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Mashup Score: 2The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation - 4 month(s) ago
The Polymerase Associated Factor 1 complex (PAF1c) functions at the interface of epigenetics and gene transcription. The PAF1c is required for MLL fus…
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells - Nature - 4 month(s) ago
A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
@ZHAOJiawei9 @liamcato @UmaArora16 @erik_bao @Armstrong_dfci @seyvos @Michael_A_Erb @jyoti_nangalia Our prior studies (https://t.co/TahKdpO0hq) had suggested a model whereby variation in blood stem cell self-renewal might alter the risk for developing blood cancers, such as myeloproliferative neoplasms or MPNs. Could something similar be happening here? (7/n) https://t.co/LWfcNndfhm
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Mashup Score: 312
Rare inherited CTR9 loss-of-function variants predispose to myeloid malignancies by altering the balance between the PAF1 and super elongation complexes. Specific subunits of the PAF1 complex then act in concert with the super elongation complex to promote transcription elongation of genes that can drive the self-renewal of hematopoietic stem cells.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 22023 round-up of human genetics - 4 month(s) ago
A brief look at the most exciting stories of 2023
Source: www.gwasstories.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 12President Biden Intends to Appoint Dr. W. Kimryn Rathmell as Director of the National Cancer Institute | The White House - 6 month(s) ago
Today, President Joe Biden announced his intent to appoint Dr. W. Kimryn Rathmell as the 17th Director of the National Cancer Institute (NCI), the federal government’s principal agency for cancer research and training and the largest funder of cancer research in the world. Dr. W. Kimryn Rathmell is an accomplished physician-scientist and internationally recognized cancer expert…
Source: www.whitehouse.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 12President Biden Intends to Appoint Dr. W. Kimryn Rathmell as Director of the National Cancer Institute | The White House - 6 month(s) ago
Today, President Joe Biden announced his intent to appoint Dr. W. Kimryn Rathmell as the 17th Director of the National Cancer Institute (NCI), the federal government’s principal agency for cancer research and training and the largest funder of cancer research in the world. Dr. W. Kimryn Rathmell is an accomplished physician-scientist and internationally recognized cancer expert…
Source: www.whitehouse.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 12President Biden Intends to Appoint Dr. W. Kimryn Rathmell as Director of the National Cancer Institute | The White House - 6 month(s) ago
Today, President Joe Biden announced his intent to appoint Dr. W. Kimryn Rathmell as the 17th Director of the National Cancer Institute (NCI), the federal government’s principal agency for cancer research and training and the largest funder of cancer research in the world. Dr. W. Kimryn Rathmell is an accomplished physician-scientist and internationally recognized cancer expert…
Source: www.whitehouse.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 12President Biden Intends to Appoint Dr. W. Kimryn Rathmell as Director of the National Cancer Institute | The White House - 6 month(s) ago
Today, President Joe Biden announced his intent to appoint Dr. W. Kimryn Rathmell as the 17th Director of the National Cancer Institute (NCI), the federal government’s principal agency for cancer research and training and the largest funder of cancer research in the world. Dr. W. Kimryn Rathmell is an accomplished physician-scientist and internationally recognized cancer expert…
Source: www.whitehouse.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 860Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A - 6 month(s) ago
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the β-thalassemia syndromes. Genetic association studies have identified sequence variants in the gene BCL11A that …
Source: www.science.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 123Monica Bertagnolli, M.D., takes the helm at NIH - 6 month(s) ago
Monica M. Bertagnolli, M.D., started today as the 17th director of the National Institutes of Health, the nation’s biomedical research agency and largest public funder of biomedical research in the
Source: www.nih.govCategories: General Medicine News, Hematologists1Tweet
@ZHAOJiawei9 @liamcato @UmaArora16 @erik_bao @Armstrong_dfci @seyvos @Michael_A_Erb @jyoti_nangalia But this was confusing, given that prior work (https://t.co/q45XtuJ9Tn) from Muntean and others had suggested that the PAF1 complex was necessary for blood stem cell function. (9/n) https://t.co/OwMu3IW9jS