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Mashup Score: 2Topotecan–Berzosertib Combination for Small Cell Lung Cancer - 3 year(s) ago
Combining the chemotherapy drug topotecan and the investigational drug berzosertib shrank tumors in some patients with small cell lung cancer (SCLC), the most aggressive form of lung cancer, according to results from an NCI-supported phase 1 clinical trial. Two phase 2 trials of the combination for SCLC are planned.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 7AMBRA1 Protein Found to Be an Important Tumor Suppressor - 3 year(s) ago
Researchers have shown that the loss of a protein called AMBRA1 can cause tumors to form in mice and is linked with worse outcomes in some human tumors. A lack of AMBRA1 may make some tumors resistant to CDK4/6 inhibitor drugs. The new research may lead to strategies for re-sensitizing cancer cells to these drugs.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 5Immunotherapy Improves Survival in Advanced Esophageal Cancer - 3 year(s) ago
In people with advanced esophageal cancer, combining nivolumab (Opdivo) with either chemotherapy or ipilimumab (Yervoy) improved how long they lived, according to results from a large clinical trial. Results from the trial, CheckMate 648, should change current clinical practice, experts said.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Immunotherapy Improves Survival in Advanced Esophageal Cancer - 3 year(s) ago
In people with advanced esophageal cancer, combining nivolumab (Opdivo) with either chemotherapy or ipilimumab (Yervoy) improved how long they lived, according to results from a large clinical trial. Results from the trial, CheckMate 648, should change current clinical practice, experts said.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4Avasopasem May Make Radiation Therapy More Effective - 3 year(s) ago
A drug called avasopasem manganese (AVA), which has been found to protect normal tissues from radiation therapy, can also make cancer cells more vulnerable to radiation treatment, a new study in mice suggests. AVA is already being tested in early clinical trials against several cancers, including pancreatic cancer.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Nivolumab and Relatlimab for Advanced Melanoma - 3 year(s) ago
People with advanced melanoma treated with two immunotherapy drugs—nivolumab (Opdivo) and a new drug called relatlimab, which targets a protein called LAG-3—lived longer without their cancer getting worse than those treated only with nivolumab, according to results from a large clinical trial.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 12Immunotherapy Improves Survival in Advanced Esophageal Cancer - 3 year(s) ago
In people with advanced esophageal cancer, combining nivolumab (Opdivo) with either chemotherapy or ipilimumab (Yervoy) improved how long they lived, according to results from a large clinical trial. Results from the trial, CheckMate 648, should change current clinical practice, experts said.
Source: National Cancer InstituteCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 6Immunotherapy Improves Survival in Advanced Esophageal Cancer - 3 year(s) ago
In people with advanced esophageal cancer, combining nivolumab (Opdivo) with either chemotherapy or ipilimumab (Yervoy) improved how long they lived, according to results from a large clinical trial. Results from the trial, CheckMate 648, should change current clinical practice, experts said.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Nivolumab-based combinations improve survival in advanced esophageal cancer: https://t.co/JYRE4A5xOt #NCICancerCurrentsblog #repost https://t.co/kCW3yPOzjZ
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Mashup Score: 3Whole-Genome Sequencing Could Help Guide AML, MDS Treatment - 3 year(s) ago
For people with acute myeloid leukemia and myelodysplastic syndromes, a new study suggests whole-genome sequencing could simplify and improve how doctors select the best treatment regimen for each patient. Whole-genome sequencing can determine the complete genetic makeup of a patient sample in a single test.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3PDX Mouse Models Match Genetics of Human Tumors - 3 year(s) ago
PDX mouse models of cancer largely retain the genetics of the human tumors from which they were initially created, results from an international study show. The findings provided strong reassurance that PDX are providing reliable results in research studies.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
A combination of two drugs can shrink the tumors of some patients with small cell lung cancer (#SCLC), the most aggressive form of lung cancer: https://t.co/lI79ZkKBIF #NCICancerCurrentsblog #repost https://t.co/XT06zRXAl5