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Mashup Score: 0Novel insights into mouse models of ectopic proplatelet release - 1 year(s) ago
Key Points. ADAP-, ARP2/3-, WASp-, and PFN1-deficient MKs show reduced adhesion to collagen.β1-integrin activation and F-actin organization is impaired in ADAP-
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Key Points. Participants who undergo gene therapy for ADA-SCID may harbor underlying germline alterations that increase risk of malignancy.Participants who unde
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Enrichment of BTK Leu528Trp mutations in patients with CLL on zanubrutinib: potential for pirtobrutinib cross-resistance - 2 year(s) ago
Key Points. Patients with CLL progressing on zanubrutinib have an enrichment of the BTK Leu528Trp compared with those who progress on ibrutinib.Cross-resistance
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Role of stem cell transplant in CD30+ PTCL following frontline brentuximab vedotin plus CHP or CHOP in ECHELON-2 - 2 year(s) ago
Key Points. Consolidative SCT should be considered in patients with CD30+PTCL in a CR following frontline treatment with A+CHP.Further studies are needed to est
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1gain-of-function variant in the Wiskott-Aldrich syndrome gene is associated with a MYH9-related disease-like syndrome - 2 year(s) ago
Key Points. The gain-of-function p.I294T variant in WASp causes a disease combining neutropenia, macrothrombocytopenia, proteinuria, and renal failure.The expan
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Addition of romiplostim to conditioning prior to HSCT allows chemotherapy reduction while maintaining engraftment levels - 2 year(s) ago
Key Points. Romiplostim sensitizes HSCs to a clinically used chemotherapy-conditioning regimen.Romiplostim allows reducing busulfan dose in conditioning while m
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Key Points. COVID-19 does not exacerbate the already high risk of venous thromboembolism among hospitalized patients with sickle cell disease.
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Real-world characteristics of T-cell apheresis and clinical response to tisagenlecleucel in B-cell lymphoma - 2 year(s) ago
TO THE EDITOR:
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Improvement of hemolytic anemia with GBT1118 is renoprotective in transgenic sickle mice - 2 year(s) ago
Key Points. A reduction in hemolysis with voxelotor analog, GBT1118, reduced hemoglobinuria and kidney injury biomarkers in transgenic sickle mice.Improved chro
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3Allelic complexity of KMT2A partial tandem duplications in acute myeloid leukemia and myelodysplastic syndromes - 2 year(s) ago
Key Points. KMT2A-PTD undergo complex allelic events associated with advanced disease stage (AML over MDS), progression, and increased PTD expression.KMT2A-PTD
Source: American Society of HematologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
β1-integrin activation and F-actin organization is impaired in ADAP-, PFN1-, and ARPC2-deficient MKs. https://t.co/Dyr1Scf2Lj #stimulusreport #plateletsandthrombopoiesis https://t.co/Z8HkRHLvID