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Mashup Score: 38Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms - 3 year(s) ago
Pernio or chilblains is characterized by erythema and swelling at acral sites (eg, toes and fingers), typically triggered by cold exposure. Clinical and histopathologic features of pernio are well described, but the pathogenesis is not entirely understood; vasospasm and a type I interferon (IFN-I) immune response are likely involved. During the coronavirus disease 2019 (COVID-19) pandemic,…
Source: Mayo Clinic ProceedingsCategories: Latest Headlines, RheumatologyTweet
#Chilblains #pernio in #covid19 ➡️#SARSCoV2 infection via cellular receptor ACE2 ➡️Affecting renin-angiotensin-aldosterone system ➡️Increase vasoconstricting, pro-inflammatory & prothrombotic angiotensin II pathway 👉🏽https://t.co/SmAPFUlp7L via @MayoProceedings #covidtoes https://t.co/QB8nptUoY0