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Mashup Score: 6
The variation in the speed and intensity of SARS-CoV-2 transmission and severity of the resulting COVID-19 disease are still imperfectly understood. We postulate a dose-response relationship in COVID-19, and that “the dose of virus in the initial …
Source: PubMed Central (PMC)Categories: Hematologists1, Latest HeadlinesTweet
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Mashup Score: 1Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial - Critical Care - 2 year(s) ago
Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/Kh89E7c0Oa #AUXORA + #CORTICOSTEROIDS: A NEW STANDARD OF CARE IN SEVERE #COVID_19 #PNEUMONIA? #FOAMed #FOAMcc #BMC #ICU #lung #respiratory_failure #ARDS #cytokine #calcium_channel #immunology #Sars_CoV2 @jlvincen @ISICEM https://t.co/O7goK0hhvs
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Mashup Score: 0
Background Whether prone position (PP) improves clinical outcomes in COVID-19 pneumonia treated with noninvasive ventilation (NIV) is unknown. We evaluated the effect of early PP on 28-day NIV failure, intubation and death in noninvasively ventilated patients with moderate-to-severe acute hypoxemic respiratory failure due to COVID-19 pneumonia and explored physiological mechanisms underlying…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Does #prone position improve clinical outcomes in #COVID_19 #pneumonia treated with noninvasive #ventilation? https://t.co/E6nIMdwqt2 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #ARDS #respiratory_failure #Sars_Cov2 https://t.co/IwuRmNRMwZ
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Mashup Score: 1Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial - Critical Care - 2 year(s) ago
Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/Kh89E6UppA #AUXORA + #CORTICOSTEROIDS: A NEW STANDARD OF CARE IN SEVERE #COVID_19 #PNEUMONIA? #FOAMed #FOAMcc #BMC #ICU #lung #respiratory_failure #ARDS #cytokine #calcium_channel #immunology #Sars_CoV2 @jlvincen @ISICEM https://t.co/240VGtOybE
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Mashup Score: 0Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial - Critical Care - 2 year(s) ago
Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess EDITOR’S PICK https://t.co/Kh89E7c0Oa #AUXORA + #CORTICOSTEROIDS: A NEW STANDARD OF CARE IN SEVERE #COVID_19 #PNEUMONIA? #FOAMed #FOAMcc #BMC #ICU #lung #respiratory_failure #ARDS #cytokine #calcium_channel #immunology #Sars_CoV2 @jlvincen @ISICEM https://t.co/YKPE3eGd52
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Mashup Score: 2Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial - Critical Care - 2 year(s) ago
Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced acute respiratory distress syndrome (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs in patients with…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #COVID19: #Umbilical cord-derived #mesenchymal #stromal #cells have potentially immune-modulatory properties https://t.co/CHaiMgV4z1 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #UC_MSCs #respiratory_failure #ARDS #Sars_Cov2 https://t.co/8BYyGf4UrK
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Mashup Score: 6Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients - Critical Care - 2 year(s) ago
Purpose Corticosteroids, in particular dexamethasone, are one of the primary treatment options for critically ill COVID-19 patients. However, there are a growing number of cases that involve COVID-19-associated pulmonary aspergillosis (CAPA), and it is unclear whether dexamethasone represents a risk factor for CAPA. Our aim was to investigate a possible association of the recommended…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #COVID19: #dexamethasone is associated with a three times increase in the risk of #pulmonary #aspergillosis https://t.co/wWkM1FEBUv @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #infection #pandemics #Sars_Cov2 #CAPA #corticosteroid https://t.co/jurYZjzwc4
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Mashup Score: 1Effects of prone and lateral positioning alternate in high-flow nasal cannula patients with severe COVID-19 - Critical Care - 2 year(s) ago
Research Letter Open Access Published: 25 January 2022 Critical…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Alternating #prone and #lateral position may improve #oxygenation in severe #COVID19 patients https://t.co/TQID19b4jk @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #respiratory_failure #pandemics #Sars_Cov2 https://t.co/NM98LiVWRs
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Mashup Score: 2Persistence of live virus in critically ill patients infected with SARS-COV-2: a prospective observational study - Critical Care - 2 year(s) ago
Background Research on the duration of infectivity of ICU patients with COVID-19 has been sparse. Tests based on Reverse Transcriptase polymerase chain reaction (RT-PCR) detect both live virus and non-infectious viral RNA. We aimed to determine the duration of infectiousness based on viral culture of nasopharyngeal samples of patients with COVID-19. Methods Prospective observational study in…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess 8% of #ICU patients with #COVID19 grew live #virus at a median of 13 days post-initial positive #RT_PCR test https://t.co/QL6GPCywoC @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #coronavirus #Sars_Cov2 #Viral culture #infectivity #RNA https://t.co/Dk3IRnEYtq
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Mashup Score: 9Early, biomarker-guided steroid dosing in COVID-19 Pneumonia: a pilot randomized controlled trial - Critical Care - 2 year(s) ago
ClinicalTrials.gov identifier (NCT number): NCT03852537 , Registered February 25, 2019.
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #Corticosteroids dosing in #COVID19: does one size fit all? https://t.co/kb2a801qdc @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #coronavirus #Sars_Cov2 #PRC #trial #biomarker #pneumonia #ventilation https://t.co/rr0yd9P3XD
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The importance of the dose of #SARS_CoV2 particles for its pathogenicity has been neglected so far. Clinical observations of disease severity in super-spreading events support this view. #Masks may work by avoiding ingestion of high virus concentrations. https://t.co/xyZJV33BS9