Targeting inflammatory protein could help treat severe asthma
Australian scientists have revealed a promising new treatment for severe asthma, targeting a protein that controls inflammation and scarring of the airways.
Australian scientists have revealed a promising new treatment for severe asthma, targeting a protein that controls inflammation and scarring of the airways.
De Sanctis et al. examine the malignancy-associated programs regulating T cell infiltration and function in the tumor environment and find that the tetraspanin claudin 18 on the…
Classical monocytes present as a circulating and heterogenous macrophage precursor pool, but the implication for tissue macrophage biology remains elusive. Trzebanski et al. establish that the…
Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as…
With allergy season in full swing, primary care providers can expect an increase in patients presenting with rhinitis symptoms. Common symptoms include coughing, sneezing, a…
Peripheral sensory neurons recognize diverse noxious stimuli, including microbial products and allergens traditionally thought to be targets of the mammalian immune system. Activation of sensory…
Chronic obstructive pulmonary disease (COPD) is characterized by infiltration of the airways and lung parenchyma by inflammatory cells. Lung pathology results from the cumulative effect…
Pancreatic islet β cells are highly sensitive to autoinflammatory insults, in part due to their highly oxidative microenvironment. Srivastava et al. report that CXCL16 on resident…
Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination…
Microglia are brain-resident macrophages that play key roles in brain development and experience dependent plasticity. In this review we discuss recent findings regarding the molecular…
The ubiquitin-binding endoribonuclease N4BP1 is a critical immunosuppressor, but the mechanism by which it acts to constrain TLR-induced inflammatory cytokine production has remained unclear. In…