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Mashup Score: 1Current Issue Table of Contents: Gastroenterology - 2 month(s) ago
Login with your AGA username and password. Volume 167 Issue 4 p633-820,
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 19Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells - 2 month(s) ago
The authors use animal models, human biopsy samples, and human cells to demonstrate that MYO5B traffics the drug transporter P-glycoprotein to the apical membrane of intestinal epithelial cells.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 14Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis - 2 month(s) ago
Helicobacter pylori infection and autoimmune gastritis give rise to similar metaplastic cell phenotypes. One metaplastic subtype, common to both settings, resembles incomplete intestinal metaplasia and transcriptionally relates to gastric cancer.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 86Targeting the Interleukin 23 Pathway in Inflammatory Bowel Disease - 2 month(s) ago
Interleukin (IL) 23, a member of the IL12 family of cytokines, maintains intestinal homeostasis, but is also implicated in the pathogenesis of inflammatory bowel diseases (IBDs). IL23 is a heterodimer composed of disulfide-linked p19 and p40 subunits. Humanized monoclonal antibodies selectively targeting the p19 subunit of IL23 are poised to become prominent drugs in IBDs. In this review, we discuss the pharmacodynamic and pharmacokinetic properties of the currently available IL23p19 inhibitors and discuss the mechanistic underpinnings of their therapeutic effects, including the mechanism of action, epitope affinity, potency, and downstream signaling.
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Mashup Score: 14
Despite advances in medical therapy, approximately one-half of patients with Crohn’s disease (CD) develop complications ultimately requiring surgery. Currently, no treatment offers a chance of cure.1,2 The increasing incidence and prevalence of CD globally pose a substantial burden at the population and individual levels. Thus, a better understanding of the early triggers of CD is desperately needed to enhance early detection, improve medical therapy, and offer a possibility of interventions that prevent development of CD.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 7Gastro Journal Club: Biofeedback Treatment for Abdominal Distention - 3 month(s) ago
Description:For this installment of the Gastro Journal Club, we are honored to host Prof. Fernando Azpiroz from University Hospital Vall d’Hebron. He is join…
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Mashup Score: 22Current Issue Table of Contents: Gastroenterology - 3 month(s) ago
Login with your AGA username and password. Volume 165 Issue 2 p307-522,
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 23BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma - 3 month(s) ago
This study has discovered a potential new target for treating pancreatic cancer. By inhibiting a protein called BRD9, researchers were able to block the growth and invasiveness of cancer stem cells, as well as improve their sensitivity to chemotherapy. This finding could lead to the development of novel strategies for eliminating cancer stem cells in patients with pancreatic cancer.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet-
This study has discovered a potential new target for treating pancreatic cancer. By inhibiting a protein called BRD9, researchers were able to block the growth and invasiveness of cancer stem cells, as well as improve their sensitivity to chemotherapy ➡️ https://t.co/SXPuAPn5ff https://t.co/V8szpBwAT5
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Mashup Score: 8Management of Small Bowel Crohn’s Disease Strictures: To Cut, to Stretch, or to Treat Inflammation? - 3 month(s) ago
This patient’s case history (void of protected health information) was discussed in a multidisciplinary meeting including adult gastroenterologists (CL, BGF, FR), radiologists (MB, JGF), and a colorectal surgeon (SH) with an adult gastroenterologist (FR) serving as the moderator. We summarize the case history and discussion in this article.
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Mashup Score: 22Current Issue Table of Contents: Gastroenterology - 3 month(s) ago
Login with your AGA username and password. Volume 165 Issue 2 p307-522,
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
RT @PaulMoayyedi: The September issue of @AGA_Gastro is now online! Check it out here: https://t.co/V4lme5B7uz