• Mashup Score: 8

    Longitudinal levels of pre-diuretic spot urinary sodium (UNa+) showed a decreasing trajectory over time in ambulatory outpatients with stable, chronic heart failure (HF), and lower levels of UNa+ were associated with increased risks in all-cause mortality and long-term, HF-related hospitalizations, according to a brief report published in JACC: Heart Failure. In the ob servational, single-center prospective study conducted in Spain, Miguel Lorenzo, MD, et al., assessed 5,126 UNa+ determinations (collected

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    • Longitudinal levels of pre-diuretic spot UNa+ showed a ↘️ trajectory over time in ambulatory outpatients w/ stable, chronic HF, & lower levels of UNa+ were associated w/ ↗️ risks in all-cause mortality & long-term, HF-related hospitalizations. 🔗 https://t.co/uFX7pQALn4 #JACCHF https://t.co/eWMl1vWQQC

  • Mashup Score: 14

    The addition of aficamten to disopyramide was effective and well-tolerated in patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) with persistent left ventricular overflow tract (LVOT) obstruction, and the withdrawal of disopyramide did not reduce the effectiveness of aficamten, according to research published May 7 in JACC: Heart Failure. Ahmad Masri, MD, FACC, et al., drew from three trials of patients with oHCM: the open-label REDWOOD-HCM Cohort 3, the placebo-controlled SEQUOIA-HCM

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    • The addition of aficamten to disopyramide was effective & well-tolerated in patients w/ symptomatic obstructive HCM w/ persistent LVOT obstruction, & the withdrawal of disopyramide did not reduce the effectiveness of aficamten. Learn more: https://t.co/Jq2wkfTQ4e #JACCHF https://t.co/kdSFDWrGWP

  • Mashup Score: 11

    Donation after circulatory determination of death (DCD) heart transplant recipients with hearts retrieved via thoraco-abdominal normothermic regional perfusion (taNRP) were less likely to have severe primary graft dysfunction (PGD) and exhibited fewer episodes of biopsy-proven acute-cellular rejection (ACR) at one year compared to those with hearts retrieved through direct procurement and perfusion (DPP), according to an international, multicenter study presented at ISHLT 2025 and simultaneously published

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    • In an international study of DCD-HT, recipients of hearts retrieved by taNRP technique had lower rates of severe PGD & fewer episodes of biopsy-proven ACR in the first year when compared with those retrieved utilizing DPP. Read more: https://t.co/3hnXCwKwc2 #JACCHF @JACCJournals