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Mashup Score: 0Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline - 7 month(s) ago
PURPOSE To provide guidance regarding best practices in the prevention and management of medication-related osteonecrosis of the jaw (MRONJ) in patients with cancer. METHODS Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and ASCO convened a multidisciplinary Expert Panel to evaluate the evidence and formulate recommendations. Guideline development involved a systematic review of the literature and a formal consensus process. PubMed and EMBASE were searched for studies of the prevention and management of MRONJ related to bone-modifying agents (BMAs) for oncologic indications published between January 2009 and December 2017. Results from an earlier systematic review (2003 to 2008) were also included. RESULTS The systematic review identified 132 publications, only 10 of which were randomized controlled trials. Recommendations underwent two rounds of consensus voting. RECOMMENDATIONS Currently, MRONJ is defined by (1) current or p
Source: ascopubs.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Pretreatment Vitamin D Deficiency Is Associated With Impaired Progression-Free and Overall Survival in Hodgkin Lymphoma - 7 month(s) ago
PURPOSE Vitamin D deficiency is described as a modifiable risk factor for the incidence of and mortality in many common cancers; however, data in Hodgkin lymphoma (HL) are lacking. PATIENTS AND METHODS We thus performed a study measuring pretreatment vitamin D levels in prospectively treated patients with HL and correlated this with clinical outcomes. A total of 351 patients from the German Hodgkin Study Group clinical trials (HD7, HD8, and HD9) were included. RESULTS Fifty percent of patients were vitamin D deficient (< 30 nmol/L) before planned chemotherapy. Pretreatment vitamin D deficiency was more common in relapsed/refractory patients than matched relapse-free controls (median baseline vitamin D, 21.4 nmol/L v 35.5 nmol/L; proportion with vitamin D deficiency, 68% v 41%; P < .001). Vitamin D–deficient patients had impaired progression-free survival (10-year difference, 17.6%; 95% CI, 6.9% to 28.4%; hazard ratio, 2.13; 95% CI, 1.84 to 2.48; P < .001) and overall survival (10-year
Source: ascopubs.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Introduction: Chemotherapy associated osteoporosis is a severe problem in patients with malignant diseases as it increases the risk for fractures and deteriorat
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Lymphoma (NHL). We prospectively evaluated bone remodeling pre- and post-chemotherapy in 61 patients with newly diagnosed NHL. First-line chemotherapy resulted in high bone turnover, which led to increased bone loss and reduced bone mineral density (BMD) of lumbar spine (L1-L4) and femur neck (FN). The reduction of L1-L4 and FN BMD post-chemo was more profound in males and in older patients (>55 years). Patients who received 8 cycles of chemotherapy had a greater reduction of L1-L4 and FN BMD as compared to 6 cycles. The administration of chemotherapy also resulted in a dramatic increase of bone resorption markers (CTX and TRACP-5b), bone formation markers, (bALP and Osteocalcin) and of osteoblast regulator Dickkopf-1. During study period, one patient had a pathological fracture in his right FN….
Source: journals.lww.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Increased risk of osteoporosis following commonly used first-line treatments for lymphoma: a Danish Nationwide Cohort Study - 7 month(s) ago
High-dose prednisolone is used in first-line treatment for lymphoma, but the potential adverse impact on bone health is unclear. Danish patients with diffuse large B-cell lymphoma or follicular lym…
Source: www.tandfonline.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Identification of non-Hodgkin lymphoma patients at risk for treatment-related vertebral density loss and fractures - 7 month(s) ago
Osteoporosis International – Information on bone loss in treated non-Hodgkin’s lymphoma patients is limited. In this study, we used CT to analyze bone loss as well as prevalent and incident…
Source: link.springer.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Fractures are common within 18 months following first-line R-CHOP in older patients with diffuse large B-cell lymphoma - 7 month(s) ago
Key Points. Cumulative fracture incidence after R-CHOP in older patients (>70 years) is high (11.4% at 18 months).Bone involvement, prephase steroids, or eit
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
This cohort study defines the cumulative incidence of osteonecrosis of the jaw at 3 years in patients receiving zoledronic acid for metastatic bone disease from any malignant neoplasm.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0High incidence of fractures after R-CHOP-like chemotherapy for aggressive B-cell non-Hodgkin lymphomas - 7 month(s) ago
Supportive Care in Cancer – Patients with non-Hodgkin lymphoma (NHL) have a median age of 67, with 70% surviving over 5 years. Chemotherapy for aggressive NHL includes cyclophosphamide,…
Source: link.springer.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Webprogram Unavailable - 7 month(s) ago
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Source: ash.confex.comCategories: Hem/Oncs, Latest HeadlinesTweet
Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ @ASCO Clinical Practice Guideline [Jul 22, 2019] Noam Yarom et al. @JCO_ASCO https://t.co/ivWlLHEpEF #SuppOnc #mmsm #lymsm #BoneHealth