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Mashup Score: 6
Accurate selection of patients with low-risk prostate cancer for active surveillance relies upon conventional clinical staging and grading criteria. New approaches in imaging as well as novel serum-, urine- and tissue-based biomarkers have been developed to reduce initial misclassification and predict risk of disease progression.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet
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Mashup Score: 3Urinary biomarkers to mitigate diagnostic delay in bladder cancer during the COVID-19 era - 3 year(s) ago
The COVID-19 pandemic has resulted in a substantial increase in waiting times for cystoscopies, prompting concerns of delayed diagnoses and substandard surveillance of bladder cancer. Expanding the role of urinary biomarkers in diagnostic and surveillance pathways could be a strategy to address this problem, and several novel biomarkers have shown promise for this purpose.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU In this Comment, @Kenrickng1 et al. discuss using urinary biomarkers for #BladderCancer diagnosis to address delays to cystoscopies as a result of the #COVID19 pandemic -> https://t.co/CVyZ1GfH3o @drandy2003 @Jkurol @prokarurol @nikhilvasdevuro https://t.co/c6pYRSkClG
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Mashup Score: 1Genomic and phenotypic heterogeneity in prostate cancer - 3 year(s) ago
This Review summarizes the manifestations of inter-tumoural and intra-tumoural heterogeneity in primary and metastatic prostate cancer, emphasizing the contribution of genomics studies and discussing the importance of phenotypic changes. The authors also critically discuss the implications for clinical management and research.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU Review by Haffner et al. summarizing the genomic and phenotypic heterogeneity of primary and metastatic #ProstateCancer, providing a framework for assessing heterogeneity and discussing the implications for clinical management and research -> https://t.co/q6YB74Roz4 https://t.co/zkKI5Q8fWf
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Mashup Score: 0
Multiparametric MRI enables early detection of progression and reclassification in patients with low-risk prostate cancer on active surveillance and offers the potential to reduce unnecessary biopsies. However, the reliability and reproducibility of MRI-directed surveillance during follow-up is unclear. A recent study highlights the potential and current shortcomings of this approach.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU In this News&Views, Ploussard and Renard-Penna consider the use of MRI in active surveillance for #ProstateCancer, discussing the potential advantages of this technology and the advances needed for its incoporation into daily practice -> https://t.co/LvXqWqdqNE https://t.co/UBqJwtxgDm
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Mashup Score: 0Is a targeted biopsy-only approach for prostate cancer diagnosis ready for the prime time? - 3 year(s) ago
The PRECISION trial demonstrated the ability of using multiparametric MRI to improve the diagnosis of clinically significant prostate cancer whilst reducing over-diagnosis of clinically insignificant cancer compared with systematic biopsy. Concerns remained about patients who were not biopsied owing to negative scans. A new study applies the PRECISION strategy to a contemporary cohort to answer…
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU In this News&Views, Sussman & Sidana discuss a recent study that used mpMRI to diagnose #ProstateCancer in a contemporary cohort in order to address concerns arising from the PRECISION trial -> https://t.co/QZBwskCHVT https://t.co/9q2BynxEV9
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Mashup Score: 0
Exposure to urology is essential for medical undergraduates to prepare them with the competencies required to manage basic urological conditions and to generate interest in the specialty. However, despite the existence of national curricula, the lack of urological exposure and falling competition ratios indicate a need for an evaluation of urological teaching in medical schools.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU Comment from Ng et al. on teaching of #Urology in UK medical schools, discussing a lack of exposure to urology among medical students and the need for evaluating urological teaching -> https://t.co/Ej561MHL9D https://t.co/nTp3JJ0w3N
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Mashup Score: 2Plastic exposure and urological malignancies — an emerging field - 4 year(s) ago
Plastics have an integral role in our daily lives but at a considerable cost to the environment and, as we are now learning, to human health. Increased plastic exposure has been linked to compromised endocrine function, reproductive health and semen quality and, potentially, urological cancers. However, the long-term consequences of plastic exposure remain to be seen.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU In this Comment, Patel et al. discuss plastic exposure and urological health, focussing on urological malignancies including #ProstateCancer, #BladderCancer and #KidneyCancer -> https://t.co/REC57rLHUv https://t.co/AAOkiIvfsE
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Mashup Score: 5Current evidence on screening for renal cancer - 4 year(s) ago
Renal cell carcinoma (RCC) incidence is increasing worldwide. Here, the authors consider the potential benefits and harms of screening for RCC and discuss whether enough evidence is available to begin a clinical trial of RCC screening.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU In this Perspectives, @JulietU_S et al. discuss potential harms and benefits of screening for #KidneyCancer, and whether sufficient evidence exists to conduct a clinical trial of kidney cancer screening -> https://t.co/pf5szaeWNi @srossi725 @grantissimus @CRUKCamUrol https://t.co/Q6Yc7QS2kM
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Mashup Score: 3
Complicated UTI (cUTI) incidence and the prevalence of antibiotic resistance among uropathogens are increasing. Here, the authors discuss different cUTI classification systems, describe current understanding of the aetiology of cUTIs and outline clinical studies of novel antibiotics in patients with cUTIs or pyelonephritis and the use of UTI as a model for other infection types in clinical…
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU Review by Wagenlehner et al. on complicated UTI (cUTI), describing the classification of clinical #UroUTI entities and the pathogenesis of cUTIs, and discussing novel antibiotics and clinical trials in patients with cUTI or pylonephritis -> https://t.co/4MZqDG5ztN https://t.co/kmHxWqBhMR
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Mashup Score: 0
Personalized decision-making is the ultimate goal of managing men with lower urinary tract symptoms caused by benign prostatic obstruction. Urodynamics can provide valuable information in these patients and a recent multicentre randomized trial has highlighted important findings warranting consideration, as well as indicating that further insights are needed.
Source: Nature Reviews UrologyCategories: Latest Headlines, UrologyTweet-
#NEWinNRU In this News & Views, @sachmalde and @EskinderSolomo1 discuss the use of #urodynamics in personalized decision making for treating patients with lower urinary tract symptoms, considering a recent multicentre randomized trial -> https://t.co/Mv2qK7HjaT https://t.co/TgGezRwxJl
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#NEWinNRU In this Review @JamesLLiuMD @HitenDPatel @alan_partin and colleagues discuss advances in the selection of patients with #ProstateCancer for active surveillance https://t.co/mdVRZg1kuC https://t.co/xjQWLeeVu7