• Mashup Score: 22
    Biliary Obstruction Due to IgG4-Related Disease - 2 year(s) ago

    A man in his sixth decade of life with a history of myasthenia gravis and antiphospholipid syndrome complicated by embolic strokes presented for evaluation of progressive jaundice and pruritus. Laboratory evaluation revealed marked hyperbilirubinemia and elevated lipase. Computed tomography imaging revealed a pancreatic head masslike lesion with a peripancreatic low-attenuation rim and dilation…

    Source: Mayo Clinic Proceedings
    Categories: Hem/Oncs, Latest Headlines
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      sanamloghavi

      #WHOHEME 🧵#3 is dedicated to the ever-elusive IgG4-related disease IgG4-RD is an immune-mediated disease w/mass-forming lesions w/a lymphoplasmacytic infiltrate⬆️IgG4+ #PlasmaCells &“storiform fibrosis” typically w/ ⬆️serum IgG4 titer. Image source https://t.co/wFm0CmUX5p https://t.co/OeyifXLlxR

  • Mashup Score: 3
    Emerging therapy options for IgG4-related disease - 2 year(s) ago

    Awareness of IgG4-related disease (IgG4-RD) is increasing worldwide and specialists are now familiar with most of its clinical manifestations and mimickers. IgG4-RD promptly responds to glucocortic…

    Source: Taylor & Francis
    Categories: Hem/Oncs, Latest Headlines
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      sanamloghavi

      IgG4-related disease tends to respond to steroids. Here is a nice summary of emerging therapies. Image source https://t.co/5OqMDISXOX #WHOHEME https://t.co/RkAQvR0DoL

  • Mashup Score: 12
    Mechanisms and assessment of IgG4-related disease: lessons for the rheumatologist - Nature Reviews Rheumatology - 2 year(s) ago

    Awareness of IgG4-related disease, which shares many clinical, and potentially pathogenetic, similarities with certain rheumatic disorders, is increasing worldwide. This Review provides an overview of this disease entity, with particular focus on pathogenesis, clinical features, diagnosis and treatment, for the benefit of rheumatologists, who are increasingly likely to be involved in the…

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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    • Profile photo of AaronGoodman33
      AaronGoodman33

      To all the dedicated hematologists and pathologists trying to learn the new classification for hematologic malignancies. #WHOHEME edition #3 is out tomorrow and we tackle the exciting yet challenging IgG4-related disease! @sanamloghavi https://t.co/PgwR1RO9yu https://t.co/EDkRenVSGK

  • Mashup Score: 6
    CAP Annual Meeting Agenda - CAP Annual Meeting - 2 year(s) ago

    CAP Annual Meeting Agenda

    Source: CAP Annual Meeting
    Categories: Hem/Oncs, Latest Headlines
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    • Profile photo of sanamloghavi
      sanamloghavi

      Are you overwhelmed by the ever-growing list of large B cells lymphomas?🫤 18 different kinds R now recognized by #WHO 5th Ed. 🤯 but fear not & join us for our #CAP22 workshop in NOLA We’ve got amazing cases lined up 4 U https://t.co/fIJe3ewUxE #hemepath #PathTwitter #WHOHEME https://t.co/ttITfaUAlq

  • Mashup Score: 0
    Autoimmune pancreatitis type 1 - 2 year(s) ago

    Pancreas – Autoimmune pancreatitis type 1

    Source: www.pathologyoutlines.com
    Categories: Hematologists1, Latest Headlines
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      AaronGoodman33

      An usual cause of recurrent pancreatitis... Recurrent pancreatitis. No history of EtOG abuse. CT scan is performed A biopsy is performed which demonstrates a lymphoplasmacytic infiltrate... Diagnosis? Stay tuned to #WHOHEME with @sanamloghavi https://t.co/PNsMLqk18O https://t.co/TWMASlZu2f

  • Mashup Score: 1
    Wolters Kluwer Health - 2 year(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

    Source: lww.com
    Categories: Hem/Oncs, Latest Headlines
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      sanamloghavi

      MPDCP is most commonly associated w/ #CMML and less frequently #AML, #MDS and other #MPN… if you do IHC you will see 🔬that ~5% of AMLs and ~20% of CMML have MPDCPs Image from @AJSPjournal by @JoeKhouryMD et al https://t.co/pxPETh7d0U #hemepath #WHOHEME 2/ https://t.co/cc6KnQwEj2

  • Mashup Score: 4
    Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia - Leukemia - 2 year(s) ago

    Islands of CD123high cells have been commonly described in the bone marrow of patients with chronic myelomonocytic leukemia (CMML). Using a multiparameter flow cytometry assay, we detected an excess of CD123+ mononucleated cells that are lineage-negative, CD45+, CD11c−, CD33−, HLA-DR+, BDCA-2+, BDCA-4+ in the bone marrow of 32/159 (20%) patients. Conventional and electron microscopy, flow…

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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    • Profile photo of sanamloghavi
      sanamloghavi

      1️⃣Don’t mistake MPDCP w/ #BPDCN (your 👀+🔬= your best tool 2️⃣Mention MPDCP in your #pathology report! they have prognostic significance & associated w/ ⬇️ AML-free survival in #CMML shown by Dr. Lucas @MrinalPatnaik & Solary et al https://t.co/hZmmNLvWlF @LeukemiaJnl #WHOHEME https://t.co/o3c2fYKrfU

    • Profile photo of sanamloghavi
      sanamloghavi

      MPDCP are #Clonal pDC proliferations (neoplastic) & commonly w/ same mutations as the myeloid neoplasm they R ass. w/ (CMML: RAS pathway; AML: RUNX1) This beautiful Fig frm paper by Drs. Lucas @MrinalPatnaik ,Solary & et al. in @LeukemiaJnl https://t.co/hZmmNLvWlF #WHOHEME 3/ https://t.co/4lMENIGSlq

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