTwx28Q #Cancerstemcells #Metastasis https://t.co/0IsGIjSxXo