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Mashup Score: 8Sociotechnical safeguards for genomic data privacy - 15 day(s) ago
Nature Reviews Genetics – In this Review, the authors describe technical and legal protection mechanisms for mitigating vulnerabilities in genomic data privacy. They also discuss how these…
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Mashup Score: 236Transposable elements in mammalian chromatin organization - 29 day(s) ago
Nature Reviews Genetics – This Review discusses how transposable elements contribute to mammalian genome evolution and gene regulation through their ability to both maintain and reshape 3D genome…
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Mashup Score: 30Microbiome epidemiology and association studies in human health - 1 month(s) ago
Nature Reviews Genetics – Microbiome epidemiology associates microbial community features with health outcomes, traits or exposures in human host populations. In this Review, the authors discuss…
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Mashup Score: 3Principles and methods for transferring polygenic risk scores across global populations - 2 month(s) ago
Nature Reviews Genetics – This Review summarizes the genetic and non-genetic factors that impact the transferability of polygenic risk scores (PRSs) across populations, highlighting the technical…
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Mashup Score: 191Single-cell genomics meets human genetics - Nature Reviews Genetics - 2 month(s) ago
In this Review, the authors describe the emerging field of single-cell genetics, which lies at the intersection of single-cell genomics and human genetics. They review the first single-cell expression quantitative trait loci studies, which combine single-cell information with genotype data at the population scale and thereby link genetic variation to the cellular processes underpinning key…
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Mashup Score: 4Genomic surveillance for antimicrobial resistance — a One Health perspective - Nature Reviews Genetics - 2 month(s) ago
Antimicrobial resistance (AMR) is an important public health issue that affects human, animal and environmental sectors worldwide. The authors review the role of genomics in AMR surveillance using a One Health approach, and how genomic approaches can help mitigate the spread of AMR to improve global health.
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Mashup Score: 1Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements - Nature Reviews Genetics - 2 month(s) ago
Chromothripsis, a complex genomic rearrangement of one (or a few) chromosomes, is frequently found in cancer genomes. The authors review methods to identify chromothripsis in cancer genomes and discuss its mechanisms of formation in micronuclei or chromosomal bridges as well as its consequences in cancer. They also highlight the link between chromothripsis and extrachromosomal DNA.
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Mashup Score: 11
The authors review genetic studies of sensorineural hearing impairment (SNHI) and their resulting insights into the molecular mechanisms underlying auditory system function. They also discuss preclinical studies of inner-ear gene therapy and key translational opportunities and challenges for treating monogenic forms of SNHI and associated balance disorders.
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Mashup Score: 76Spatial biology of cancer evolution - Nature Reviews Genetics - 3 month(s) ago
In this Review, the authors discuss our latest understanding of the spatial aspects of cancer evolution, including the roles of cancer subclonal structure, tissue architecture, and interactions between cancer cells and diverse cell types of the microenvironment at local and distant sites.
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Mashup Score: 182Sequencing and characterizing short tandem repeats in the human genome - Nature Reviews Genetics - 3 month(s) ago
This Review describes tools and approaches for characterizing short tandem repeats in the human genome from whole-genome sequencing data. Furthermore, the authors discuss how these recent developments have helped to better understand the effect of short tandem repeats on human health and disease.
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RT @NatureRevGenet: Sociotechnical safeguards for genomic data privacy https://t.co/k7BC5pmrnm #Review by @zhiyuwan, James W. Hazel, @genom…