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Mashup Score: 0Lisocabtagene maraleucel for second-line relapsed or refractory large B-cell lymphoma: patient-reported outcomes from the PILOT study - 8 month(s) ago
In the single-arm, open-label, multicenter, phase 2 PILOT study, second-line treatment with the chimeric antigen receptor (CAR) T-cell therapy lisocabtagene maraleucel (liso-cel) in patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL) for whom hematopoietic stem cell transplantation (HSCT) was not intended resulted in high response rates, durable responses, and a safety profile consistent with previous reports. Here, we analyzed changes in health-related quality of life (HRQOL) in patients who received liso-cel in PILOT. Patients received liso-cel, an autologous, CD19-directed, 4-1BB CAR T-cell product administered at equal target doses of CD8+ and CD4+ CAR+ T cells, for a total target dose of 100 × 10⁶ CAR+ T cells. HRQOL, a secondary endpoint of PILOT, was assessed as prespecified using 3 patient-reported outcome instruments (EORTC QLQ-C30; FACT-LymS; EQ-5D-5L). Evaluable datasets for the EORTC QLQ-C30, FACT-LymS, EQ-5D-5L health utility index, and EQ-5D visual ana
Source: haematologica.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 3
There are more references available in the full text version of this
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1CD19-CAR T-Cell Therapy Demonstrates Activity Against Extramedullary Disease in Pediatric Patients with B-ALL - 9 month(s) ago
Key Points. There is a high burden of extramedullary disease in pediatric patients with relapsed/refractory B-ALL prior to CD19-CAR T cell therapyCD19-CAR T cel
Source: ashpublications.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Efficacy of checkpoint inhibition after CAR-T failure in aggressive B-cell lymphomas: outcomes from 15 US institutions - 9 month(s) ago
Key Points. In this analysis, checkpoint inhibitor therapy after CAR-T failure resulted in an overall response rate of 19% and median PFS of 54 days.Patients wi
Source: ashpublications.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4Emapalumab for the treatment of Refractory Cytokine Release Syndrome in Pediatric Patients - 9 month(s) ago
Emapalumab is a monoclonal antibody targeting interferon gamma (IFN-g) and is currently FDA-approved for refractory, recurrent, or progressive hemophagocytic ly
Source: ashpublications.orgCategories: Hematologists1, Latest HeadlinesTweet-
RT @CARTTherapy: Emapalumab for the treatment of Refractory Cytokine Release Syndrome in Pediatric Patients https://t.co/CU2I3YVz5g #CART…
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Mashup Score: 1
Abstract. Patients with cancer demonstrate an increased vulnerability for infection and severe disease by SARS-CoV-2, the causative agent of COVID-19. Risk fact
Source: academic.oup.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Longitudinal Serum Proteomics Characterization of CD19-CAR-T Cell Therapy for B-Cell Malignancies - 9 month(s) ago
Chimeric antigen receptor (CAR)-modified T cells have demonstrated remarkable efficacy in treating B-cell leukemia. However, treated patients may potentially develop side effects, such as cytokine release syndrome (CRS), the mechanisms of which remain unclear. Here, we collected 43 serum samples from eight patients with B-cell acute lymphoblastic leukemia (B-ALL) before and five time points after CD19-specific CAR-T cell treatment. Using TMTpro 16-plex-based quantitative proteomics, we quantified 1151 proteins and profiled the longitudinal proteomes analysis of each patient. Seven days after therapy, we found the most dysregulated inflammatory proteins. Lipid metabolism proteins, including APOA1, decreased after therapy, reached their minimum after 7 days, and then gradually recovered. Hence, APOA1 has been selected as a potential biomarker of the CRS disease progression. Furthermore, we identified CD163 as a potential biomarker of CRS severity. These two biomarkers were successfully v
Source: pubs.acs.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Single-cell RNA analysis reveals cell-intrinsic functions of CAR-T cells correlating with response in a phase II study of lymphoma patients - 9 month(s) ago
Abstract. Purpose: Although CD19 CAR-T cell therapy has shown remarkable success in B cell malignancies, a substantial fraction of patients does not obtain a long-term clinical response. This could be influenced by the quality of the individual CAR-T infusion product. To shed some light on this, clinical outcome was correlated to characteristics of CAR-T cell infusion products. Patients and Methods: In this phase II study patients with B cell lymphoma (n=23) or leukemia (n=1) received one or two infusions of third generation CD19-directed CAR-T cells (2×108/m2). The clinical trial was registered at clinicaltrials.gov: NCT03068416. We investigated the transcriptional profile of individual third generation CD19 CAR-T infusion products using targeted single-cell RNA sequencing and multicolor flow cytometry. Results: Two CAR-T infusions were not better than one in the settings used in this study. As for the CAR-T infusion products we found that effector-like CD8+CAR-T cells with a high pol
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4
Cartesian Therapeutics and National Institute of Neurological Disorders and Stroke of the National Institutes of Health.
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Cost-effectiveness of chimeric antigen receptor T-cell therapy in adults with relapsed or refractory follicular lymphoma - 10 month(s) ago
Follicular lymphoma (FL) is traditionally considered treatable but incurable. In March 2021, the US Food and Drug Administration approved the use of c…
Source: www.sciencedirect.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
Mini-thread on patient-reported outcomes (PROs) from the phase II PILOT trial of second-line liso-cel in patients not eligible for ASCT, now published @Haematologica by Dr. @ligordon et al. #lymsm #tcellrx #celltherapy https://t.co/OWg3ZBciqH 1/ https://t.co/NyXJTeYBJt