A 35-year-old woman presented with a progressive 3-year history of personality changes and gait impairment. Neurologic examination revealed bilateral optic atrophy, spastic paraparesis, and impaired vibratory sensation in all limbs, and neuropsychological …

Language plays an important role in ensuring gender inclusivity within neurology. Despite progress in language inclusivity, such as the emergence of explicit pronouns, more remains to be done. Historically, sex and gender have been used interchangeably, …

The Editors are soliciting pre-submissions for four small breakout sessions that will take place in the second hour of the course. Each group will discuss three submissions amongst themselves. The submissions may include stories, essays, or poems that reflect the writer’s personal experience, offering insights into themselves, their patients, and human relationships. It is about who our patients are and who we are. Words like love, fear, anguish, and hope are not part of our scientific vocabulary, but

A 12-year-old girl with partial wheelchair dependence presented with progressive proximal weakness since age 5 and a history of juvenile systemic lupus erythematosus. Initial evaluation showed elevated creatine kinase (613 IU/L; reference < 250 IU/L) and proximal weakness, raising suspicion for myopathy, although muscle biopsy was normal. Neurologic examination revealed proximal and distal weakness with fasciculations and intermittent, low-amplitude, nonrhythmic hand movements, especially with posturing

A 7-year-old boy presented with bilateral mydriasis. General examination was notable for prune belly. Neurologic examination showed loss of peripheral vision in the left eye. Brain MRI (Figure, A and B) revealed chronic white matter injury of bilateral posterior cerebral hemispheres raising concern for vasculopathy and a V-shaped corpus callosum. Brain MRA (Figure, C and D) showed irregular appearance of middle cerebral artery branches and distal anterior and posterior cerebral arteries. Given unusual

On his sixth day of a Hawaiian cruise, a previously healthy 39-year-old man developed flu-like symptoms progressing over 10 days to include eye redness, rash, headache, and confusion. He returned to California on day 11 from illness onset and presented to a community-based emergency department where physical examination showed lethargy, mild disorientation, conjunctival erythema, and a nonblanching maculopapular rash involving his chest and dorsal hands. IV hydration and analgesia led to mild improvement,

A 42-year-old man presented with insidious-onset headache and diplopia of 6 months’ duration with left abducens palsy. MRI showed an extensive destructive central skull base mass involving the posterior clivus and floor of the sphenoid sinus and nasopharynx, extending into both cavernous sinuses (Figure 1, A–D). The laboratory workup (including ANCA, HIV, and serum IgG4) was unremarkable. CSF protein was elevated at 0.48 mg/dL. He underwent 2 nasopharyngeal biopsies, both of which were consistent with

A 59-year-old man presented with muscle cramps, stiffness in the bilateral legs, and hyperhidrosis for 2 months. Examination showed continuous muscle twitching involving the bilateral calves and deltoids with electromyogram (EMG) revealing spontaneous motor unit activity with myokymia (triplets and multiplets) in the gastrocnemius and deltoid. Immunofluorescence assay detected antibodies against contactin-associated protein-like 2 (CASPR2) suggestive of Isaacs syndrome. He received intravenous immunoglobul