Cossec et al. show that chemical inhibition of SUMOylation in mouse embryonic stem cells produces self-assembled embryo-like structures with characteristics resembling a head and a trunk. Suppression of SUMOylation, a general chromatin barrier to cell fate transitions, increases genome-wide DNA methylation, supporting the emergence of cell diversity.
Using single-nucleus RNA-seq coupled with activity-regulated genes, Guo et al. identify one galanin neuronal subtype in the preoptic area activated during recovery sleep and show cell-type-specific…
Blawski et al. show that KMT2D is methylated by the lysine methyltransferase SMYD2 at K1330. SMYD2 loss attenuates PI3K inhibitor-induced KMT2D chromatin binding at estrogen-receptor (ER)…
Rivard et al. report that a combination of density-based replisome enrichment and label-free quantitative mass spectrometry (iPOND2-DRIPPER) substantially increases both replication and repair factor yields and…
Li et al. report the maturational principles of network segregation and integration of the functional connectome during the first 1,000 days of human life. They also show…
Dhaliwal et al. used human pluripotent stem cell-derived neurons, neural precursors, and cortical organoids to show that hyperactivation of both mTORC1 and mTORC2 contributes to the…
Cuhadar et al. find that the abundance of LGI1 at the presynaptic surface controls glutamatergic transmission. Synaptic surface LGI1 increases with neuronal activity but is reduced…
Martinez-Sarmiento et al. demonstrate that, during heterokaryon reprogramming, global chromatin decondensation and loss of repressive histone modifications occur at late stages after cell fusion. Activation of…
(Cell Reports 36, 109673; September 7, 2021)
The insect gustatory receptors (Grs) are one of the largest families of ion channels in the animal kingdom. Frank et al. unveil the structure of a…
