-
Mashup Score: 1
known about the mechanisms underlying progression to multiple (more than 1) COPCs. This study aims to address the gap by investigating the role of common and modifiable risk factors, specifically sleep and circadian rhythm disturbances, in the development of multiple COPCs. Methods: The study will enroll 300 participants with cLBP, including 200 with cLBP only and 100 with cLBP plus other COPCs (ie, fibromyalgia, temporomandibular disorders, irritable bowel syndrome, and chronic headaches) and follow them up for 12 months. Sleep and circadian rhythms will be assessed using wireless sleep electroencephalography, 24-hour evaluation of the rhythm of urinary 6-sulfatoxymelatonin, actigraphy, and sleep diaries. Pain amplification using quantitative sensory testing, psychological distress using validated self-report measures, and the number of pain sites using a pain body map will also be assessed. Perspectives: This research aims to (1) comprehensively characterize sleep/circadian disturban
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 1
known about the mechanisms underlying progression to multiple (more than 1) COPCs. This study aims to address the gap by investigating the role of common and modifiable risk factors, specifically sleep and circadian rhythm disturbances, in the development of multiple COPCs. Methods: The study will enroll 300 participants with cLBP, including 200 with cLBP only and 100 with cLBP plus other COPCs (ie, fibromyalgia, temporomandibular disorders, irritable bowel syndrome, and chronic headaches) and follow them up for 12 months. Sleep and circadian rhythms will be assessed using wireless sleep electroencephalography, 24-hour evaluation of the rhythm of urinary 6-sulfatoxymelatonin, actigraphy, and sleep diaries. Pain amplification using quantitative sensory testing, psychological distress using validated self-report measures, and the number of pain sites using a pain body map will also be assessed. Perspectives: This research aims to (1) comprehensively characterize sleep/circadian disturban
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Sleep and circadian rhythm disturbances as risk and progression factors for multiple chronic overlapping pain conditions: a protocol for a longitudinal study” by @Dr_Moon90 et al. https://t.co/XNQfa9NsjU https://t.co/XLSYyxLOAW
-
-
Mashup Score: 1
known about the mechanisms underlying progression to multiple (more than 1) COPCs. This study aims to address the gap by investigating the role of common and modifiable risk factors, specifically sleep and circadian rhythm disturbances, in the development of multiple COPCs. Methods: The study will enroll 300 participants with cLBP, including 200 with cLBP only and 100 with cLBP plus other COPCs (ie, fibromyalgia, temporomandibular disorders, irritable bowel syndrome, and chronic headaches) and follow them up for 12 months. Sleep and circadian rhythms will be assessed using wireless sleep electroencephalography, 24-hour evaluation of the rhythm of urinary 6-sulfatoxymelatonin, actigraphy, and sleep diaries. Pain amplification using quantitative sensory testing, psychological distress using validated self-report measures, and the number of pain sites using a pain body map will also be assessed. Perspectives: This research aims to (1) comprehensively characterize sleep/circadian disturban
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Sleep and circadian rhythm disturbances as risk and progression factors for multiple chronic overlapping pain conditions: a protocol for a longitudinal study” by @Dr_Moon90 et al. https://t.co/XNQfa9NsjU https://t.co/XLSYyxLOAW
-
-
Mashup Score: 2
indication, this protocol enables the efficient evaluation of potential therapeutics with different mechanisms of action in 3 pain types: nociceptive pain (osteoarthritis), neuropathic pain (diabetic peripheral neuropathic pain), and mixed pain (chronic low back pain). Methods: The study design was determined before the identification of any specific molecule. Statistical simulations were conducted to optimize the methodology and design, the culmination of which were submitted to and accepted by the Complex Innovative Trial Design Pilot Meeting Program, a unique collaboration with the United States Food and Drug Administration. Benefits of the CPMP include limiting the number of study participants exposed to placebo and reducing the total sample size over time by leveraging placebo data across studies within a pain type and efficacy data across pain types for a specific molecule. The CPMP design enables: (1) efficient evaluation of multiple novel mechanisms of action; (2) the study of
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types” by Knopp et al. https://t.co/HJo3UIorev https://t.co/E3K3ieYKrc
-
-
Mashup Score: 2
indication, this protocol enables the efficient evaluation of potential therapeutics with different mechanisms of action in 3 pain types: nociceptive pain (osteoarthritis), neuropathic pain (diabetic peripheral neuropathic pain), and mixed pain (chronic low back pain). Methods: The study design was determined before the identification of any specific molecule. Statistical simulations were conducted to optimize the methodology and design, the culmination of which were submitted to and accepted by the Complex Innovative Trial Design Pilot Meeting Program, a unique collaboration with the United States Food and Drug Administration. Benefits of the CPMP include limiting the number of study participants exposed to placebo and reducing the total sample size over time by leveraging placebo data across studies within a pain type and efficacy data across pain types for a specific molecule. The CPMP design enables: (1) efficient evaluation of multiple novel mechanisms of action; (2) the study of
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types” by Knopp et al. https://t.co/HJo3UIorev https://t.co/E3K3ieYKrc
-
-
Mashup Score: 2
indication, this protocol enables the efficient evaluation of potential therapeutics with different mechanisms of action in 3 pain types: nociceptive pain (osteoarthritis), neuropathic pain (diabetic peripheral neuropathic pain), and mixed pain (chronic low back pain). Methods: The study design was determined before the identification of any specific molecule. Statistical simulations were conducted to optimize the methodology and design, the culmination of which were submitted to and accepted by the Complex Innovative Trial Design Pilot Meeting Program, a unique collaboration with the United States Food and Drug Administration. Benefits of the CPMP include limiting the number of study participants exposed to placebo and reducing the total sample size over time by leveraging placebo data across studies within a pain type and efficacy data across pain types for a specific molecule. The CPMP design enables: (1) efficient evaluation of multiple novel mechanisms of action; (2) the study of
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types” by Knopp et al. https://t.co/HJo3UIorev https://t.co/E3K3ieYKrc
-
-
Mashup Score: 4Bone metabolism in complex regional pain syndrome : PAIN Reports - 10 day(s) ago
nclear. Objectives: This study aimed to evaluate bone metabolism in CRPS using TPBS and bone serum markers. Methods: A deep learning model for automated segmentation quantified tracer enhancement in TPBS images. Serum markers analysed included alkaline phosphatase (AP), 25-OH vitamin D, osteoprotegerin, procollagen type I N-terminal propeptide (PINP), and β-C-terminal telopeptide, compared to 48 healthy controls (HC). The study included 114 patients with CRPS, 41 of whom underwent TPBS. Results: Of the 41 patients with CRPS with TPBS, 39 (95.1%) displayed radiotracer enhancement in the bone phase across CRPS subtypes. Serum markers of 114 patients did not significantly differ between patients and HC, nor did they correlate with TPBS enhancement, except in warm CRPS. In these patients, TPBS accumulation in the metacarpophalangeal region correlated with PINP (Spearman ρ = 0.63, P = 0.038), and AP levels were elevated at 78 U/L (interquartile range 64–88) compared to cold CRPS at 66 U/L (
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Bone metabolism in complex regional pain syndrome” by @HeikeRittner et al. https://t.co/Xlc3sM8puW https://t.co/XuimCrrux0
-
-
Mashup Score: 4Bone metabolism in complex regional pain syndrome : PAIN Reports - 10 day(s) ago
nclear. Objectives: This study aimed to evaluate bone metabolism in CRPS using TPBS and bone serum markers. Methods: A deep learning model for automated segmentation quantified tracer enhancement in TPBS images. Serum markers analysed included alkaline phosphatase (AP), 25-OH vitamin D, osteoprotegerin, procollagen type I N-terminal propeptide (PINP), and β-C-terminal telopeptide, compared to 48 healthy controls (HC). The study included 114 patients with CRPS, 41 of whom underwent TPBS. Results: Of the 41 patients with CRPS with TPBS, 39 (95.1%) displayed radiotracer enhancement in the bone phase across CRPS subtypes. Serum markers of 114 patients did not significantly differ between patients and HC, nor did they correlate with TPBS enhancement, except in warm CRPS. In these patients, TPBS accumulation in the metacarpophalangeal region correlated with PINP (Spearman ρ = 0.63, P = 0.038), and AP levels were elevated at 78 U/L (interquartile range 64–88) compared to cold CRPS at 66 U/L (
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Bone metabolism in complex regional pain syndrome” by @HeikeRittner et al. https://t.co/Xlc3sM8puW https://t.co/XuimCrrux0
-
-
Mashup Score: 4Bone metabolism in complex regional pain syndrome : PAIN Reports - 10 day(s) ago
nclear. Objectives: This study aimed to evaluate bone metabolism in CRPS using TPBS and bone serum markers. Methods: A deep learning model for automated segmentation quantified tracer enhancement in TPBS images. Serum markers analysed included alkaline phosphatase (AP), 25-OH vitamin D, osteoprotegerin, procollagen type I N-terminal propeptide (PINP), and β-C-terminal telopeptide, compared to 48 healthy controls (HC). The study included 114 patients with CRPS, 41 of whom underwent TPBS. Results: Of the 41 patients with CRPS with TPBS, 39 (95.1%) displayed radiotracer enhancement in the bone phase across CRPS subtypes. Serum markers of 114 patients did not significantly differ between patients and HC, nor did they correlate with TPBS enhancement, except in warm CRPS. In these patients, TPBS accumulation in the metacarpophalangeal region correlated with PINP (Spearman ρ = 0.63, P = 0.038), and AP levels were elevated at 78 U/L (interquartile range 64–88) compared to cold CRPS at 66 U/L (
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Bone metabolism in complex regional pain syndrome” by @HeikeRittner et al. https://t.co/Xlc3sM8puW https://t.co/XuimCrrux0
-
-
Mashup Score: 0
CRPS after surgery in Germany and treatments used by patients with CRPS, using claims data from the BARMER, a German nationwide health care insurance. Methods: A total of N = 85,862 BARMER patients with inpatient surgery on the upper or lower limb in 2018 were included. Patients with CRPS were identified by documented International Statistical Classification of Diseases and Related Health Problems-10 diagnosis within 12 months after surgery. For the same period, medication and nonpharmaceutical therapies for inpatient and outpatient care were assessed. Results: The overall incidence of CRPS within 12 months after surgery was 0.34%. With 0.60%, the incidence of CRPS after surgeries of the upper limb was 3 times higher than after lower-limb surgeries (0.20%). Women were more frequently affected, and most patients were between 50 and 70 years old. About 80% to 90% of patients with CRPS received physiotherapy and nonopioid pain medication within 12 months after surgery. Approximately 40% t
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Incidence and treatment of complex regional pain syndrome after surgery: analysis of claims data from Germany” by Teichmüller et al. https://t.co/OGz5iYA45j https://t.co/ZuK7R6dL2L
-
Now in #PainReports: “Sleep and circadian rhythm disturbances as risk and progression factors for multiple chronic overlapping pain conditions: a protocol for a longitudinal study” by @Dr_Moon90 et al. https://t.co/XNQfa9NsjU https://t.co/XLSYyxLOAW