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Mashup Score: 1MAPK Activation, P53 and Autophagy Inhibition Characterize the SARS-CoV-2 Spike Protein Induced Neurotoxicity - 1 year(s) ago
The SARS-CoV-2 spike protein and prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions activate the p38 mitogen activated protein kinase (MAPK) pathway, and SARS-CoV-2 spike proteins induce the p38 MAPK and c-Jun NH2-t
Source: AuthoreaCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 5Genetics in Medicine - 2 year(s) ago
How to best counsel patients with genetic prion diseaseAn epidemic of mad cow disease in the 80s and 90s made prion disease something of a household name. The fatal neurodegenerative disorder advances rapidly. Within 6 months, most patients develop a progressive dementia, as abnormally shaped prion proteins accumulate in their brains and render the tissue with a characteristic sponge-like…
Source: www.gimjournal.orgCategories: Genetics, Latest HeadlinesTweet-
#EditorsChoice: Prion diseases can be inherited and genetic counseling for family members of patients may be helpful #CreutzfeldtJakob #PrionDisease #PRNP #genetics https://t.co/8NU2oeUQ2q https://t.co/uQtgqrvfP7
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Mashup Score: 27Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice - 4 year(s) ago
The unfolded protein response (UPR) is critical for proteostasis in all tissues. However, chronic UPR activity in protein aggregation–associated neurodegenerative diseases detrimentally suppresses protein synthesis that is necessary for neuronal function and survival, as well as for cognition. Hughes et al. found that the phosphorylation of a threonine residue in the stress response kinase PERK…
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
A new biochemical study in @SciSignal reveals a safer potential treatment strategy for #PrionDisease and neurodegenerative disorders that involve the improper folding and clumping of proteins in the brain. #neuroscience https://t.co/fGZTViWceS Credit: Hughes et al. https://t.co/wVUBOu0L7x
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Mashup Score: 9Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice - 4 year(s) ago
The unfolded protein response (UPR) is critical for proteostasis in all tissues. However, chronic UPR activity in protein aggregation–associated neurodegenerative diseases detrimentally suppresses protein synthesis that is necessary for neuronal function and survival, as well as for cognition. Hughes et al. found that the phosphorylation of a threonine residue in the stress response kinase PERK…
Source: Science SignalingCategories: Future of Medicine, Latest HeadlinesTweet-
A new biochemical study in @SciSignal reveals a safer potential treatment strategy for #PrionDisease and neurodegenerative disorders that involve the improper folding and clumping of proteins in the brain. #neuroscience https://t.co/fGZTViWceS Credit: Hughes et al. https://t.co/lcU5FGbNQ1
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RT @Jane__Black: You may find this interesting @CyclingDoctor #Amyloidosis #PrionDisease https://t.co/gGOzz1UZwr