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Mashup Score: 0Mauricio Ambriz (@mauambriz) • Instagram photos and videos - 6 day(s) ago
8,971 Followers, 823 Following, 40 Posts – See Instagram photos and videos from Mauricio Ambriz (@mauambriz)
Source: www.instagram.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 299
Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed of proteoglycans, glycosaminoglycans, and functional plasma proteins that are critical for antithrombogenicity, regulating tone, controlling permeability, and reducing endothelial interactions with leukocytes and platelets. Degradation of the glycocalyx in sepsis is substantial due to thromboinflammation, and treatments for sepsis and septic shock may exacerbate endotheliopathy via additional glycocalyx injury. As a result, therapeutic strategies aimed at preserving glycocalyx integrity should be considered, including modifications in fluid volume resuscitation, minimizing catecholamine use, controlling hyperglycemia, and potential use of corticosteroids and anticoagulants. In this review, we explore treatment strategies aligned with the recommendations outlined in the Surviving Sepsis C
Categories: General Medicine News, Hem/OncsTweet
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Mashup Score: 5Status Epilepticus - 9 day(s) ago
In this review, we discuss treatment and considerations for status epilepticus in general intensive care unit patients, acquired brain injury, autoimmune conditions, toxidromes, pediatrics, and pregnancy.
Source: www.criticalcare.theclinics.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 5Cushing Syndrome–A Review - 9 day(s) ago
This review summarizes current evidence regarding diagnosis and treatment of Cushing syndrome due to endogenous overproduction of cortisol.
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 421
Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by structural and functional abnormalities within the intricate network of microvessels beyond well-known and documented target organs, i.e., the retina, kidney, and peripheral nerves. Indeed, an intact microvascular bed is crucial for preserving each organ’s specific functions and achieving physiological balance to meet their respective metabolic demands. Therefore, diabetes-related microvascular dysfunction leads to widespread multiorgan consequences in still-overlooked non-traditional target organs such as the brain, the lung, the bone tissue, the skin, the arterial wall, the heart, or the musculoskeletal system. All these organs are vulnerable to the physiopathological mechanisms that cause microvascular damage in diabetes (i.e., hyperglycaemia-induced oxidative stress, inflammation, and endothelial dysfunction) and collectively contribute to abnormalities in the microvessels’ structure and function, co
Source: cardiab.biomedcentral.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 791
Nature Reviews Endocrinology – This Review highlights the latest advances in our understanding of the mechanisms of action of metformin. Potential repurposing of metformin for other indications is…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Pernicious anaemia - 17 day(s) ago
### What you need to know A 55 year old woman presents to her GP with fatigue, “pins and needles” sensation in her feet, and poor concentration. Clinical examination and routine blood investigations were unremarkable. Her symptoms gradually worsened over two years. She also developed exertional dyspnoea and unsteadiness while walking. On examination, she had pallor, resting tachycardia, and sensory neuropathy in both legs. A peripheral blood smear revealed macrocytic anaemia and hypersegmented neutrophils. Further investigations confirmed severe B12 deficiency secondary to pernicious anaemia. Pernicious anaemia is an autoimmune disorder affecting the gastric mucosa with impaired absorption of dietary cobalamin (vitamin B12) resulting in B12 deficiency. Figure 1 depicts the pathophysiology of pernicious anaemia. Vitamin B12 is essential for production of blood cells and myelination of nerves. Its deficiency causes megaloblastic anaemia. Neuronal demyelination and subsequent degeneration
Source: www.bmj.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3Pernicious anaemia - 19 day(s) ago
### What you need to know A 55 year old woman presents to her GP with fatigue, “pins and needles” sensation in her feet, and poor concentration. Clinical examination and routine blood investigations were unremarkable. Her symptoms gradually worsened over two years. She also developed exertional dyspnoea and unsteadiness while walking. On examination, she had pallor, resting tachycardia, and sensory neuropathy in both legs. A peripheral blood smear revealed macrocytic anaemia and hypersegmented neutrophils. Further investigations confirmed severe B12 deficiency secondary to pernicious anaemia. Pernicious anaemia is an autoimmune disorder affecting the gastric mucosa with impaired absorption of dietary cobalamin (vitamin B12) resulting in B12 deficiency. Figure 1 depicts the pathophysiology of pernicious anaemia. Vitamin B12 is essential for production of blood cells and myelination of nerves. Its deficiency causes megaloblastic anaemia. Neuronal demyelination and subsequent degeneration
Source: www.bmj.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Mauricio Ambriz (@mauambriz) • Instagram photos and videos - 21 day(s) ago
8,971 Followers, 823 Following, 40 Posts – See Instagram photos and videos from Mauricio Ambriz (@mauambriz)
Source: www.instagram.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 461
Cardiogenic shock (CS) is characterized by low cardiac output and sustained tissue hypoperfusion that may result in end-organ dysfunction and death. CS is associated with high short-term mortality, and its management remains challenging despite recent advances in therapeutic options. Timely diagnosis and multidisciplinary team-based management have demonstrated favourable effects on outcomes. We aimed to review evidence-based practices for managing patients with ischemic and non-ischemic CS, detailing the multi-organ supports needed in this critically ill patient population.
Categories: General Medicine News, Hem/OncsTweet
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