-
Mashup Score: 1
o participants’ beliefs and feelings that might explain why fears and worries persist after a PE-grounded intervention for CLBP. Methods: We conducted a qualitative study involving semistructured interviews with participants from the active arm of a randomised controlled trial who received an individualised PE-grounded intervention for adults with CLBP. We used reflexive thematic analysis with an inductive approach. Results: Twenty participants were interviewed (9 women and 11 men, median age = 54 years, median pain duration = 4 years, 13 reporting at least 30% pain reduction on the trial primary outcome). Three themes were identified: 1) “Are you implying my pain is not real?”: a few participants believed the validity of their pain was being questioned. 2) “You don’t understand, my pain is different”: most participants considered the influence of an altered nervous system but did not exclude the possibility of having structural and biomechanical influences for the persistence of their
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 1
o participants’ beliefs and feelings that might explain why fears and worries persist after a PE-grounded intervention for CLBP. Methods: We conducted a qualitative study involving semistructured interviews with participants from the active arm of a randomised controlled trial who received an individualised PE-grounded intervention for adults with CLBP. We used reflexive thematic analysis with an inductive approach. Results: Twenty participants were interviewed (9 women and 11 men, median age = 54 years, median pain duration = 4 years, 13 reporting at least 30% pain reduction on the trial primary outcome). Three themes were identified: 1) “Are you implying my pain is not real?”: a few participants believed the validity of their pain was being questioned. 2) “You don’t understand, my pain is different”: most participants considered the influence of an altered nervous system but did not exclude the possibility of having structural and biomechanical influences for the persistence of their
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Why might fears and worries persist after a pain education–grounded multimodal intervention for chronic back pain? A qualitative study” by @rodrizzo_pain et al. https://t.co/eveKWdWYeO https://t.co/FRQPSrpJ2K
-
-
Mashup Score: 1
o participants’ beliefs and feelings that might explain why fears and worries persist after a PE-grounded intervention for CLBP. Methods: We conducted a qualitative study involving semistructured interviews with participants from the active arm of a randomised controlled trial who received an individualised PE-grounded intervention for adults with CLBP. We used reflexive thematic analysis with an inductive approach. Results: Twenty participants were interviewed (9 women and 11 men, median age = 54 years, median pain duration = 4 years, 13 reporting at least 30% pain reduction on the trial primary outcome). Three themes were identified: 1) “Are you implying my pain is not real?”: a few participants believed the validity of their pain was being questioned. 2) “You don’t understand, my pain is different”: most participants considered the influence of an altered nervous system but did not exclude the possibility of having structural and biomechanical influences for the persistence of their
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Why might fears and worries persist after a pain education–grounded multimodal intervention for chronic back pain? A qualitative study” by @rodrizzo_pain et al. https://t.co/eveKWdWYeO https://t.co/FRQPSrpJ2K
-
-
Mashup Score: 2
, how affective symptoms relate to the more obvious sensory and functional symptoms of joint diseases is not well understood. Here, we have addressed these gaps in knowledge. Methods: We used 2 preclinical models of joint pain in male mice and an array of behavioural and molecular assays to fully characterise functional deficits, mechanical hypersensitivity, affective symptoms, and nociceptive signaling in joint pain, as well as investigate their relationship. Results: Ankle joint inflammation and knee osteoarthritis induced mechanical hypersensitivity that lasted at least 3 months and that was not different between the 2 models on most days. However, the models presented with markedly different weight-bearing deficits, molecular profiles, and affective outcomes. Specifically, only the model of knee osteoarthritis was accompanied by an increase in negative affective behaviors, including early changes in circadian patterns, persistent cognitive impairments, and late development of depre
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Differences in multidimensional phenotype of 2 joint pain models link early weight-bearing deficit to late depressive-like behavior in male mice” by Hestehave et al. https://t.co/cFjTogjRSo https://t.co/H6dV9oDrHR
-
-
Mashup Score: 2
, how affective symptoms relate to the more obvious sensory and functional symptoms of joint diseases is not well understood. Here, we have addressed these gaps in knowledge. Methods: We used 2 preclinical models of joint pain in male mice and an array of behavioural and molecular assays to fully characterise functional deficits, mechanical hypersensitivity, affective symptoms, and nociceptive signaling in joint pain, as well as investigate their relationship. Results: Ankle joint inflammation and knee osteoarthritis induced mechanical hypersensitivity that lasted at least 3 months and that was not different between the 2 models on most days. However, the models presented with markedly different weight-bearing deficits, molecular profiles, and affective outcomes. Specifically, only the model of knee osteoarthritis was accompanied by an increase in negative affective behaviors, including early changes in circadian patterns, persistent cognitive impairments, and late development of depre
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Differences in multidimensional phenotype of 2 joint pain models link early weight-bearing deficit to late depressive-like behavior in male mice” by Hestehave et al. https://t.co/cFjTogjRSo https://t.co/H6dV9oDrHR
-
-
Mashup Score: 1
vestigate potential sex differences in the analgesic efficacy of pregabalin that may contribute to disparities in human outcomes. Methods: We used a mouse model of chronic widespread muscle pain (CWP) to test the effects of pregabalin on muscle hyperalgesia, nonreflexive pain, and motor behaviors. The CWP pain model combines 2 pH 4.0 saline injections, spaced 5 days apart, into the gastrocnemius muscle and produces bilateral muscle hyperalgesia. Furthermore, we explored sex differences in the mRNA and protein expression of the α2δ-1 subunit of voltage-gated calcium channels in the dorsal horn of the spinal cord and dorsal root ganglia after development of CWP. Results: Pregabalin fully attenuated muscle hyperalgesia bilaterally in male but not female mice with equal motor deficits produced in both sexes. In addition, using the conditioned place preference test, mice of both sexes with CWP spent significantly more time in the pregabalin-paired chamber compared with baseline, but not sig
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain” by Plumb et al. https://t.co/oiRGjcsUQ2 https://t.co/8shsM2JZ3b
-
-
Mashup Score: 1
vestigate potential sex differences in the analgesic efficacy of pregabalin that may contribute to disparities in human outcomes. Methods: We used a mouse model of chronic widespread muscle pain (CWP) to test the effects of pregabalin on muscle hyperalgesia, nonreflexive pain, and motor behaviors. The CWP pain model combines 2 pH 4.0 saline injections, spaced 5 days apart, into the gastrocnemius muscle and produces bilateral muscle hyperalgesia. Furthermore, we explored sex differences in the mRNA and protein expression of the α2δ-1 subunit of voltage-gated calcium channels in the dorsal horn of the spinal cord and dorsal root ganglia after development of CWP. Results: Pregabalin fully attenuated muscle hyperalgesia bilaterally in male but not female mice with equal motor deficits produced in both sexes. In addition, using the conditioned place preference test, mice of both sexes with CWP spent significantly more time in the pregabalin-paired chamber compared with baseline, but not sig
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain” by Plumb et al. https://t.co/oiRGjcsUQ2 https://t.co/8shsM2JZ3b
-
-
Mashup Score: 1
vestigate potential sex differences in the analgesic efficacy of pregabalin that may contribute to disparities in human outcomes. Methods: We used a mouse model of chronic widespread muscle pain (CWP) to test the effects of pregabalin on muscle hyperalgesia, nonreflexive pain, and motor behaviors. The CWP pain model combines 2 pH 4.0 saline injections, spaced 5 days apart, into the gastrocnemius muscle and produces bilateral muscle hyperalgesia. Furthermore, we explored sex differences in the mRNA and protein expression of the α2δ-1 subunit of voltage-gated calcium channels in the dorsal horn of the spinal cord and dorsal root ganglia after development of CWP. Results: Pregabalin fully attenuated muscle hyperalgesia bilaterally in male but not female mice with equal motor deficits produced in both sexes. In addition, using the conditioned place preference test, mice of both sexes with CWP spent significantly more time in the pregabalin-paired chamber compared with baseline, but not sig
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain” by Plumb et al. https://t.co/oiRGjcsUQ2 https://t.co/8shsM2JZ3b
-
-
Mashup Score: 3
ibitory neurotransmitter that can inhibit NP. The present study aimed to examine the role of spinal HDAC and its isoforms in neuropathy. Methods: Male Wistar Rat with chronic constriction injury (CCI)-induced peripheral neuropathy and HDAC inhibitor, panobinostat, was administrated intrathecally. We performed quantitative real-time polymerase chain reaction (RT-qPCR), western blot, and immunohistochemical analysis of lumbar spinal cord dorsal horn and nociceptive behaviors (thermal hyperalgesia and mechanical allodynia) measurements. Results: Herein, RT-qPCR analysis revealed that spinal hdac3, hdac4, and hdac6 were upregulated in CCI rats. Western blotting and immunofluorescence staining further confirmed that HDAC3, HDAC4, and HDAC6 were significantly upregulated, whereas GABA and its synthesis key enzyme glutamic acid decarboxylase (GAD) 65 were dramatically downregulated. Intrathecal panobinostat attenuated nociceptive behavior and restored the downregulated spinal GAD65 and GABA e
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury–induced neuropathy in rats” by Wen et al. https://t.co/A1oXjDiQeV https://t.co/z5Vqa7LQhD
-
-
Mashup Score: 3
ibitory neurotransmitter that can inhibit NP. The present study aimed to examine the role of spinal HDAC and its isoforms in neuropathy. Methods: Male Wistar Rat with chronic constriction injury (CCI)-induced peripheral neuropathy and HDAC inhibitor, panobinostat, was administrated intrathecally. We performed quantitative real-time polymerase chain reaction (RT-qPCR), western blot, and immunohistochemical analysis of lumbar spinal cord dorsal horn and nociceptive behaviors (thermal hyperalgesia and mechanical allodynia) measurements. Results: Herein, RT-qPCR analysis revealed that spinal hdac3, hdac4, and hdac6 were upregulated in CCI rats. Western blotting and immunofluorescence staining further confirmed that HDAC3, HDAC4, and HDAC6 were significantly upregulated, whereas GABA and its synthesis key enzyme glutamic acid decarboxylase (GAD) 65 were dramatically downregulated. Intrathecal panobinostat attenuated nociceptive behavior and restored the downregulated spinal GAD65 and GABA e
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury–induced neuropathy in rats” by Wen et al. https://t.co/A1oXjDiQeV https://t.co/z5Vqa7LQhD
-
Now in #PainReports: “Why might fears and worries persist after a pain education–grounded multimodal intervention for chronic back pain? A qualitative study” by @rodrizzo_pain et al. https://t.co/eveKWdWYeO https://t.co/FRQPSrpJ2K