de Visser and Joyce review the complex interplay between the tumor and its microenvironment throughout cancer evolution and discuss the tumor cell-intrinsic, cell-extrinsic, and systemic factors that may be exploited for rational design of anti-cancer treatments.
Brickman and colleagues show that an unsegregated ICM-like population arises spontaneously in naive ESC culture in KOSR media. These cells resemble the E3.5 ICM and…
Redford et al. demonstrate that that CD4+ and CD8+ T cells have distinct contributions for the pathogenesis of fat and lean stores wasting, respectively, during a chronic…
Consumption of certain probiotic strains may be beneficial for reducing the risk of acute upper respiratory tract infections (URTIs), however, underlying immunological mechanisms are elusive.…
In this article, Hu and colleagues show that CRISPR-Cas9-engineered human embryonic stem cells exhibit specific expression of immune inhibitory molecules, PD-L1/CTLA4Ig, within differentiated hepatocyte-like cells.…
McGee et al. develop Fragmid, a modular toolkit and online portal for the creation of CRISPR vectors compatible with many delivery approaches, enzymes, and mechanisms. They…
Interrogating data of monozygotic twins discordant for multiple sclerosis (MS), Ingelfinger et al. identify decreased frequency of blood CXCR3+ B cells as a non-inheritable feature in…
Tenggara et al. use a single-cell-derived antibody supernatant analysis (SCAN) workflow to efficiently generate quantitative BCR neutralizing IC50 data against HIV-1, on top of which a…
The Xist RNA protein complex, present only in females, is immunogenic and may underlie female-biased autoimmunity.
Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling pathways in immune cells. Notable examples include succinate and itaconate, which have pro- and…
