“HS is the worst disease in dermatology.” As dermatologists specializing in hidradenitis suppurativa (HS) care, we have heard this sentiment many times from both patients and clinicians. We have witnessed HS derailing a patient’s life trajectory since adolescence and robbing individuals of their self-esteem, ability to function, and career and family planning dreams. On the clinician’s side, we understand the frustration of feeling uncertain about the best next steps in treatment when options are limited, and our best efforts are not doing enough to ease a patient’s suffering.