We report an increased prevalence of genetic determinants in patients with an increased severity of the HTG phenotype when considering either rare variants disrupting TG metabolism genes or an excess accumulation of common SNPs. As well, the findings confirm that the most prevalent genetic contribut …
Correspondence from The New England Journal of Medicine — Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia
Correspondence from The New England Journal of Medicine — Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia
Lp(a)-associated DGs and LPA have a potential role in Lp(a)-induced monocyte inflammation by increasing cytokine secretion and monocyte transendothelial migration. This DG-induced inflammation is, in…
Composite biomarker factors, representative of the balance between thrombotic and thrombolytic propensity, provided an improvement in predicting stroke/TIA beyond CHA2DS2-VASc score.
Patients with chronic inflammatory disorders such as psoriasis have an increased risk of cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide…
Author links open overlay panel Sotirios Tsimikas MD a, Vera Bittner MD, MSPH b Dr Tsimikas is supported by NHLBI grants R01 HL159156 and HL170224;…
APOE genotypes strongly influence Lp(a) and apoB-related lipoprotein levels. This suggests that differences in affinity of apoE proteins for lipoprotein clearance receptors may affect Lp(a)…
