AMP-activated protein kinase (AMPK) dysregulation is implicated in osteoarthritis (OA), but the mechanisms underlying this dysregulation remain unclear. We investigated the role of cereblon, a substrate-recognition protein within the E3-ligase ubiquitin complex, in AMPK dysregulation and OA pathogenesis.
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Podcast Ā· EULAR Ā· Welcome to the Paediatric EULAR Podcast, where we explore various topics related to Rheumatic and Musculoskeletal Diseases (RMDs) and ongoing research.Ā Join…
Fibular strut allograft or bone cement for reconstruction after curettage of a giant cell tumour of the proximal femur
Single-stage orthoplastic treatment of complex calcaneal osteomyelitis with large soft-tissue defects
A 44-year-old morbidly obese man suffered an ultra-low velocity knee dislocation with anterior and posterior cruciate and medial collateral ligament tears after falling from a…
Welcome to the first edition of the Presidentās Corner! I am grateful to Bharat Kumar, MD, MME, FACP, FAAAAI, RhMSUS, and the editors of The…
A Spanish Collaborative Group study of Tocilizumab (TCZ) in Giant Cell Arteritis (GCA) demonstrated high efficacy regardless of the different vascular phenotypes treated.Ā Multicentre study of…
Objectives Endogenous retroelements (EREs) stimulate type 1 interferon (IFN-I) production but have not been explored as potential interferonogenic triggers in Rheumatoid Arthritis (RA). We investiga…
ing research, it remains unknown whether somatosensory changes are a cause or effect of pain or if they are driven by other potentially confounding factors.…
