Nature Reviews Gastroenterology & Hepatology – Visceral pain is a major clinical issue, most commonly associated with gastrointestinal disorders. This Review discusses molecular mechanisms by…
Background and objectives Primary objectives: to compare the rates of sustained clinical remission at 12 months in patients treated with antitumour necrosis factor (anti-TNF) and…
npj Precision Oncology – CAR-T cell therapy for the treatment of adult high-grade gliomas
Despite significant advances in biologic and small molecule treatments and the emergence of combination therapies to treat inflammatory bowel diseases (IBD) a large unmet need…
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a wide spectrum of liver injuries, ranging from hepatic steatosis, metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis to MASLD-associated…
Immune checkpoint inhibitors (ICI) have led to breakthrough improvements in the management of malignancy including hepatocellular (HCC) and biliary tract cancer, improving decades-old standards of…
To cite: Roca Suarez AA, Plissonnier M, Grand X, et al. TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into h…
Communications Chemistry – Aroma compositions are usually complex mixtures of odor-active compounds exhibiting diverse molecular structures, and assessing or predicting the olfactory qualities of…
Giant pandas are captivating animals with worldwide interest. Their distinctive colour, furriness and slow, swaggering, lifestyle may be some of the reasons why people love…
Objective Whether and how the PI3K-AKT pathway, a central node of metabolic homeostasis, is responsible for high-fat-induced non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remain…
