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Mashup Score: 1Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma - 11 hour(s) ago
The efficacy of mutant IDH1 inhibition in a genetically engineered mouse model of cholangiocarcinoma is mediated by stimulation of cytotoxic T-cell function and derepression of TET2 in tumor cells, which epigenetically resensitizes tumor cells to IFNγ.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2
Summary:. Isocitrate dehydrogenase 1 mutations (mIDH1) are common in cholangiocarcinoma, but their exact mechanisms in cholangiocarcinoma initiation and maintenance are unclear. In this issue of Cancer Discovery, Wu and colleagues identify immune suppression via TET2 inactivation as the primary means by which mIDH1 maintains cholangiocarcinoma survival, leading to an efficacious new combination of mIDH1 inhibitors and immune checkpoint blockade targeting regulatory T cells.See related article by Wu et al., p. 812 (9).
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma [Mar 8, 2022] @itsacurse et al. @BCD_AACR https://t.co/QFtLZn085q #PrecisionMedicine #ImmunoOnc #hpbcsm #cametab