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Mashup Score: 11Fallacies of Using the Win Ratio in Cardiovascular Trials: Challenges and Solutions - 9 month(s) ago
Summary The win ratio was introduced into cardiovascular trials as a potentially better way of analyzing composite endpoints to account for the hierarchy of clinical significance of their component…
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Mashup Score: 2Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice: - 1 year(s) ago
Highlights • The LMNA protein is involved in genomic stability. • Mutations in the LMNA gene caused DCM. • DSBs are increased in DCM. • DSBs, released into the cytoplasm, are sensed by CGAS, which …
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#JACCBTS study indicates that targeting the CGAS/DDR pathway might be beneficial in the treatment of dilated cardiomyopathy caused by mutations in the LMNA gene. https://t.co/h1BLg4vkvE #cvDCM #HeartFailure #DNA #BasicScience #TranslationalScience #CardioTwitter https://t.co/1ANvk1PJml
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Mashup Score: 0Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure: - 1 year(s) ago
Highlights • The biological drivers of reverse LV remodeling are not well understood. • Transaortic constriction induced hemodynamic pressure overload superimposed on acute LAD ligation in mice res…
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What is the therapeutic relevance of enhancing autophagic flux in the heart? Find out in #JACCBTS: https://t.co/hzWzf1HmWC #HeartFailure #openaccess #BasicResearch #TranslationalScience #CardioTwitter @DLMann_MD https://t.co/zVreb67j10
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Mashup Score: 1A Novel Puncturable Atrial Septal Defect Occluder: The Results of Preclinical Experiment and First-in-Human Study - 1 year(s) ago
Highlights • In the presence of an ASD occluder, the subsequent puncture of the atrial septum for such patients may be challenging, and this important route for left-sided interventional procedures…
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First-in-human study of a puncturable atrial septal defect occluder. https://t.co/pJWPv2N26t #JACCBTS #openaccess #BasicResearch #TranslationalScience #CardioTwitter https://t.co/27sKCLQA9g
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Mashup Score: 2Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury: - 1 year(s) ago
Highlights • Neopetroside A preserved cardiac hemodynamics and mitochondrial respiration capacity ex vivo after ischemia/reperfusion injury in rat hearts. • NPS A significantly prevented cardiac fi…
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How does neopetroside A prevent cardiac fibrosis in mouse model of myocardial infarction? Find out in #JACCBTS: https://t.co/DDDhf68aLt #openaccess #BasicResearch #TranslationalScience #cvMI #CardioTwitter https://t.co/b2mxD21kow
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Mashup Score: 0LncRNA-ZFAS1 Promotes Myocardial Ischemia-Reperfusion Injury Through DNA Methylation-Mediated Notch1 Down-Regulation in Mice: - 1 year(s) ago
Highlights • The increase of ZFAS1 expression in MIRI is an important cause of cardiomyocyte apoptosis and ROS production. • ZFAS1 can directly interact with the promoter region of Notch1, recruit …
Categories: Cardiac Surgery, Latest HeadlinesTweet-
ICYMI: How does LncRNA-ZFAS1 promote myocardial ischemia reperfusion injury? Find out in #JACCBTS: https://t.co/L39qVI6iwA #IHD #openaccess #BasicResearch #TranslationalScience #CardioTwitter https://t.co/tiKpbaDiCP
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Mashup Score: 2Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype: - 1 year(s) ago
Highlights • This study shows the existence of PAI-1+ PEVs. Approximately 20% of plasma PAI-1 is composed of PAI-1+ PEVs. • Elevated PAI-1+ PEV levels were predictive of 1-year major adverse cardia…
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ICYMI: Can PAI-1+ PEV levels predict adverse cardiac events? Find out in #JACCBTS: https://t.co/GR5apM6y8l #cvCAD #openaccess #BasicResearch #TranslationalScience #CardioTwitter https://t.co/RXYepn8NVO
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Mashup Score: 0A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification: - 1 year(s) ago
Highlights • The long noncoding RNA SNHG3 was upregulated in the leaflets of both patients and mice with calcific aortic valve disease. • SNHG3 can associate with EZH2 in the nucleus of hVICs to ep…
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How does SNHG3 promote aortic valve calcification? Drs. Long Chen, Zhe Zheng, and colleagues work to answer this question in #JACCBTS: https://t.co/IAV9PzsVzn #openaccess #BasicResearch #TranslationalScience https://t.co/WbilFSpyVa
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Mashup Score: 7Translating Imaging Into 3D Printed Cardiovascular Phantoms: A Systematic Review of Applications, Technologies, and Validation - 1 year(s) ago
Highlights • 3D printed patient specific phantoms can visualize complex cardiovascular anatomy • Common imaging modalities for 3D printing are CCT and CMR • Material jetting/PolyJet and stereolitho…
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Take a deep dive into how and why generating 3D printed CV phantoms from imaging modalities help visualize complex CV anatomy and enable tailoring of therapy in this #JACCBTS State-of-the-Art Review: https://t.co/I1mhFGIljy #TranslationalScience #3DPrinting #VisualAbstract https://t.co/D6rPwKSWxa
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Mashup Score: 3Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin Activity: - 1 year(s) ago
Highlights • Myosin-based thick filament (CK-138 or M) and troponin-based thin filament (CK-030 or T) selective compounds improved cardiac muscle contraction and calcium sensitivity • T exhibited f…
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How does targeting thick vs thin cardiac filaments influence cardiac contraction? Learn more in this new issue of #JACCBTS: https://t.co/l0N3jwtPDI #CardiacMyocyte #HeartFailure #cvHCM #BasicScience #TranslationalScience #openaccess #VisualAbstract https://t.co/rj686M98Rt
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Check out this thoughtful discussion by Ajufo, et al. on the advantages and challenges of using the win ratio in cardiovascular trials: https://t.co/vFimSxnVpp #JACCBTS #TranslationalScience #TranslationalResearch #CardioTwitter @MRMehraMD @AditiNayakMD https://t.co/FpzGvTSoIf